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fMRI Could Help Identify New Painkillers

By MedImaging International staff writers
Posted on 10 Feb 2016

Measuring the brain's neural response to pain using functional magnetic resonance imaging (fMRI) may be a viable tool for evaluating the effectiveness of new pain medications, according to a new study.

Researchers at John Radcliffe Hospital (Oxford, United Kingdom) and Oxford University (United Kingdom) conducted a double-blind, randomized study in 24 healthy volunteers on three separate occasions to assess the use of fMRI in obtaining objective outcome measures of drug differentiation. To induce pain, the researchers used capsaicin cream, a topical irritant often used to produce similar characteristics of neuropathic pain on subjects' skin.

Prior to capsaicin cream application, the subjects either received a single dose of gabapentin, which is considered effective and a first line treatment for neuropathic pain; ibuprofen, which is generally not considered an effective treatment for the condition; or a placebo. The researchers then assessed the effect the drugs or placebo had on the brain's neural response to pain using fMRI, in addition to patient-reported pain relief.

The results showed that neural activity was significantly reduced in the subjects who received gabapentin, even with extremely low subject numbers, highlighting the potential for fMRI to make a drug's effect clear in small cohorts, such as during the early stages of human drug development. This ability could provide a much-needed objective method to collect data that could prevent premature discarding of potentially beneficial therapies. The study was published in the January 2106 issue of Anesthesiology.

“Chronic pain is a very common condition. Even the most effective pain medications currently available only provide adequate pain relief, defined as a 50% reduction in pain, in one out of four patients, while some drugs, such as opioids, have significant side effects, including dependence and overuse,” said lead author Vishvarani Wanigasekera, MD, of the University of Oxford. “We believe that neuroimaging techniques, such as fMRI, can provide objective evidence that can be used as outcome measures in early drug development to enhance the efficiency of the drug development process.”

Patient-reported pain relief is the primary outcome measure used in current drug development studies to assess whether medication is effective or not. However, due to their subjective and context-dependent nature, self-reported pain perception and relief are subject to many influences. Due to the low subject population, researchers can also easily miss effective compounds that might work well in the population at large.

Related Links:
John Radcliffe Hospital
Oxford University

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64 (72.956085205078): select jos_twitters.link from jos_twitters where cat=10

65 (41.961669921875): select jos_facebook.link from jos_facebook where cat=10

66 (44.822692871094): select jos_google_plus.link from jos_google_plus where cat=10

67 (36.954879760742): select jos_linkedin.link from jos_linkedin where cat=10

68 (61.03515625): SELECT fid FROM jos_deeppockets WHERE id=294762695 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294762695 AND published='1' LIMIT 1

69 (46.014785766602): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (390.05279541016): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294762695 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (349.04479980469): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294762695 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (72.002410888672): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (92.029571533203): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (83.92333984375): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294762695 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (41.961669921875): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294762695 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (45.061111450195): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (73.19450378418): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (50.783157348633): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (113.96408081055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

105 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

106 (92.983245849609): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294762695 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (70.810317993164): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294762695 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

109 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

110 (56.028366088867): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294762695 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (647.06802368164): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294762695 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (705.00373840332): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (497.10273742676): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (164.98565673828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

115 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

116 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

117 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

118 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

119 (39.815902709961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

120 (106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

121 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

122 (381.9465637207): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 23942.947387695): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (519.99092102051): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294762695 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294762695 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 7895.9465026855): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (115.87142944336): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (318.05038452148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (43.153762817383): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (277.04238891602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (81.062316894531): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (317.81196594238): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (53.882598876953): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (276.08871459961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (52.928924560547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (502.8247833252): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (339.98489379883): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (353.09791564941): SELECT name FROM jos_deeppockets WHERE id=212

138 (50.067901611328): SELECT name FROM jos_deeppockets WHERE id=212

139 (664.94941711426): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (571.96617126465): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

142 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

143 (!!!!! 9557.9624176025): TRUNCATE TABLE jos_trademed_module

144 (104.90417480469): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294762695 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (52.928924560547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294762695 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (860.92948913574): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

149 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

150 (!!!!! 1142.0249938965): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

152 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

153 (62.942504882812): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294762695 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294762695 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (28.133392333984): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (33.140182495117): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

158 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762695 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762695 AND published='1' LIMIT 1

159 (50.067901611328): select jos_twitters.link from jos_twitters where cat=10

160 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

161 (29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10

162 (28.848648071289): select jos_linkedin.link from jos_linkedin where cat=10

163 (261.06834411621): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1137.9718780518): insert into jos_banners_delta values (14615,'2025-06-22 03:43:02','216.73.216.120','view'),(14202,'2025-06-22 03:43:02','216.73.216.120','view'),(14203,'2025-06-22 03:43:02','216.73.216.120','view')

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