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Researchers Use MRI and ASL Techniques to Diagnose Alzheimer’s

By MedImaging International staff writers
Posted on 06 Jul 2016

Image: An MRI scan showing shrinkage of the frontal and temporal lobes, indicative of dementia (Photo courtesy of SPL).

Researchers have found that they can use Arterial Spin Labeling (ASL) Magnetic Resonance Imaging (MRI) together with machine learning to detect early forms of dementia.

ASL-MRI perfusion maps show the distribution of blood in various regions of the brain, and can help clinicians detect Mild Cognitive Impairment (MCI) and other early forms of dementia. Functional changes in the brain caused by Alzheimer’s disease are already present before structural changes become evident in imaging scans.

The study that included 260 participants was published on July 6, 2016, in the online issue of the journal Radiology. The researchers taught an automated machine learning program to recognize patterns in the perfusion maps so that they could identify the levels of cognitive impairment of a patient. One hundred patients were diagnosed with probable Alzheimer’s disease, 60 were diagnosed with MCI, and 100 with Subjective Cognitive Decline (SCD). The study included 26 healthy control subjects.

Using the new technique the researchers were able to differentiate between patients with Alzheimer’s disease, and those with MCI and SCD. Using automated machine learning training the researchers could then predict the diagnosis of a single patient with an accuracy of between 82% and 90%.

Alle Meije Wink, PhD, principal investigator of the study from the VU Medical Center (VUmc; Amsterdam, Netherlands), said, “An MRI can help with the diagnosis of Alzheimer’s disease. However, the early diagnosis of Alzheimer’s disease is problematic. With standard diagnostic MRI, we can see advanced Alzheimer’s disease, such as atrophy of the hippocampus. But at that point, the brain tissue is gone and there’s no way to restore it. It would be helpful to detect and diagnose the disease before it’s too late. ASL is a promising alternative functional biomarker for the early diagnosis of Alzheimer’s disease. ASL MRI can identify brain changes that appear early in disease process, when there’s a window of opportunity for intervention. If the disease process from SCD to MCI to Alzheimer’s disease could be intercepted or slowed, this technique could play a role in screening.”

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64 (545.97854614258): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

65 (782.01293945312): select jos_twitters.link from jos_twitters where cat=10

66 (38.14697265625): select jos_facebook.link from jos_facebook where cat=10

67 (85.830688476562): select jos_google_plus.link from jos_google_plus where cat=10

68 (555.03845214844): select jos_linkedin.link from jos_linkedin where cat=10

69 (693.08280944824): SELECT fid FROM jos_deeppockets WHERE id=294764941 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294764941 AND published='1' LIMIT 1

70 (338.07754516602): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

71 (!!!!! 3053.1883239746): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294764941 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (454.90264892578): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294764941 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (612.02049255371): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

74 (309.94415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (356.91261291504): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (!!!!! 3735.0654602051): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (190.01960754395): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (366.9261932373): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (66.041946411133): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (118.97087097168): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (571.96617126465): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (66.041946411133): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (!!!!! 3832.8170776367): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294764941 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (113.01040649414): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294764941 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (55.074691772461): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

91 (!!!!! 8810.9970092773): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (!!!!! 7481.8134307861): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (82.969665527344): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (!!!!! 3545.9995269775): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (125.16975402832): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (!!!!! 1804.8286437988): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

106 (123.97766113281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

107 (!!!!! 4708.0516815186): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294764941 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (855.92269897461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294764941 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (!!!!! 20619.15397644): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

110 (118.01719665527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

111 (455.85632324219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294764941 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (532.86552429199): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294764941 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (!!!!! 7011.890411377): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 4675.1499176025): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (!!!!! 6905.0788879395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

116 (!!!!! 7992.9828643799): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

117 (!!!!! 7628.9176940918): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

118 (!!!!! 7966.0415649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

119 (!!!!! 7623.1956481934): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

120 (!!!!! 7966.9952392578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

121 (!!!!! 7629.8713684082): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

122 (!!!!! 7973.9093780518): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

123 (!!!!! 7904.7679901123): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

124 (!!!!! 139940.02342224): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

125 (!!!!! 4317.9988861084): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294764941 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294764941 AND type='deeppockets_item' AND published='1' LIMIT 1

126 (!!!!! 40409.088134766): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (773.90670776367): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (563.14468383789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (175.95291137695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (631.80923461914): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (!!!!! 6291.8663024902): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (82.015991210938): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (47.922134399414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (515.93780517578): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (66.041946411133): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (296.83113098145): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (281.09550476074): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (174.04556274414): SELECT name FROM jos_deeppockets WHERE id=212

139 (36.954879760742): SELECT name FROM jos_deeppockets WHERE id=212

140 (728.84559631348): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (550.0316619873): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (129.93812561035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

143 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

144 (!!!!! 16086.101531982): TRUNCATE TABLE jos_trademed_module

145 (191.92695617676): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294764941 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (81.062316894531): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294764941 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (969.17152404785): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (57.220458984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

150 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

151 (!!!!! 1237.8692626953): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

152 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

153 (!!!!! 3176.212310791): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

154 (92.029571533203): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294764941 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294764941 AND type='deeppockets_item' AND published='1' LIMIT 1

155 (37.908554077148): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (68.902969360352): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

157 (35.04753112793): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

158 (!!!!! 2959.9666595459): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

159 (!!!!! 4008.0547332764): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764941 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764941 AND published='1' LIMIT 1

160 (53.167343139648): select jos_twitters.link from jos_twitters where cat=10

161 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

162 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

163 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

164 (445.84274291992): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

165 (!!!!! 2848.8636016846): insert into jos_banners_delta values (14615,'2025-08-13 01:26:49','216.73.216.186','view'),(14202,'2025-08-13 01:26:49','216.73.216.186','view'),(14203,'2025-08-13 01:26:49','216.73.216.186','view')

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