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Advanced MRI Marks Breakthrough for Patients with Heart Stiffening Disease

By MedImaging International staff writers
Posted on 31 Jul 2022
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Image: Stiff heart syndrome occurs when plaques of protein called amyloid build up in heart muscle (Photo courtesy of University College London)
Image: Stiff heart syndrome occurs when plaques of protein called amyloid build up in heart muscle (Photo courtesy of University College London)

Light-chain cardiac amyloidosis (stiff heart syndrome) is a life-limiting condition that occurs when plaques of protein called amyloid build up in heart muscle, affecting its ability to pump blood, and without treatment can rapidly lead to heart failure and death. However, assessing the condition has been difficult, as while clinicians can detect the presence of amyloid in the heart, there has been no safe test to measure the amount. This has also meant there has been no way of measuring the therapeutic effect of chemotherapy – the normal first line treatment. A patient’s response is currently assessed with indirect biological markers, but these do not measure the amount (or reduction) of cardiac amyloid – the drug’s ultimate target – and doctors find the markers less useful when trying to assess second-line chemotherapy treatments. Now, an advanced form of cardiac MRI has for the first-time enabled clinicians to measure the effectiveness of chemotherapy in patients with ‘stiff heart syndrome’.

Researchers at University College London (London, UK) have, for 10 years, been developing and refining Cardiovascular Magnetic Resonance (CMR) Extracellular Volume Mapping (ECV) for amyloid. This non-invasive technique enables clinicians to measure both the presence and amount of amyloid protein using MRI. Now for the first time they have used the technology to evaluate the success of chemotherapy treatment, by assessing cardiac amyloid regression or progression.

For the study 176 patients with light-chain cardiac amyloidosis had Cardiovascular Magnetic Resonance with Extracellular Volume Mapping. CMR scans with ECV mapping were done at diagnosis, and then at six, 12 and 24 months after starting chemotherapy. The advanced MRI technique allowed researchers to accurately measure the amount of amyloid protein in hearts, and, for the first-time ever, to measure the changes in response to chemotherapy on repeat scans. By measuring the changes they could detect which patients would have a better or worse prognosis. Further, combining the results with blood tests for the disease, it was found almost 40% of patients had a substantial improvement (reduction) in amyloid deposition, something that was not thought to be possible before – showing how effective chemotherapy can be. The researchers believe that the MRI technique should now be used immediately to diagnose and assess all cases of light-chain cardiac amyloidosis.

“Since MRI scans are widely available, by developing the use of ECV mapping in a machine that already is used for these patients, we hope that its use can be made available to more patients to help improve their care,” said Professor Marianna Fontana (UCL Division of Medicine), senior author and a British Heart Foundation (BHF) Clinical Fellow. “The aim would be to use these scans routinely for all patients with the disease to help doctors monitor the response to chemotherapy to help improve patient survival, which is very poor in patients who do not respond to treatment.”

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94 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (23.841857910156): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
105 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
106 (49.829483032227): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294794076 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294794076 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (!!!!! 1232.8624725342): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
109 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
110 (48.87580871582): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294794076 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (370.97930908203): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294794076 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (557.89947509766): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (341.89224243164): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
115 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
116 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
117 (79.870223999023): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
118 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
119 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
120 (279.90341186523): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
121 (!!!!! 89226.961135864): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
122 (!!!!! 1036.8824005127): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
123 (!!!!! 4096.0311889648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
124 (348.09112548828): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294794076 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294794076 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (!!!!! 766849.99465942): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (77.962875366211): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (280.85708618164): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1
128 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1
129 (169.99244689941): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1
130 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1
131 (104.90417480469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1
132 (82.969665527344): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1
133 (391.00646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
134 (300.16899108887): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
135 (144.95849609375): SELECT name FROM jos_deeppockets WHERE id=212
136 (31.948089599609): SELECT name FROM jos_deeppockets WHERE id=212
137 (427.0076751709): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
138 (343.08433532715): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
139 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
140 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
141 (!!!!! 8248.8059997559): TRUNCATE TABLE jos_trademed_module
142 (95.129013061523): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294794076 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
143 (62.942504882812): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294794076 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
144 (791.07284545898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
145 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
146 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
147 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
148 (!!!!! 1037.1208190918): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
149 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
150 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
151 (38.862228393555): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294794076 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294794076 AND type='deeppockets_item' AND published='1' LIMIT 1
152 (35.04753112793): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)
153 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)
154 (33.855438232422): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
155 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
156 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294794076 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294794076 AND published='1' LIMIT 1
157 (102.99682617188): select jos_twitters.link from jos_twitters where cat=10
158 (27.179718017578): select jos_facebook.link from jos_facebook where cat=10
159 (28.133392333984): select jos_google_plus.link from jos_google_plus where cat=10
160 (26.941299438477): select jos_linkedin.link from jos_linkedin where cat=10
161 (267.02880859375): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)
162 (!!!!! 1176.8341064453): insert into jos_banners_delta values (14615,'2025-04-30 21:44:57','18.216.130.198','view'),(14202,'2025-04-30 21:44:57','18.216.130.198','view'),(14203,'2025-04-30 21:44:57','18.216.130.198','view')