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Brain Abnormalities Discovered in Bipolar Patients

By MedImaging International staff writers
Posted on 10 May 2017

Image: Research shows bipolar patients tend to have gray matter reductions in frontal brain regions involved in self-control (orange colors), while sensory and visual regions are normal (gray colors) (Photo courtesy of the ENIGMA Bipolar Consortium/Derrek Hibar et al.).

The results of a new global MRI study show thinning of gray matter in patients with bipolar disorder.

The researchers used the Magnetic Resonance Imaging (MRI) data from their study to build a roadmap of bipolar disorder, and the affects this condition has on the brain. The brain regions most affected by the disorder are used for inhibition, and emotions.

The research was part of the international consortium ENIGMA (Enhancing Neuro Imaging Genetics Through Meta Analysis), and was led by the University of Southern California Keck School of Medicine Stevens Neuroimaging and Informatics Institute. The research findings were published in the May 2, 2017, issue of the journal Molecular Psychiatry. For their study, the researchers used MRI scans of 2,447 adults suffering from bipolar disorder, as well as scans from 4,056 healthy control subjects.

The results of the study showed thinning of brain gray matter in patients with the disorder, compared to the healthy control subjects. The researchers found that the greatest deficits were in the frontal and temporal regions of the brain controlling inhibition and motivation.
According to the researchers, the clear and consistent changes in key brain regions provide insight into the underlying mechanisms of the disorder, and could enable future research into new medications and treatments.

Senior author of the study, Ole A. Andreassen, professor, Norwegian Centre for Mental Disorders Research, University of Oslo, said, "We created the first global map of bipolar disorder and how it affects the brain, resolving years of uncertainty on how people's brains differ when they have this severe illness."

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72 (!!!!! 2020.8358764648): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 3411.0546112061): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (94.175338745117): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (86.069107055664): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294769181 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (30.994415283203): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294769181 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (31.948089599609): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (269.17457580566): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (65.088272094727): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (77.009201049805): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (77.009201049805): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (42.200088500977): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (54.836273193359): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (77.962875366211): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (64.849853515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (53.167343139648): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (391.00646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

105 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

106 (132.08389282227): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294769181 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294769181 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (598.90747070312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

109 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

110 (143.76640319824): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294769181 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (595.0927734375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294769181 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (749.11117553711): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (458.95576477051): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (157.11784362793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

115 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

116 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

117 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

118 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

119 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

120 (315.90461730957): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 53828.001022339): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

123 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

124 (561.95259094238): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294769181 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294769181 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 686000.82397461): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (132.08389282227): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (75.101852416992): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (61.988830566406): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (33.140182495117): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (550.98533630371): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (389.09912109375): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (45.061111450195): SELECT name FROM jos_deeppockets WHERE id=212

136 (36.001205444336): SELECT name FROM jos_deeppockets WHERE id=212

137 (550.98533630371): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (416.04042053223): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

140 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

141 (!!!!! 9232.0442199707): TRUNCATE TABLE jos_trademed_module

142 (98.943710327148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294769181 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (72.002410888672): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294769181 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (!!!!! 1171.8273162842): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

147 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

148 (!!!!! 1127.0046234131): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

150 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

151 (38.14697265625): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294769181 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294769181 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (55.789947509766): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

153 (27.894973754883): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

154 (55.074691772461): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

156 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294769181 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294769181 AND published='1' LIMIT 1

157 (36.954879760742): select jos_twitters.link from jos_twitters where cat=10

158 (31.948089599609): select jos_facebook.link from jos_facebook where cat=10

159 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

160 (31.948089599609): select jos_linkedin.link from jos_linkedin where cat=10

161 (418.18618774414): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1869.2016601562): insert into jos_banners_delta values (14615,'2025-06-19 17:15:39','216.73.216.120','view'),(14202,'2025-06-19 17:15:39','216.73.216.120','view'),(14203,'2025-06-19 17:15:39','216.73.216.120','view')

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