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MRI Helps Probe the Psychopathic Brain

By MedImaging International staff writers
Posted on 20 Jul 2017
Image: Dr. Josh Buckholtz, PhD, and the Psychiatric Neuroimaging Division MRI scanner (Photo courtesy of MGH).
Image: Dr. Josh Buckholtz, PhD, and the Psychiatric Neuroimaging Division MRI scanner (Photo courtesy of MGH).
A new suggests that disrupted prefrontal regulation of the cortico-striatal circuit drives the dysfunctional decision-making common to psychopaths.

Researchers at Harvard University (Cambridge, MA, USA), Massachusetts General Hospital (MGH; Boston, USA), the University of Wisconsin (Madison, USA), and other institutions scanned the brains of 49 inmates in two medium-security prisons as they took part in a delayed gratification test, which asked them to choose between receiving a small amount of money immediately, or a larger amount at a later time. The results were then fit to a model that showed not only how impulsive each participant's behavior was, but also identified brain regions playing a role in assessing the relative value of each choice.

The results revealed that psychopathy was associated with stronger subjective value-related activity within the nucleus accumbens (NAcc) during inter-temporal choice, and with weaker intrinsic functional connectivity between NAcc and the ventromedial prefrontal cortex. The researchers suggest that this cortico-striatal circuit dysregulation drives erroneous decision-making in psychopathy (as indicated by more frequent criminal convictions), and could denote an important neurobiological risk factor. The study was published on July 5, 2017, in Neuron.

“We found that connections between the striatum and the ventral medial prefrontal cortex were much weaker in people with psychopathy,” said senior author associate professor Josh Buckholtz, PhD, of Harvard University and MGH. “The more psychopathic a person is, the greater the magnitude of that striatal response. That suggests that the way they are calculating the value rewards is dysregulated - they may over-represent the value of immediate reward.”

“They're not aliens, they're people who make bad decisions. The same kind of short-sighted, impulsive decision-making that we see in psychopathic individuals has also been noted in compulsive over-eaters and substance abusers,” concluded Dr. Buckholtz. “If we can put this back into the domain of rigorous scientific analysis, we can see psychopaths aren't inhuman, they're exactly what you would expect from humans who have this particular kind of brain wiring dysfunction.”

The striatum assigns values to different actions without much temporal context. It is the responsibility of the prefrontal cortex to make prospective judgments on how an action will affect the future. Increasing evidence suggests that the prefrontal cortex uses the outcome of this mental process to change how strongly the striatum responds to rewards. When this prefrontal modulating influence is weakened, the value of the more immediate choice may become dramatically over-represented.

