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New Machine Learning Model Flags Abnormal Brain Scans in Real-Time

By MedImaging International staff writers
Posted on 22 Feb 2022

Image: Deep learning framework reduces reporting times for abnormal head MRI scans (Photo courtesy of King`s College London)

A new machine learning model can reduce reporting times for abnormal examinations by accurately flagging abnormalities at the time of imaging.

Researchers at King's College London (London, UK) have developed a deep learning framework based on convolutional neural networks to flag clinically relevant abnormalities at the time of imaging, in minimally processed, routine, hospital-grade axial T2-weighted head MRI scans. The work was motivated by delays in reporting of scans in hospitals. A growing national and international demand for MRI scans, alongside a shortage of radiologists, together have led to an increase in the time taken to report head MRI scans in recent years. Delays cause the knock-on effect that it takes longer for the correct treatment to be given to patients, and therefore poorer patient outcomes and inflated healthcare costs.

In a simulation study, the researchers found that their model reduced the wait times for reports for patients with abnormalities by about two weeks from 28 days to 14 days and from 9 days to 5 days. The current achievements are underpinned by a recent model which addresses one existing problem blocking overarching developments in the application of deep learning to imaging: the difficulty in obtaining large, clinically representative, accurately-labeled datasets. Whilst accessing large hospital datasets is achievable, the data are usually unlabelled. The deep learning framework based on convolutional neural networks used in the current study to flag clinically relevant abnormalities at the time of imaging, could not have been developed without this earlier work which allowed head MRI dataset labeling at scale.

In the current study, another step forwards towards clinical translation is that the researchers use routine, hospital-grade axial T2-weighted head MRI scans which have undergone little processing before triage analysis. This means head MRI scans can be used in the form that they arrive from the scanner which both cuts down from minutes to seconds the time that would otherwise be spent processing the images, but also allows more abnormalities to be detected in other areas captured by the head MRI – such as diseases in the skull, and around the eyes and nose. The speed and coverage of the abnormality detection system enables real-time applications.

“Our model can reduce reporting times for abnormal examinations by accurately flagging abnormalities at the time of imaging, thereby allowing radiology departments to priorities limited resources into reporting these scans first. This would expedite intervention by the referring clinical team,” said Dr. David Wood, Research Associate, School of Biomedical Engineering & Imaging Sciences.

“Having previously built and validated a labeled head MRI dataset using cutting edge machine learning methodology through a team of data scientists and hospital radiologists, the same team have now built and validated a new machine learning model that can triage head MRI scans so the abnormal scans can be at the front of the queue for reporting. The potential benefit to patients and healthcare systems is enormous,” added Dr. Thomas Booth, Senior Lecturer in Neuroimaging at the School of Biomedical Engineering & Imaging Sciences and Consultant Diagnostic and Interventional Neuroradiologist at King’s College Hospital.

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68 (101.08947753906): SELECT fid FROM jos_deeppockets WHERE id=294791703 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294791703 AND published='1' LIMIT 1

69 (500.91743469238): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (200.98686218262): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791703 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (197.8874206543): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791703 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (132.08389282227): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (69.141387939453): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (24.080276489258): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (41.007995605469): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791703 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (27.179718017578): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791703 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (30.040740966797): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (24.080276489258): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

105 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

106 (47.922134399414): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791703 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791703 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (120.16296386719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

109 (104.90417480469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

110 (163.07830810547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791703 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (440.12069702148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791703 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (550.98533630371): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (326.87187194824): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

115 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

116 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

117 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

118 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

119 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

120 (183.10546875): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 39394.855499268): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

123 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

124 (509.97734069824): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791703 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791703 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 481085.06202698): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 2414.2265319824): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 3629.9228668213): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (44.107437133789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (70.095062255859): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (504.97055053711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (442.9817199707): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (145.91217041016): SELECT name FROM jos_deeppockets WHERE id=212

136 (612.02049255371): SELECT name FROM jos_deeppockets WHERE id=212

137 (679.01611328125): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (684.97657775879): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (241.04118347168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

140 (197.8874206543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

141 (!!!!! 15496.969223022): TRUNCATE TABLE jos_trademed_module

142 (!!!!! 1120.0904846191): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791703 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (274.8966217041): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791703 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (406.98051452637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (431.06079101562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (580.0724029541): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

147 (118.01719665527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

148 (!!!!! 2135.9920501709): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (684.97657775879): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

150 (196.93374633789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

151 (187.15858459473): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791703 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791703 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (85.115432739258): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

153 (72.002410888672): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

154 (!!!!! 1470.8042144775): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (!!!!! 2871.036529541): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

156 (221.96769714355): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791703 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791703 AND published='1' LIMIT 1

157 (117.06352233887): select jos_twitters.link from jos_twitters where cat=10

158 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

159 (27.894973754883): select jos_google_plus.link from jos_google_plus where cat=10

160 (25.98762512207): select jos_linkedin.link from jos_linkedin where cat=10

161 (256.06155395508): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 2537.0121002197): insert into jos_banners_delta values (14615,'2025-05-01 08:18:27','18.188.0.144','view'),(14202,'2025-05-01 08:18:27','18.188.0.144','view'),(14203,'2025-05-01 08:18:27','18.188.0.144','view')

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