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Novel Imaging Technique Could Predict Brain Bleeding Following a Stroke

By MedImaging International staff writers
Posted on 28 Jun 2016

Scientists in the US have used MRI brain scans of stroke patients to confirm the relationship between the extent that the Blood-Brain Barrier (BBB) has been disrupted, and the severity of bleeding, after invasive stroke therapy.

The researchers analyzed Magnetic Resonance Imaging (MRI) scans of more than one hundred stroke patients. More...

The scans were taken before clinicians treated the patients with endovascular therapy, within 12 hours of the onset of the stroke.

The study was carried out by scientists at the US National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS) and published online before print on June 17, 2016, in the journal Neurology.

The study authors concluded that the extent of disruption to the brain BBB, as revealed in MRI image scans, could help clinicians determine which patients would be unlikely to benefit from endovascular therapy.

Richard Leigh, M.D., scientist at NINDS, and one of the study authors, said, "The biggest impact of this research is that information from MRI scans routinely collected at a number of research hospitals and stroke centers can inform treating physicians on the risk of bleeding. It is too early to say how these images will be able to help guide clinical decisions, but they can expand how we think about stroke, especially as we try to broaden treatment options for this disease that can have devastating consequences."

Related Links:
National Institute of Neurological Disorders and Stroke

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64 (71.048736572266): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

65 (46.968460083008): select jos_twitters.link from jos_twitters where cat=10

66 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

67 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

68 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

69 (32.901763916016): SELECT fid FROM jos_deeppockets WHERE id=294764813 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294764813 AND published='1' LIMIT 1

70 (31.948089599609): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

71 (395.05958557129): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294764813 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (324.01084899902): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294764813 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (54.121017456055): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

74 (72.002410888672): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (58.889389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (56.028366088867): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (61.988830566406): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294764813 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (36.001205444336): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294764813 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (42.915344238281): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

91 (64.849853515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

106 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

107 (61.03515625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294764813 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (70.095062255859): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294764813 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

110 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

111 (65.803527832031): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294764813 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (581.02607727051): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294764813 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (547.88589477539): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (395.05958557129): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

116 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

117 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

118 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

119 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

120 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

121 (84.161758422852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

122 (37.193298339844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

123 (271.08192443848): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

124 (!!!!! 20043.849945068): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

125 (504.0168762207): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294764813 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294764813 AND type='deeppockets_item' AND published='1' LIMIT 1

126 (!!!!! 7426.9771575928): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (118.97087097168): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (56.982040405273): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (39.815902709961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (50.067901611328): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (389.09912109375): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (146.15058898926): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (49.114227294922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (548.12431335449): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (356.19735717773): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (50.067901611328): SELECT name FROM jos_deeppockets WHERE id=212

139 (38.862228393555): SELECT name FROM jos_deeppockets WHERE id=212

140 (586.03286743164): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (466.10832214355): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

143 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

144 (!!!!! 9796.8578338623): TRUNCATE TABLE jos_trademed_module

145 (136.13700866699): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294764813 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (84.877014160156): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294764813 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (935.79292297363): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

150 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

151 (!!!!! 1244.7834014893): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

152 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

153 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

154 (39.100646972656): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294764813 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294764813 AND type='deeppockets_item' AND published='1' LIMIT 1

155 (35.04753112793): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (33.855438232422): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

157 (34.093856811523): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

158 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

159 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764813 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764813 AND published='1' LIMIT 1

160 (46.968460083008): select jos_twitters.link from jos_twitters where cat=10

161 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

162 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

163 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

164 (369.07196044922): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

165 (!!!!! 4432.9166412354): insert into jos_banners_delta values (14615,'2025-08-13 01:26:54','216.73.216.186','view'),(14202,'2025-08-13 01:26:54','216.73.216.186','view'),(14203,'2025-08-13 01:26:54','216.73.216.186','view')

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