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(57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
50
(109.19570922852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
51
(51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
52
(411.9873046875): SELECT name FROM jos_deeppockets WHERE id=294770087 LIMIT 1
53
(337.12387084961): SELECT name FROM jos_deeppockets_archive WHERE id=294770087 LIMIT 1
54
(57.93571472168): SELECT a.*
 FROM jos_components AS a
 WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' )
 AND a.option = 'com_syndicate'
55
(61.988830566406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294770087
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
56
(456.09474182129): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294770087
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
57
(!!!!! 1374.9599456787): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
58
(79.870223999023): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
59
(158.78677368164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
60
(65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
61
(144.00482177734): select cover from jos_number
where journalid in (5) and cover is not null
order by left(issue,2)+right(issue,2)*12 desc limit 1
62
(710.96420288086): SELECT fid FROM jos_deeppockets WHERE id=294770087 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294770087 AND published='1'  LIMIT 1
63
(77.009201049805): SELECT id,name,sponsor_text
                    FROM jos_deeppockets dp
					left outer join jos_channel_sponsor cs
					on dp.id=cs.fid
                    WHERE cat=10
                    AND TYPE='file_folder'
                    AND published=1
                    AND id=212
                    ORDER BY `ordering`
64
(72.956085205078): select jos_twitters.link from jos_twitters where cat=10
65
(46.014785766602): select jos_facebook.link from jos_facebook where cat=10
66
(46.014785766602): select jos_google_plus.link from jos_google_plus where cat=10
67
(46.014785766602): select jos_linkedin.link from jos_linkedin where cat=10
68
(66.041946411133): SELECT fid FROM jos_deeppockets WHERE id=294770087 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294770087 AND published='1'  LIMIT 1
69
(51.975250244141): SELECT id,name,sponsor_text
                    FROM jos_deeppockets dp
					left outer join jos_channel_sponsor cs
					on dp.id=cs.fid
                    WHERE cat=10
                    AND TYPE='file_folder'
                    AND published=1
                    AND id=212
                    ORDER BY `ordering`
70
(520.94459533691): SELECT fid FROM jos_deeppockets
								WHERE cat=10
								AND id=294770087
								AND (type='deeppockets_item' OR type='deeppockets_item_link') 
								AND published='1' 
								LIMIT 1
71
(630.85556030273): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294770087 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
72
(50.067901611328): SELECT id,name,title
 FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
			AND id != 294743300
			AND id != 294743301
			AND id != 294743302
			AND id != 294743303
			AND id != 294743304
			AND id != 294743305
			AND id != 294743306
			AND id != 294743307
			AND id != 294743308
			AND id != 294743309
			AND id != 294743310
			AND metakey != 'aacc'
		ORDER BY `ordering`
73
(85.115432739258): SELECT show_live FROM jos_com_show_setting LIMIT 1
74
(45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1
75
(89.168548583984): SELECT show_live FROM jos_com_show_setting LIMIT 1
76
(48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1
77
(32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1
78
(29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1
79
(30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1
80
(29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
81
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
82
(27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
83
(28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1
84
(28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1
85
(28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
86
(28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
87
(79.154968261719): SELECT fid FROM jos_deeppockets
								WHERE cat=10
								AND id=294770087
								AND (type='deeppockets_item' OR type='deeppockets_item_link') 
								AND published='1' 
								LIMIT 1
88
(32.901763916016): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294770087 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
89
(36.001205444336): SELECT id,name,title
 FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
			AND id != 294743300
			AND id != 294743301
			AND id != 294743302
			AND id != 294743303
			AND id != 294743304
			AND id != 294743305
			AND id != 294743306
			AND id != 294743307
			AND id != 294743308
			AND id != 294743309
			AND id != 294743310
			AND metakey != 'aacc'
		ORDER BY `ordering`
90
(67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1
91
(41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1
92
(46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1
93
(38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1
94
(53.167343139648): SELECT show_live FROM jos_com_show_setting LIMIT 1
95
(40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1
96
(!!!!! 2223.9685058594): SELECT show_live FROM jos_com_show_setting LIMIT 1
97
(93.936920166016): SELECT show_live FROM jos_com_show_setting LIMIT 1
98
(35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1
99
(29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1
100
(29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
101
(29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
102
(28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
103
(33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1
104
(143.05114746094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
105
(51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
106
(72.002410888672): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294770087
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
107
(67.949295043945): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294770087
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
108
(85.115432739258): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
109
(49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
110
(89.168548583984): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							
							AND dp.id=294770087
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
111
(474.92980957031): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								
								AND dp.id=294770087
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
112
(560.99891662598): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as ex
							ON ex.id = dp.author
							LEFT JOIN jos_deeppockets as dp2
							ON dp2.id = dp.fid
							WHERE dp.author != 0
							AND dp.cat = 10
							AND dp.published = 1
							AND (
								(dp.fid = 294743300)
								OR (dp.fid = 294743301)
								OR (dp.fid = 294743302)
								OR (dp.fid = 294743303)
								OR (dp.fid = 294743304)
								OR (dp.fid = 294743305)
								OR (dp.fid = 294743306)
								OR (dp.fid = 294743307)
								OR (dp.fid = 294743308)
								OR (dp.fid = 294743309)
								OR (dp.fid = 294743310)
								)
							ORDER BY RAND()
							LIMIT 1
113
(327.82554626465): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as ex
							ON ex.id = dp.author
							LEFT JOIN jos_deeppockets as dp2
							ON dp2.id = dp.fid
							WHERE dp.author != 0
							AND dp.cat = 10
							AND dp.published = 1
							AND (
								(dp.fid = 294743300)
								OR (dp.fid = 294743301)
								OR (dp.fid = 294743302)
								OR (dp.fid = 294743303)
								OR (dp.fid = 294743304)
								OR (dp.fid = 294743305)
								OR (dp.fid = 294743306)
								OR (dp.fid = 294743307)
								OR (dp.fid = 294743308)
								OR (dp.fid = 294743309)
								OR (dp.fid = 294743310)
								)
							ORDER BY RAND()
							LIMIT 1
114
(82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
115
(56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
116
(98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
117
(51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
118
(77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
119
(58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
120
(174.99923706055): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
121
(!!!!! 19034.147262573): SELECT
				*
			FROM
				jos_deeppockets
			WHERE
				jos_deeppockets.cat = 10
			AND
				jos_deeppockets.type = 'deeppockets_item'
			AND
				jos_deeppockets.published = 1
			AND
				jos_deeppockets.created + INTERVAL 14 DAY >= NOW()
			ORDER BY
				jos_deeppockets.hits DESC
			LIMIT
				7
122
(95.844268798828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
123
(46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
124
(356.91261291504): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294770087 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294770087 AND type='deeppockets_item' AND published='1'  LIMIT 1
125
(!!!!! 830705.88111877): (
				SELECT
					dp.id,
					dp.name,
					dp.title,
					dp.video,
					dp.video_source,
					dp.created

