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Combination of Imaging Methods Reveals Tumor Motion
By MedImaging International staff writers Posted on 20 Jan 2016
Image: Showing Lungs obtained using the hybrid approach; motion is denoted by the colored arrows (Photo courtesy of A*STAR).
A hybrid imaging approach that fuses magnetic resonance imaging (MRI) temporal information with computerized tomography (CT) can reveal lung and lung tumor motion.
Researchers at the Agency for Science, Technology and Research (A*STAR; Singapore), Nanyang Technological University (Singapore), and other institutions have developed a novel hybrid imaging approach that is based on deformable image registration (DIR) and finite element method simulation to fuse a static three dimension (3D)-CT volume, acquired while the patient held his breath, and 3D motion information extracted from a four dimension (4D)-MRI dataset, thus creating a synthetic 4D-CT dataset.
The result is images of the lungs that exhibit high spatial resolution, while at the same time accounting for lung movement due to breathing. When the researchers compared the synthetic 4D-CT dataset with the acquired 4D-CT dataset of six lung cancer patients based on 420 landmarks, the average error was less than two mm. The hybrid approach also achieved a 40% error reduction over using only DIR techniques. The study describing the new hybrid imaging technique was published in the August 2015 issue of Medical Physics.
“The method is expected to greatly assist clinicians when they target tumors in the lungs during radiotherapy,” said study author Soo Kng Teo, PhD, of A*STAR. “Encouragingly, some clinicians are thinking of applying our method to other organs, such as the liver, which also moves significantly with breathing. Also our computational method can combine information from different imaging methods to produce more comprehensive data sets.”
Cancerous tumors in the lungs are often treated by irradiating them with high-energy X-rays, but this therapy is complicated by the fact that tumors are moving targets, due to the expansion and contraction of the lungs as the patient breathes. Currently, 3D-CT provides static high-resolution images, but at the cost of high radiation; in contrast, 4D-MRI does not employ ionizing radiation and allows continuous tracking of lung motion, but its low spatial resolution yields blurred images.
Related Links: The Agency for Science, Technology and Research Nanyang Technological University
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AND id != 294743302
AND id != 294743303
AND id != 294743304
AND id != 294743305
AND id != 294743306
AND id != 294743307
AND id != 294743308
AND id != 294743309
AND id != 294743310
AND metakey != 'aacc'
ORDER BY `ordering`90
(71.048736572266): SELECT show_live FROM jos_com_show_setting LIMIT 191
(44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 192
(36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 193
(38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 194
(51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 195
(36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 196
(36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 197
(37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 198
(35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 199
(36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1100
(36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1101
(36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1102
(36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1103
(36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1104
(106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1105
(63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1106
(72.956085205078): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294762356
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1107
(741.00494384766): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294762356
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1108
(122.0703125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1109
(66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1110
(70.810317993164): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.id=294762356
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1111
(716.9246673584): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.id=294762356
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1112
(774.14512634277): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
LEFT JOIN jos_experts as ex
ON ex.id = dp.author
LEFT JOIN jos_deeppockets as dp2
ON dp2.id = dp.fid
WHERE dp.author != 0
AND dp.cat = 10
AND dp.published = 1
AND (
(dp.fid = 294743300)
OR (dp.fid = 294743301)
OR (dp.fid = 294743302)
OR (dp.fid = 294743303)
OR (dp.fid = 294743304)
OR (dp.fid = 294743305)
OR (dp.fid = 294743306)
OR (dp.fid = 294743307)
OR (dp.fid = 294743308)
OR (dp.fid = 294743309)
OR (dp.fid = 294743310)
)
ORDER BY RAND()
LIMIT 1113
(!!!!! 1572.847366333): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
LEFT JOIN jos_experts as ex
ON ex.id = dp.author
LEFT JOIN jos_deeppockets as dp2
ON dp2.id = dp.fid
WHERE dp.author != 0
AND dp.cat = 10
AND dp.published = 1
AND (
(dp.fid = 294743300)
OR (dp.fid = 294743301)
OR (dp.fid = 294743302)
OR (dp.fid = 294743303)
OR (dp.fid = 294743304)
OR (dp.fid = 294743305)
OR (dp.fid = 294743306)
OR (dp.fid = 294743307)
OR (dp.fid = 294743308)
OR (dp.fid = 294743309)
OR (dp.fid = 294743310)
)
ORDER BY RAND()
LIMIT 1114
(153.0647277832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1115
(66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1116
(72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1117
(58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1118
(60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1119
(56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1120
(87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1121
(57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1122
(591.99333190918): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`123
(!!!!! 68383.932113647): SELECT
*
FROM
jos_deeppockets
WHERE
jos_deeppockets.cat = 10
AND
jos_deeppockets.type = 'deeppockets_item'
