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Special MRI Protocol Could Help Treat Patients with Brain Hemorrhages

By MedImaging International staff writers
Posted on 14 Jan 2022

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Researchers are investigating how a special magnetic resonance imaging (MRI) protocol can help understand which patients might be at risk for hematoma expansion after intracerebral hemorrhage.

Researchers at The University of Texas Health Science Center at Houston (Houston, TX, USA) are conducting a study to determine how MRI can be used to help clinicians treat patients with brain hemorrhages. The trial is investigating a special MRI protocol to help understand which patients might be at risk for hematoma expansion and determining when patients might be safely placed back on anti-thrombotic medications such as aspirin.

Hematoma expansion is a pool of clotted blood that can occur after a blood vessel breaks. Intracerebral hemorrhage - a type of brain bleed that occurs anywhere within brain tissue - accounts for about 10% to 15% of all strokes and is associated with high mortality. It is most commonly the result of hypertension, which can cause the thin-walled arteries that bring blood to areas deep inside the brain to rupture, releasing blood into brain tissue. As blood spills into and puts pressure on the brain, it becomes deprived of oxygen and blood supply. Brain cells die, and the resulting inflammatory responses damage more cells in the area surrounding the hematoma.

There is a 30-40% mortality rate for intracerebral hemorrhage, according to the researchers, with 73% of patients experiencing some degree of hematoma growth, and with about one-third of them exhibiting hematoma expansion - a 33% growth of hematoma volume within 24 hours of intracerebral hemorrhage.

The current standard of care is a computed tomography (CT) scan, a non-invasive X-ray used to detect any bleeding. Both the CT and MRI scans are capable of locating and detecting hematoma expansion, but researchers believes a slight modification to existing MRI protocols can differentiate between clotted (or coagulated) versus non-clotted (or non-coagulated) blood within the hematoma.

“We are studying whether MRI can provide more complete information which could alter the clinical management of patients with hemorrhagic stroke,” said Muhammad Haque, PhD, assistant professor of neurology with McGovern Medical School at UTHealth Houston and the UTHealth Institute for Stroke and Cerebrovascular Disease. “The current practice of CT scans is inadequate for the full assessment of patients. We seek to assist providers with information that will help them plan early interventions and might even eliminate unnecessary surgical procedures. Our ultimate goal is to take this data and go for an extensive study of this imaging method.”

“With this MRI sequence, we hope to see within the hematoma what percentage of the blood is already clotted and what percentage is in the liquid form,” Haque added. “We will determine if patients with mostly clotted blood are less likely to see their blood expand.”

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68 (41.961669921875): SELECT fid FROM jos_deeppockets WHERE id=294791235 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294791235 AND published='1' LIMIT 1

69 (40.054321289062): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (422.95455932617): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791235 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (329.97131347656): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791235 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (54.121017456055): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (82.969665527344): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (66.041946411133): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791235 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (40.054321289062): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791235 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (45.7763671875): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (71.048736572266): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (101.80473327637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

105 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

106 (72.956085205078): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791235 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (67.949295043945): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791235 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (122.0703125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

109 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

110 (71.048736572266): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791235 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (705.00373840332): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294791235 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (782.96661376953): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (545.02487182617): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (164.98565673828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

115 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

116 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

117 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

118 (118.97087097168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

119 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

120 (370.02563476562): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 29975.891113281): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (173.09188842773): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

123 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

124 (682.83081054688): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791235 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791235 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 570979.11834717): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (88.930130004883): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (64.849853515625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (560.99891662598): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (445.12748718262): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (310.89782714844): SELECT name FROM jos_deeppockets WHERE id=212

136 (40.054321289062): SELECT name FROM jos_deeppockets WHERE id=212

137 (548.8395690918): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (544.78645324707): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

140 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

141 (!!!!! 17133.951187134): TRUNCATE TABLE jos_trademed_module

142 (189.78118896484): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791235 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (133.99124145508): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294791235 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (643.96858215332): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (152.8263092041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (153.0647277832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

147 (122.0703125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

148 (!!!!! 1480.1025390625): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (137.8059387207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

150 (197.17216491699): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

151 (164.98565673828): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294791235 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294791235 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (149.96528625488): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

153 (341.89224243164): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

154 (61.988830566406): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

156 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294791235 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294791235 AND published='1' LIMIT 1

157 (42.915344238281): select jos_twitters.link from jos_twitters where cat=10

158 (32.901763916016): select jos_facebook.link from jos_facebook where cat=10

159 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

160 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

161 (334.9781036377): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 2724.8859405518): insert into jos_banners_delta values (14615,'2025-05-01 08:36:56','3.149.238.207','view'),(14202,'2025-05-01 08:36:56','3.149.238.207','view'),(14203,'2025-05-01 08:36:56','3.149.238.207','view')

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