				FROM
					jos_deeppockets AS dp

				WHERE
					dp.video != ''
				AND
					dp.video_source != ''
				AND
					dp.cat = 10
				AND
					dp.published = 1
				AND
					dp.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			UNION
			(
				SELECT
					dpa.id,
					dpa.name,
					dpa.title,
					dpa.video,
					dpa.video_source,
					dpa.created

				FROM
					jos_deeppockets_archive AS dpa

				WHERE
					dpa.video != ''
				AND
					dpa.video_source != ''
				AND
					dpa.cat = 10
				AND
					dpa.published = 1
				AND
					dpa.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			ORDER BY
				created DESC

			LIMIT
				3
126
(!!!!! 821322.91793823): (
				SELECT
					dp.id,
					dp.name,
					dp.title,
					dp.video,
					dp.video_source,
					dp.created

				FROM
					jos_deeppockets AS dp

				WHERE
					dp.video != ''
				AND
					dp.video_source != ''
				AND
					dp.cat = 10
				AND
					dp.published = 1
				AND
					dp.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			UNION
			(
				SELECT
					dpa.id,
					dpa.name,
					dpa.title,
					dpa.video,
					dpa.video_source,
					dpa.created

				FROM
					jos_deeppockets_archive AS dpa

				WHERE
					dpa.video != ''
				AND
					dpa.video_source != ''
				AND
					dpa.cat = 10
				AND
					dpa.published = 1
				AND
					dpa.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			ORDER BY
				created DESC

			LIMIT
				3
127
(72.002410888672): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800513

			LIMIT 1
128
(30.994415283203): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800513

			LIMIT 1
129
(79.870223999023): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800359

			LIMIT 1
130
(40.054321289062): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800359

			LIMIT 1
131
(34.093856811523): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800361

			LIMIT 1
132
(28.133392333984): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294800361

			LIMIT 1
133
(634.90867614746): SELECT *
                            FROM jos_deeppockets
                            WHERE 1=1 
                              AND id=294770087
                              AND (type='deeppockets_item' OR type='deeppockets_item_link')
                              AND published='1'
                            LIMIT 1
134
(509.97734069824): SELECT *
                            FROM jos_deeppockets_archive
                            WHERE 1=1 
                              AND id=294770087
                              AND (type='deeppockets_item' OR type='deeppockets_item_link')
                              AND published='1'
                            LIMIT 1
135
(51.975250244141): SELECT name FROM jos_deeppockets WHERE id=212
136
(40.054321289062): SELECT name FROM jos_deeppockets WHERE id=212
137
(581.97975158691): SELECT *,
    DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
    DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
    FROM jos_events
    WHERE state=1
    AND publish_up > NOW()
    and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) 
    ORDER BY publish_up ASC LIMIT 3
138
(473.0224609375): SELECT *,
    DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
    DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
    FROM jos_events
    WHERE state=1
    AND publish_up > NOW()
    and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) 
    ORDER BY publish_up ASC LIMIT 3
139
(!!!!! 1240.9687042236): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
140
(87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
141
(!!!!! 8481.9793701172): TRUNCATE TABLE jos_trademed_module
142
(127.79235839844): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294770087
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1
143
(746.01173400879): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294770087
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1
144
(510.93101501465): SELECT *
   FROM jos_deeppockets
   WHERE 1=1 
   AND id=294770087
   AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
145
(69.856643676758): SELECT *
   FROM jos_deeppockets
   WHERE 1=1 
   AND id=294770087
   AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
146
(82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
147
(62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
148
(!!!!! 1110.0769042969): SELECT jos_item.*
						FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id
						WHERE 1=1
						AND (jos_item.imgMini<>'')
						AND jos_item.type='L'
						AND jos_item.numberID= (
									 SELECT jos_number.id
									 FROM jos_number
									 WHERE jos_number.journalID IN (10)
						
									and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P')
									 ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC
									 LIMIT 0,1
									 )
						ORDER BY RAND() DESC LIMIT 6
149
(61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
150
(46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
151
(408.88786315918): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294770087 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294770087 AND type='deeppockets_item' AND published='1'  LIMIT 1
152
(41.007995605469): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=212 or channel_id is null)
153
(29.087066650391): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=212 or channel_id is null)
154
(34.093856811523): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
155
(66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
156
(46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294770087 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294770087 AND published='1'
		LIMIT 1
157
(41.961669921875): select jos_twitters.link from jos_twitters where cat=10
158
(30.994415283203): select jos_facebook.link from jos_facebook where cat=10
159
(30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10
160
(31.948089599609): select jos_linkedin.link from jos_linkedin where cat=10
161
(257.01522827148): update jos_bannersmanager_banner
			set impmade=impmade+1
			where id in(14615,14202,14203)
162
(!!!!! 1332.9982757568): insert into jos_banners_delta values (14615,'2025-06-19 09:09:33','216.73.216.120','view'),(14202,'2025-06-19 09:09:33','216.73.216.120','view'),(14203,'2025-06-19 09:09:33','216.73.216.120','view')