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27 Jul 2025 - 30 Jul 2025

AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Technique Developed to Help Clinicians Treat Early Brain Glioma Tumors

By MedImaging International staff writers
Posted on 27 Dec 2015

A new technique for detecting and treating deadly brain tumors earlier using a nanotechnology Magnetic Resonance Imaging (MRI) contrast agent has been developed.

The agent can pass through the blood-brain barrier and provides opportunities to treat normally fatal gliomas. Patients with cancerous gliomas have a median survival rate of 14 months after they are diagnosed.

The new approach was developed by researchers at the Department of Neurosurgery of Penn State College of Medicine (Hershey, PA, USA), and was published in the Journal of Neuro-Oncology.

Current treatment options for patients with malignant glioma are surgery, chemotherapy, radiation therapy but the cancer often returns, surviving initial treatments, and follow-up MRI scans often are unable to catch the tumors in time. Existing MRI contrast agents can only find tumors after they are large enough to damage the blood-brain barrier. The Penn State research team found a way to created "smart fat cells" or liposomes that are able to pass the blood-brain barrier in mice, and find cancerous gliomas earlier. The liposomes work together with Magnevist, a common MRI contrast agent, and are also studded with proteins that target receptors on glioma cells. According to the researchers, smart fat cells may be used in the future to deliver chemotherapeutic drugs, and contrast agents, to brain tumor patients, to detect and remove cancer cells.

James Connor, distinguished professor of neurosurgery, said "Patients typically don't die from the tumor they initially presented with. Rather, they die from new tumors that come back in other parts of the brain. The goal is to be able to get down to detecting single cancer cells. Ultrasound, with all of its good qualities, is disruptive to the blood-brain barrier, whereas we can get an agent to cross it without causing disruption."