AND
jos_deeppockets.published = 1
AND
jos_deeppockets.created + INTERVAL 14 DAY >= NOW()
ORDER BY
jos_deeppockets.hits DESC
LIMIT
7124
(!!!!! 1021.8620300293): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294762356 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294762356 AND type='deeppockets_item' AND published='1' LIMIT 1125
(!!!!! 21625.995635986): (
SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.video != ''
AND
dp.video_source != ''
AND
dp.cat = 10
AND
dp.published = 1
AND
dp.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
UNION
(
SELECT
dpa.id,
dpa.name,
dpa.title,
dpa.video,
dpa.video_source,
dpa.created
FROM
jos_deeppockets_archive AS dpa
WHERE
dpa.video != ''
AND
dpa.video_source != ''
AND
dpa.cat = 10
AND
dpa.published = 1
AND
dpa.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
ORDER BY
created DESC
LIMIT
3126
(78.201293945312): (
SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.video != ''
AND
dp.video_source != ''
AND
dp.cat = 10
AND
dp.published = 1
AND
dp.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
UNION
(
SELECT
dpa.id,
dpa.name,
dpa.title,
dpa.video,
dpa.video_source,
dpa.created
FROM
jos_deeppockets_archive AS dpa
WHERE
dpa.video != ''
AND
dpa.video_source != ''
AND
dpa.cat = 10
AND
dpa.published = 1
AND
dpa.type != 'deeppockets_item_link'
ORDER BY
created DESC
LIMIT
3
)
ORDER BY
created DESC
LIMIT
3127
(56.028366088867): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294803337
LIMIT 1128
(40.769577026367): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294803337
LIMIT 1129
(49.829483032227): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294803276
LIMIT 1130
(41.007995605469): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294803276
LIMIT 1131
(414.84832763672): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets_archive AS dp
WHERE
dp.id = 294803276
LIMIT 1132
(46.014785766602): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets_archive AS dp
WHERE
dp.id = 294803276
LIMIT 1133
(49.829483032227): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294802958
LIMIT 1134
(39.100646972656): SELECT
dp.id,
dp.name,
dp.title,
dp.video,
dp.video_source,
dp.created
FROM
jos_deeppockets AS dp
WHERE
dp.id = 294802958
LIMIT 1135
(!!!!! 2901.0772705078): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294762356
AND (type='deeppockets_item' OR type='deeppockets_item_link')
AND published='1'
LIMIT 1136
(615.83518981934): SELECT *
FROM jos_deeppockets_archive
WHERE 1=1
AND id=294762356
AND (type='deeppockets_item' OR type='deeppockets_item_link')
AND published='1'
LIMIT 1137
(52.928924560547): SELECT name FROM jos_deeppockets WHERE id=212138
(39.100646972656): SELECT name FROM jos_deeppockets WHERE id=212139
(756.02531433105): SELECT *,
DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
FROM jos_events
WHERE state=1
AND publish_up > NOW()
and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110)
ORDER BY publish_up ASC LIMIT 3140
(645.16067504883): SELECT *,
DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
FROM jos_events
WHERE state=1
AND publish_up > NOW()
and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110)
ORDER BY publish_up ASC LIMIT 3141
(89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1142
(66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1143
(!!!!! 19365.072250366): TRUNCATE TABLE jos_trademed_module144
(168.0850982666): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294762356
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1145
(74.863433837891): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
LEFT JOIN jos_experts as exp
ON exp.id = dp.author
LEFT JOIN jos_deeppockets as ch
ON dp.fid = ch.id
WHERE 1=1
AND dp.cat=10
AND dp.id=294762356
AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
AND dp.published='1' LIMIT 1146
(!!!!! 1210.9279632568): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294762356
AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1147
(82.015991210938): SELECT *
FROM jos_deeppockets
WHERE 1=1
AND id=294762356
AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1148
(77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1149
(61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1150
(!!!!! 4759.7885131836): SELECT jos_item.*
FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id
WHERE 1=1
AND (jos_item.imgMini<>'')
AND jos_item.type='L'
AND jos_item.numberID= (
SELECT jos_number.id
FROM jos_number
WHERE jos_number.journalID IN (10)
and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P')
ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC
LIMIT 0,1
)
ORDER BY RAND() DESC LIMIT 6151
(87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1152
(65.803527832031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1153
(44.107437133789): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294762356 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294762356 AND type='deeppockets_item' AND published='1' LIMIT 1154
(41.961669921875): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=212 or channel_id is null)155
(38.14697265625): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=212 or channel_id is null)156
(43.153762817383): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1157
(100.85105895996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1158
(61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294762356 AND published='1'
union
SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294762356 AND published='1'
LIMIT 1159
(56.982040405273): select jos_twitters.link from jos_twitters where cat=10160
(38.14697265625): select jos_facebook.link from jos_facebook where cat=10161
(39.100646972656): select jos_google_plus.link from jos_google_plus where cat=10162
(72.002410888672): select jos_linkedin.link from jos_linkedin where cat=10163
(429.15344238281): update jos_bannersmanager_banner
set impmade=impmade+1
where id in(14615,14202,14203)164
(!!!!! 1316.0705566406): insert into jos_banners_delta values (14615,'2025-08-28 18:35:07','216.73.216.120','view'),(14202,'2025-08-28 18:35:07','216.73.216.120','view'),(14203,'2025-08-28 18:35:07','216.73.216.120','view')
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