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AI Software Aids Anatomical Segmentation Analysis of Brain Structures in MRI Images

By MedImaging International staff writers
Posted on 16 Aug 2022

Image: ClearPoint Maestro Brain Model has received FDA clearance (Photo courtesy of ClearPoint Neuro)

A new anatomical segmentation analysis tool is capable of automatic labeling, visualization, volumetric and shape quantification of segmentable brain structures from a set of MRI images. The software is intended to automate the process of identifying, labeling, and quantifying the volume and shape of brain structures visible in MRI images.

The first-generation anatomical segment analysis tool developed by ClearPoint Neuro, Inc. (Solana Beach, CA, USA) in partnership with Royal Philips (Amsterdam‎, Noord-Holland) emerged over 10 years ago from research aimed at detecting subtle volumetric and shape abnormalities in patients with mild traumatic brain injury. The ClearPoint Maestro Brain Model uses a unique methodology that combines deformable surfaces with active shape models and machine learning. More importantly, it provides point-based correspondence longitudinally and across patients. Cross-validation on more than 1,000 scans demonstrate highly reproducible results with sub-millimeter accuracy and normative values from 560 healthy subjects provide reference ranges for patient-specific assessments. The ClearPoint Maestro Brain Model has received 510(k) clearance.

“This is a tremendous milestone for ClearPoint and our collaboration with Philips as we are thrilled to introduce this new commercial tool into our portfolio,” commented Joe Burnett, President and CEO at ClearPoint Neuro. “This is a crucial first step in our path to make the Maestro Brain Model the ‘engine’ in our navigation system supporting multiple new applications in the future. Now that the standalone patient analysis tool is cleared, our development team will work to embed this software directly into the ClearPoint Navigation platform and add new functionality based on the priorities of the business.”

“The current version will enable reproducible analysis of patient data which will provide immediate value for our current and future biologics and drug delivery partners as they study volumetric infusion characteristics and longitudinal patient comparisons as part of their safety and pivotal trials,” commented Lyubomir Zagorchev, Vice President of Clinical Science and Applications at ClearPoint Neuro. “However, the goal of our future applications once embedded into the ClearPoint Navigation software will enable more advanced patient-specific target identification and trajectory planning across all ClearPoint applications. Our plan is to quantify drug delivery using intraoperative imaging and simulate patient-specific infusions in targeted brain regions. The unique shape representation in Maestro will provide reproducible lead placement for deep brain stimulation and micro electrode recording. Surface meshes of segmented anatomical regions will define safety zones and optimal trajectories for patient-specific laser ablations. This is really just the beginning of what is possible and we are excited to execute the limited market release of this product through the end of 2022.”

Related Links:
ClearPoint Neuro, Inc.
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65 (33.140182495117): select jos_facebook.link from jos_facebook where cat=10

66 (!!!!! 1438.1408691406): select jos_google_plus.link from jos_google_plus where cat=10

67 (102.99682617188): select jos_linkedin.link from jos_linkedin where cat=10

68 (102.99682617188): SELECT fid FROM jos_deeppockets WHERE id=294794272 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294794272 AND published='1' LIMIT 1

69 (396.0132598877): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (692.12913513184): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294794272 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (460.86311340332): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294794272 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 3827.8102874756): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (64.849853515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (42.200088500977): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (59.127807617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (60.081481933594): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294794272 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (29.087066650391): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294794272 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (31.948089599609): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (265.83671569824): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (73.909759521484): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (191.92695617676): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (89.168548583984): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (66.995620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (81.062316894531): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (59.843063354492): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (58.174133300781): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (631.09397888184): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

105 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

106 (72.002410888672): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294794272 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294794272 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (728.84559631348): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

109 (138.99803161621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

110 (130.17654418945): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294794272 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (504.97055053711): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294794272 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 4005.1937103271): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 2264.9765014648): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 2093.0767059326): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

115 (104.90417480469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

116 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

117 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

118 (137.0906829834): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

119 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

120 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

121 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

122 (483.98971557617): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294794272 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294794272 AND type='deeppockets_item' AND published='1' LIMIT 1

123 (!!!!! 1241187.8108978): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

124 (!!!!! 1467345.9529877): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

125 (!!!!! 7702.112197876): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

126 (!!!!! 8021.1162567139): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

127 (!!!!! 7950.0675201416): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

128 (!!!!! 8907.0796966553): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

129 (!!!!! 10235.786437988): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

130 (!!!!! 8348.9418029785): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

131 (431.77604675293): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

132 (415.08674621582): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

133 (198.8410949707): SELECT name FROM jos_deeppockets WHERE id=212

134 (50.067901611328): SELECT name FROM jos_deeppockets WHERE id=212

135 (689.98336791992): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

136 (464.20097351074): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

137 (!!!!! 1331.090927124): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

138 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

139 (!!!!! 3671.8845367432): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (110.86463928223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

142 (!!!!! 2480.0300598145): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

143 (!!!!! 1992.94090271): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

144 (173.80714416504): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

145 (100.13580322266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

146 (!!!!! 5455.9707641602): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294794272 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294794272 AND type='deeppockets_item' AND published='1' LIMIT 1

147 (82.969665527344): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

148 (43.869018554688): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

149 (38.14697265625): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

150 (!!!!! 3223.180770874): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

151 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794272 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794272 AND published='1' LIMIT 1

152 (69.141387939453): select jos_twitters.link from jos_twitters where cat=10

153 (50.067901611328): select jos_facebook.link from jos_facebook where cat=10

154 (39.815902709961): select jos_google_plus.link from jos_google_plus where cat=10

155 (36.954879760742): select jos_linkedin.link from jos_linkedin where cat=10

156 (!!!!! 25438.070297241): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

157 (!!!!! 6422.9965209961): insert into jos_banners_delta values (14615,'2025-06-17 07:04:18','216.73.216.120','view'),(14202,'2025-06-17 07:04:18','216.73.216.120','view'),(14203,'2025-06-17 07:04:18','216.73.216.120','view')

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