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CAD Generated MRI Series Improves Detection of Clinically Significant Prostate Cancer

By MedImaging International staff writers
Posted on 14 Oct 2022

Prostate cancer is the second most common cause of cancer death in men, after lung cancer. More...

Because of the aging population, its incidence is expected to approximately double by 2030. Though prostate cancer is one of the leading causes of cancer death in men, most men diagnosed with prostate cancer do not die from it. This disparity exists because smaller cancers are unlikely to progress far enough during the patients’ lifetimes to prove fatal. These cancers are considered clinically insignificant. However, clinically significant cancers are associated with a high probability of death within 10 years after diagnosis. Whether a cancer is considered clinically significant or insignificant is based on its Gleason score, the sum of a primary and a secondary grade assigned to the cancer by a pathologist.

Studies have shown men with clinically insignificant prostate cancers do not benefit from treatment. Still, many of these men end up receiving treatment as many clinicians, not wanting to miss any cancers, will err on the side of caution. This overtreatment has grown even more acute with increasing use of prostate-specific antigen (PSA) screening. Tests for the biomarker PSA are widely used for screening and diagnosis of prostate cancer, but there is still considerable debate about the extent to which these tests should inform decisions about performing biopsies in men with elevated levels of PSA, or even be used at all. As a result, more men undergo biopsy, leading to anxiety and possible detrimental effects of further interventions. Other patients are placed in active surveillance programs after detection of clinically insignificant cancers with regular assessments over time, which involve risks for the patients and additional costs for the health care system. Clinicians now face the challenge of figuring out how to detach the likelihood of overtreatment from the higher rates of diagnosis that accompany PSA screening.

Now, a new study by researchers at Massachusetts General Hospital (Boston, MA, USA) has found that the addition of a computer-aided diagnostic (CAD) generated MRI series improves detection of clinically significant prostate cancer. In the study, nine radiologists retrospectively interpreted 150 prostate MRI examinations without and then with an additional random forest-based CAD model-generated MRI series. Characteristics of biopsy negative versus positive (Gleason ≥ 7 adenocarcinoma) groups were compared using the Wilcoxon test for continuous and Pearson's chi-squared test for categorical variables. The diagnostic performance of readers was compared without versus with CAD using MRMC methods to estimate the area under the receiver operator characteristic curve (AUC). Inter-reader agreement was assessed using weighted inter-rater agreement statistics. Analyses were repeated in peripheral and transition zone subgroups.

The study revealed that among 150 men with median age 67 ± 7.4 years, those with clinically significant prostate cancer were older (68 ± 7.6 years vs. 66 ± 7.0 years; p < .02), had smaller prostate volume (43.9 mL vs. 60.6 mL; p < .001), and no difference in prostate specific antigen (PSA) levels (7.8 ng/mL vs. 6.9 ng/mL; p = .08), but higher PSA density (0.17 ng/mL/cc vs. 0.10 ng/mL/cc; p < .001). Inter-rater agreement (IRA) for PI-RADS scores was moderate without CAD and significantly improved to substantial with CAD (IRA = 0.47 vs. 0.65; p < .001). CAD also significantly improved average reader AUC (AUC = 0.72, vs. AUC = 0.67; p = .02). Based on these findings, the researchers concluded that the addition of a random forest method-based, CAD-generated MRI image series improved inter-reader agreement and diagnostic performance for the detection of clinically significant prostate cancer, particularly in the transition zone.

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57 (512.83836364746): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294794974 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

58 (!!!!! 1281.0230255127): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

59 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

60 (123.02398681641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

61 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

62 (160.93254089355): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

63 (721.93145751953): SELECT fid FROM jos_deeppockets WHERE id=294794974 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294794974 AND published='1' LIMIT 1

64 (101.08947753906): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

65 (91.075897216797): select jos_twitters.link from jos_twitters where cat=10

66 (54.121017456055): select jos_facebook.link from jos_facebook where cat=10

67 (46.968460083008): select jos_google_plus.link from jos_google_plus where cat=10

68 (44.107437133789): select jos_linkedin.link from jos_linkedin where cat=10

69 (57.93571472168): SELECT fid FROM jos_deeppockets WHERE id=294794974 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294794974 AND published='1' LIMIT 1

70 (57.93571472168): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

71 (524.99771118164): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294794974 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (512.83836364746): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294794974 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (73.909759521484): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

74 (72.956085205078): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (47.206878662109): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (49.114227294922): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294794974 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (31.948089599609): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294794974 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (35.04753112793): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

91 (60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

106 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

107 (55.074691772461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294794974 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (46.968460083008): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294794974 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

110 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

111 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294794974 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (584.12551879883): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294794974 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (718.11676025391): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (498.05641174316): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (168.0850982666): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

116 (65.803527832031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

117 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

118 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

119 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

120 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

121 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

122 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

123 (282.04917907715): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

124 (!!!!! 62732.934951782): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

125 (589.84756469727): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294794974 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294794974 AND type='deeppockets_item' AND published='1' LIMIT 1

126 (!!!!! 17349.9584198): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (149.01161193848): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (129.93812561035): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (55.789947509766): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (77.009201049805): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (44.107437133789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (502.10952758789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (56.028366088867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (53.167343139648): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (523.09036254883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (592.94700622559): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (52.928924560547): SELECT name FROM jos_deeppockets WHERE id=212

139 (41.961669921875): SELECT name FROM jos_deeppockets WHERE id=212

140 (691.17546081543): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (553.84635925293): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

143 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

144 (!!!!! 12669.086456299): TRUNCATE TABLE jos_trademed_module

145 (98.228454589844): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294794974 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (56.028366088867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294794974 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (914.8120880127): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

150 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

151 (!!!!! 1415.9679412842): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

152 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

153 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

154 (38.14697265625): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294794974 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294794974 AND type='deeppockets_item' AND published='1' LIMIT 1

155 (34.093856811523): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

157 (33.140182495117): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

158 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

159 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794974 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794974 AND published='1' LIMIT 1

160 (72.956085205078): select jos_twitters.link from jos_twitters where cat=10

161 (32.186508178711): select jos_facebook.link from jos_facebook where cat=10

162 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

163 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

164 (293.97010803223): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

165 (!!!!! 1019.0010070801): insert into jos_banners_delta values (14615,'2025-08-04 04:20:33','216.73.216.210','view'),(14202,'2025-08-04 04:20:33','216.73.216.210','view'),(14203,'2025-08-04 04:20:33','216.73.216.210','view')

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