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MRI May Halve Breast-Cancer Mortality Among Women Carrying Variants in Three Genes

By MedImaging International staff writers
Posted on 04 Mar 2022

Image: Screening MRI detects small cancer in patient`s breast (Photo courtesy of University of Washington School of Medicine)

Annual MRI screenings starting at ages 30 to 35 may reduce breast-cancer mortality by more than 50% among women who carry certain genetic changes in three genes, according to a new comparative modeling analysis.

The predictions by researchers at the University of Washington School of Medicine (Seattle, WA, USA) involve pathogenic variants in ATM, CHEK2 and PALB2 genes – which collectively are as prevalent as the much-reported BRCA1/2 gene mutations. The researchers contend that their findings support MRI screening in some women earlier than existing guidelines propose. To realize a benefit of cancer screening guidelines based on genetic susceptibility, a woman would need to know she carries an implicated gene variant before receiving a disease diagnosis. More often it’s the case that a genetic test panel is administered after someone tests positive for cancer – too late to be of preventive value for the patient but potentially life-saving for blood relatives who could seek genetic testing.

Using established breast-cancer simulation models, the researchers input age-specific risk estimates involving more than 32,000 breast-cancer patients and a similar number of patients who had no cancer. The simulations compared the combined performance of mammography and MRI against mammography alone, and projected that annual MRI conferred significant additional benefit to these populations. The simulations in this study also predicted the volume of false-positive screening results and benign biopsies, per 1,000 women scanned, that would accompany the researchers’ recommendations for annual MRIs starting earlier. Those projections translate to about four false-positive screening results and one to two benign biopsies per woman over a 40-year screening span, according to the researchers. The team hopes their analysis will aid all organizations that issue guidance for medical oncologists and radiologists.

“Screening guidelines have been difficult to develop for these women because there haven’t been clinical trials to inform when to start and how to screen,” said Dr. Kathryn Lowry, an assistant professor of radiology at the University of Washington School of Medicine. “For women with pathogenic variants in these genes, our modeling analysis predicted a lifetime risk of developing breast cancer at 21% to 40%, depending on the variant. We project that starting annual MRI screening at age 30 to 35, with annual mammography starting at age 40, will reduce cancer mortality for these populations of women by more than 50%.”

“We also found that starting mammograms earlier than age 40 did not have a meaningful benefit but increased false-positive screens,” Lowry added.

Related Links:
University of Washington School of Medicine

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69 (49.114227294922): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (277.04238891602): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791853 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (324.01084899902): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791853 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (38.862228393555): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (66.041946411133): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (41.007995605469): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791853 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791853 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (33.140182495117): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (66.995620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

105 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

106 (70.810317993164): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791853 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (62.942504882812): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791853 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

109 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

110 (54.836273193359): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791853 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 1179.9335479736): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791853 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (564.0983581543): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (324.01084899902): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

115 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

116 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

117 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

118 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

119 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

120 (301.12266540527): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 18430.948257446): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (187.15858459473): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

123 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

124 (398.15902709961): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791853 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791853 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 1115789.1750336): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 813647.98545837): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (360.01205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (210.04676818848): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (174.99923706055): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (471.11511230469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (329.01763916016): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (205.03997802734): SELECT name FROM jos_deeppockets WHERE id=212

136 (32.901763916016): SELECT name FROM jos_deeppockets WHERE id=212

137 (414.13307189941): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (352.85949707031): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (!!!!! 1008.0337524414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

140 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

141 (!!!!! 9444.9520111084): TRUNCATE TABLE jos_trademed_module

142 (869.0357208252): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791853 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (499.01008605957): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791853 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (311.85150146484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

147 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

148 (!!!!! 1008.9874267578): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

150 (40.769577026367): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

151 (416.04042053223): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791853 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791853 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (56.028366088867): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

153 (28.133392333984): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

154 (30.040740966797): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

156 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791853 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791853 AND published='1' LIMIT 1

157 (67.949295043945): select jos_twitters.link from jos_twitters where cat=10

158 (28.133392333984): select jos_facebook.link from jos_facebook where cat=10

159 (28.133392333984): select jos_google_plus.link from jos_google_plus where cat=10

160 (26.941299438477): select jos_linkedin.link from jos_linkedin where cat=10

161 (272.98927307129): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (976.0856628418): insert into jos_banners_delta values (14615,'2025-05-01 05:58:27','18.188.148.202','view'),(14202,'2025-05-01 05:58:27','18.188.148.202','view'),(14203,'2025-05-01 05:58:27','18.188.148.202','view')

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