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Restriction Spectrum Imaging with MRI Used to Predict Prostate Cancer Tumor Grade

By MedImaging International staff writers
Posted on 22 Jun 2016

Image: The image on the left is a magnetic resonance image (MRI) of a prostate enhanced with restriction spectrum imaging (RSI). The higher-grade tumor is indicated by orange and yellow. The image on the right is a digitized section of the prostate with the tumors outlined with blue dotted lines (Photo courtesy of UC San Diego Health).

The results of a new study indicate that RSI biomarkers can be used to enhance the ability of MRI to detect prostate cancer tumors, and predict their grade and stage of development, and enable improved treatment options.

The new imaging tool could help clinicians distinguish between benign or low-grade tumors, and aggressive prostate cancer and guide treatment, and biopsy procedures.

The researchers from the University of California, San Diego School of Medicine (UCSD; San Diego, CA, USA) published the results of the study online in the June 1, 2016, issue of the journal Clinical Cancer Research. According to the researchers Restricted Spectrum Imaging – Magnetic Resonance Imaging (RSI-MRI) can correct for magnetic field distortions.

The researchers enlisted 10 patients for the study and evaluated more than 2,700 discrete data points. The researchers concluded that RSI-MRI could be used as a stand-alone, non-contrast screening tool in the future. An RSI-MRI scan would take only 15 minutes while a standard contrast-enhanced exam today takes between 40 minutes and an hour. Early diagnosis of prostate cancer is crucial to help improve the prognosis of a patient.

Senior author of the study David S. Karow, MD, PhD, assistant professor of radiology at the UCSD, said, “Noninvasive imaging is used to detect disease, but RSI-MRI takes it a step further. We can predict the grade of a tumor sometimes without a biopsy of the prostate tissue. This is taking all that’s good about multi-parametric MRI and making it better. The addition of RSI to a pelvic MRI added between 2.5 to 5 minutes to scanning time making it a fast and highly accurate tool with decreased risk compared to contrast MRI which involves injecting patients with dye.”

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71 (226.97448730469): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294764733 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (43.153762817383): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (24.795532226562): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (53.882598876953): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294764733 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (40.054321289062): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294764733 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (45.061111450195): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (316.14303588867): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (262.02201843262): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (113.96408081055): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (190.01960754395): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (121.11663818359): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (176.90658569336): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (514.98413085938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

105 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

106 (176.90658569336): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294764733 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (364.06517028809): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294764733 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (751.97219848633): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

109 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

110 (80.82389831543): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294764733 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (501.15585327148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294764733 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (735.99815368652): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (436.06758117676): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (104.90417480469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

115 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

116 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

117 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

118 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

119 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

120 (215.05355834961): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

121 (!!!!! 24169.921875): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

122 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

123 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

124 (319.00405883789): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294764733 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294764733 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 422249.07875061): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (92.983245849609): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (294.92378234863): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

128 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800513 LIMIT 1

129 (233.88862609863): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

130 (48.160552978516): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800359 LIMIT 1

131 (175.95291137695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

132 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294800361 LIMIT 1

133 (442.0280456543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (274.1813659668): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (143.76640319824): SELECT name FROM jos_deeppockets WHERE id=212

136 (34.093856811523): SELECT name FROM jos_deeppockets WHERE id=212

137 (428.91502380371): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (368.11828613281): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

140 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

141 (!!!!! 9483.814239502): TRUNCATE TABLE jos_trademed_module

142 (805.85479736328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294764733 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

143 (85.830688476562): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294764733 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

144 (980.85403442383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

145 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

146 (602.96058654785): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

147 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

148 (!!!!! 1527.0709991455): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

149 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

150 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

151 (46.968460083008): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294764733 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294764733 AND type='deeppockets_item' AND published='1' LIMIT 1

152 (32.901763916016): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

153 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

154 (31.948089599609): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

155 (378.13186645508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

156 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294764733 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294764733 AND published='1' LIMIT 1

157 (!!!!! 1444.1013336182): select jos_twitters.link from jos_twitters where cat=10

158 (37.193298339844): select jos_facebook.link from jos_facebook where cat=10

159 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

160 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

161 (337.83912658691): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

162 (!!!!! 1211.1663818359): insert into jos_banners_delta values (14615,'2025-06-20 15:43:16','216.73.216.120','view'),(14202,'2025-06-20 15:43:16','216.73.216.120','view'),(14203,'2025-06-20 15:43:16','216.73.216.120','view')

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