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MRI Calculates Kidney Scarring without Biopsy

By MedImaging International staff writers
Posted on 15 Sep 2017

Image: In a new study, MRI elastography demonstrates heterogenous distribution of stiffness in the kidney (Photo courtesy of Anish Kirpalani).

Noninvasive magnetic resonance imaging (MRI) elastography can measure kidney damage and predict future kidney function within one year, according to a new study.

Researchers at St. Michael’s Hospital (Toronto, Canada) conducted a study in 16 patients (mean age 55 years) who underwent MRI elastography following a kidney transplant in order to determine if MRI-based elastography could measure organ stiffness to help estimate fibrosis in the allografts, and predict progression of allograft dysfunction. All participants first underwent free-breathing, flow-compensated elastography on a 3.0-T MRI scanner. They subsequently underwent serial estimated glomerular filtration rate (eGFR) measurement after the elastography scan for a follow-up period of up to one year.

The mean stiffness value of the kidney allograft was compared with both the histopathologic Banff fibrosis score and the rate of eGFR change during the follow-up period. The results revealed that whole-kidney mean stiffness ranged between 3.5 and 7.3 kPa, and correlated with the biopsy-derived Banff fibrosis score. The researchers also found negative correlations between whole-kidney stiffness and both baseline eGFR and eGFR change over time; but irrespective of baseline eGFR, increased kidney stiffness was associated with a greater eGFR decline. The study was published on August 30, 2017, in Clinical Journal of the American Society of Nephrology.

“The MRI allowed us to get a full picture of the kidney, whereas with a biopsy we would only see a tiny piece. We were able to tell that in some parts of the kidney it's very stiff, and in others, it's not stiff at all, which is information we couldn't get from a biopsy,” said lead author radiologist Anish Kirpalani, MD. “Scarring is a big problem for transplant patients, and with MRI we may be able to better guide how kidney transplant patients are treated early on to improve their long-term outcomes.”

“Clinicians are hesitant to send patients for a test that has risks such as internal bleeding, unless a diagnosis can't be made without it. With this new MRI test, doctors can gather valuable information in the many patients for whom the risks of a biopsy are too high,” concluded senior author nephrologist Darren Yuen, MD. “This new MRI test may help facilitate the testing of new anti-scarring treatments. By providing a needle-free way to measure kidney scarring, we may create more opportunities for this crucial research into finding an effective anti-scarring treatment.”

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69 (47.922134399414): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (465.15464782715): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294770781 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (407.93418884277): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294770781 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (66.041946411133): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (80.82389831543): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (64.13459777832): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294770781 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (40.054321289062): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294770781 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (45.061111450195): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (66.041946411133): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

105 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

106 (58.889389038086): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294770781 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (48.87580871582): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294770781 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

109 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

110 (65.088272094727): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294770781 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (586.98654174805): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294770781 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (509.02366638184): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (381.9465637207): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

115 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

116 (78.201293945312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

117 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

118 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

119 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

120 (243.18695068359): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 18857.002258301): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (118.01719665527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

123 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

124 (426.05400085449): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294770781 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294770781 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 600782.87124634): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (112.05673217773): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (61.988830566406): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (77.009201049805): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (61.03515625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (549.0779876709): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (443.93539428711): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (43.153762817383): SELECT name FROM jos_deeppockets WHERE id=212

136 (30.040740966797): SELECT name FROM jos_deeppockets WHERE id=212

137 (524.04403686523): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (389.09912109375): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

140 (49.829483032227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

141 (!!!!! 10282.039642334): TRUNCATE TABLE jos_trademed_module

142 (128.03077697754): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294770781 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (93.936920166016): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294770781 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (859.02214050293): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

147 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

148 (!!!!! 1360.1779937744): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

150 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

151 (57.93571472168): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294770781 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294770781 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (40.054321289062): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

153 (33.855438232422): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

154 (46.014785766602): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

156 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770781 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770781 AND published='1' LIMIT 1

157 (72.002410888672): select jos_twitters.link from jos_twitters where cat=10

158 (43.153762817383): select jos_facebook.link from jos_facebook where cat=10

159 (41.007995605469): select jos_google_plus.link from jos_google_plus where cat=10

160 (44.822692871094): select jos_linkedin.link from jos_linkedin where cat=10

161 (416.04042053223): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1654.8633575439): insert into jos_banners_delta values (14615,'2025-06-19 08:26:37','216.73.216.120','view'),(14202,'2025-06-19 08:26:37','216.73.216.120','view'),(14203,'2025-06-19 08:26:37','216.73.216.120','view')

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