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Research Identifies Children at High Risk for MS

By MedImaging International staff writers
Posted on 24 Oct 2017

Image: The arrows in the images indicate abnormalities on the children’s MRI brain scans with no apparent symptoms of multiple sclerosis (Photo courtesy of Yale University).

Researchers in the US have found that MRI scans can help them identify children who have a high risk of developing Multiple Sclerosis (MS), even before symptoms become apparent.

The study included 38 children from 16 sites, in six countries, all of whom underwent Magnetic Resonance Imaging (MRI) scans for headache or other reasons. When MS is diagnosed in children, it may already be too late to prevent MS-related relapses and disabilities.

The study was carried out by researchers from the Yale School of Medicine (New Haven, CT, USA), and published in the November 2017, issue of the journal Neurology: Neuroimmunology & Neuroinflammation. The MRI brain scans showed unexpected signs of MS without the children showing any clinical symptoms of the disease. The results of the study could lead to earlier diagnosis and treatment for MS.

Around 42% of the children participating in the study who showed MRI findings of MS, developed the first clinical symptoms of MS around two years after the MRI. The children at the greatest risk of developing clinical systems of MS were those with a specific marker in spinal fluid, or those who showed changes to the spinal cord in the MRI images.

Lead author of the study, Naila Makhani, MD, assistant professor of pediatrics and neurology at Yale School of Medicine, said, "For the first time we have proposed a definition of RIS in children. Children with Radiologically Isolated Syndrome (RIS) may represent a high-risk group of children that needs to be followed more closely for the later development of clinical multiple sclerosis. We hope that our work will help inform expert guidelines for how to follow up children with RIS and help us accurately inform families of the risk of later developing multiple sclerosis, something we were previously unable to do."

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Yale School of Medicine

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71 (304.9373626709): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294771212 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (51.021575927734): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (26.226043701172): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (24.080276489258): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (39.100646972656): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294771212 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (27.894973754883): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294771212 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (31.948089599609): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

105 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

106 (53.167343139648): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294771212 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294771212 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

109 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

110 (47.922134399414): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294771212 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (382.1849822998): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294771212 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (560.04524230957): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (465.15464782715): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (109.91096496582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

115 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

116 (89.168548583984): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

117 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

118 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

119 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

120 (236.98806762695): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 25435.209274292): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (134.94491577148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

123 (84.161758422852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

124 (432.01446533203): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294771212 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294771212 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 883511.06643677): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 1455.0685882568): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (308.03680419922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (43.869018554688): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (163.79356384277): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (72.002410888672): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (128.98445129395): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (490.90385437012): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (343.08433532715): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (134.94491577148): SELECT name FROM jos_deeppockets WHERE id=212

136 (31.948089599609): SELECT name FROM jos_deeppockets WHERE id=212

137 (495.91064453125): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (376.93977355957): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

140 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

141 (!!!!! 8533.9546203613): TRUNCATE TABLE jos_trademed_module

142 (766.99256896973): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294771212 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (158.07151794434): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294771212 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (462.05520629883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (213.8614654541): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

147 (160.93254089355): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

148 (!!!!! 1338.005065918): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (173.80714416504): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

150 (114.91775512695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

151 (445.12748718262): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294771212 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294771212 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (182.8670501709): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

153 (471.83036804199): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

154 (35.04753112793): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (164.03198242188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

156 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294771212 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294771212 AND published='1' LIMIT 1

157 (165.93933105469): select jos_twitters.link from jos_twitters where cat=10

158 (82.969665527344): select jos_facebook.link from jos_facebook where cat=10

159 (28.133392333984): select jos_google_plus.link from jos_google_plus where cat=10

160 (27.179718017578): select jos_linkedin.link from jos_linkedin where cat=10

161 (405.07316589355): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 3314.9719238281): insert into jos_banners_delta values (14615,'2025-06-18 10:43:59','216.73.216.120','view'),(14202,'2025-06-18 10:43:59','216.73.216.120','view'),(14203,'2025-06-18 10:43:59','216.73.216.120','view')

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