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			AND
				`site_id` = 10
			AND
				`published` = 143
(!!!!! 6156.9213867188): SELECT
				*
			FROM
				jos_bannersmanager_banner
			WHERE
				`groupid` = 99
			AND
				`site_id` = 10
			AND
				`published` = 144
(226.02081298828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 145
(124.93133544922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 146
(233.17337036133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 147
(113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 148
(99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 149
(61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 150
(121.8318939209): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 151
(139.95170593262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 152
(514.03045654297): SELECT name FROM jos_deeppockets WHERE id=294761949 LIMIT 153
(475.88348388672): SELECT name FROM jos_deeppockets_archive WHERE id=294761949 LIMIT 154
(75.101852416992): SELECT a.*
 FROM jos_components AS a
 WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' )
 AND a.option = 'com_syndicate'55
(92.029571533203): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294761949
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 156
(799.17907714844): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294761949
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 157
(!!!!! 3356.93359375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 158
(!!!!! 3262.0429992676): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 159
(!!!!! 2394.9146270752): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 160
(135.89859008789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 161
(!!!!! 3082.0369720459): select cover from jos_number
where journalid in (5) and cover is not null
order by left(issue,2)+right(issue,2)*12 desc limit 162
(!!!!! 3141.8800354004): SELECT fid FROM jos_deeppockets WHERE id=294761949 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294761949 AND published='1'  LIMIT 163
(!!!!! 1531.1241149902): SELECT id,name,sponsor_text
                    FROM jos_deeppockets dp
					left outer join jos_channel_sponsor cs
					on dp.id=cs.fid
                    WHERE cat=10
                    AND TYPE='file_folder'
                    AND published=1
                    AND id=212
                    ORDER BY `ordering`64
(!!!!! 1830.1010131836): select jos_twitters.link from jos_twitters where cat=1065
(61.988830566406): select jos_facebook.link from jos_facebook where cat=1066
(43.869018554688): select jos_google_plus.link from jos_google_plus where cat=1067
(39.100646972656): select jos_linkedin.link from jos_linkedin where cat=1068
(465.86990356445): SELECT fid FROM jos_deeppockets WHERE id=294761949 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294761949 AND published='1'  LIMIT 169
(47.922134399414): SELECT id,name,sponsor_text
                    FROM jos_deeppockets dp
					left outer join jos_channel_sponsor cs
					on dp.id=cs.fid
                    WHERE cat=10
                    AND TYPE='file_folder'
                    AND published=1
                    AND id=212
                    ORDER BY `ordering`70
(!!!!! 1309.1564178467): SELECT fid FROM jos_deeppockets
								WHERE cat=10
								AND id=294761949
								AND (type='deeppockets_item' OR type='deeppockets_item_link') 
								AND published='1' 
								LIMIT 171
(533.8191986084): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294761949 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 172
(56.028366088867): SELECT id,name,title
 FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
			AND id != 294743300
			AND id != 294743301
			AND id != 294743302
			AND id != 294743303
			AND id != 294743304
			AND id != 294743305
			AND id != 294743306
			AND id != 294743307
			AND id != 294743308
			AND id != 294743309
			AND id != 294743310
			AND metakey != 'aacc'
		ORDER BY `ordering`73
(85.115432739258): SELECT show_live FROM jos_com_show_setting LIMIT 174
(43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 175
(!!!!! 3499.9847412109): SELECT show_live FROM jos_com_show_setting LIMIT 176
(92.983245849609): SELECT show_live FROM jos_com_show_setting LIMIT 177
(432.96813964844): SELECT show_live FROM jos_com_show_setting LIMIT 178
(55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 179
(50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 180
(41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 181
(897.88436889648): SELECT show_live FROM jos_com_show_setting LIMIT 182
(54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 183
(41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 184
(37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 185
(!!!!! 1720.9053039551): SELECT show_live FROM jos_com_show_setting LIMIT 186
(160.21728515625): SELECT show_live FROM jos_com_show_setting LIMIT 187
(328.06396484375): SELECT fid FROM jos_deeppockets
								WHERE cat=10
								AND id=294761949
								AND (type='deeppockets_item' OR type='deeppockets_item_link') 
								AND published='1' 
								LIMIT 188
(51.975250244141): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294761949 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 189
(279.90341186523): SELECT id,name,title
 FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
			AND id != 294743300
			AND id != 294743301
			AND id != 294743302
			AND id != 294743303
			AND id != 294743304
			AND id != 294743305
			AND id != 294743306
			AND id != 294743307
			AND id != 294743308
			AND id != 294743309
			AND id != 294743310
			AND metakey != 'aacc'
		ORDER BY `ordering`90
(115.15617370605): SELECT show_live FROM jos_com_show_setting LIMIT 191
(48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 192
(46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 193
(38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 194
(51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 195
(37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 196
(36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 197
(!!!!! 2799.0341186523): SELECT show_live FROM jos_com_show_setting LIMIT 198
(113.01040649414): SELECT show_live FROM jos_com_show_setting LIMIT 199
(44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1100
(64.849853515625): SELECT show_live FROM jos_com_show_setting LIMIT 1101
(41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1102
(!!!!! 3576.0402679443): SELECT show_live FROM jos_com_show_setting LIMIT 1103
(106.0962677002): SELECT show_live FROM jos_com_show_setting LIMIT 1104
(!!!!! 1710.8917236328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1105
(272.03559875488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1106
(97.036361694336): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294761949
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1107
(764.84680175781): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294761949
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1108
(!!!!! 5982.8758239746): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1109
(156.87942504883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1110
(108.95729064941): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							
							AND dp.id=294761949
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1111
(768.89991760254): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								
								AND dp.id=294761949
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1112
(883.10241699219): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as ex
							ON ex.id = dp.author
							LEFT JOIN jos_deeppockets as dp2
							ON dp2.id = dp.fid
							WHERE dp.author != 0
							AND dp.cat = 10
							AND dp.published = 1
							AND (
								(dp.fid = 294743300)
								OR (dp.fid = 294743301)
								OR (dp.fid = 294743302)
								OR (dp.fid = 294743303)
								OR (dp.fid = 294743304)
								OR (dp.fid = 294743305)
								OR (dp.fid = 294743306)
								OR (dp.fid = 294743307)
								OR (dp.fid = 294743308)
								OR (dp.fid = 294743309)
								OR (dp.fid = 294743310)
								)
							ORDER BY RAND()
							LIMIT 1113
(656.8431854248): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as ex
							ON ex.id = dp.author
							LEFT JOIN jos_deeppockets as dp2
							ON dp2.id = dp.fid
							WHERE dp.author != 0
							AND dp.cat = 10
							AND dp.published = 1
							AND (
								(dp.fid = 294743300)
								OR (dp.fid = 294743301)
								OR (dp.fid = 294743302)
								OR (dp.fid = 294743303)
								OR (dp.fid = 294743304)
								OR (dp.fid = 294743305)
								OR (dp.fid = 294743306)
								OR (dp.fid = 294743307)
								OR (dp.fid = 294743308)
								OR (dp.fid = 294743309)
								OR (dp.fid = 294743310)
								)
							ORDER BY RAND()
							LIMIT 1114
(159.02519226074): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1115
(79.870223999023): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1116
(136.13700866699): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1117
(54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1118
(50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1119
(40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1120
(106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1121
(66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1122
(591.99333190918): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`123
(!!!!! 48835.039138794): SELECT
				*
			FROM
				jos_deeppockets
			WHERE
				jos_deeppockets.cat = 10
			AND
				jos_deeppockets.type = 'deeppockets_item'
			AND
				jos_deeppockets.published = 1
			AND
				jos_deeppockets.created + INTERVAL 14 DAY >= NOW()
			ORDER BY
				jos_deeppockets.hits DESC
			LIMIT
				7124
(876.90353393555): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294761949 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294761949 AND type='deeppockets_item' AND published='1'  LIMIT 1125
(!!!!! 17054.080963135): (
				SELECT
					dp.id,
					dp.name,
					dp.title,
					dp.video,
					dp.video_source,
					dp.created

				FROM
					jos_deeppockets AS dp

				WHERE
					dp.video != ''
				AND
					dp.video_source != ''
				AND
					dp.cat = 10
				AND
					dp.published = 1
				AND
					dp.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			UNION
			(
				SELECT
					dpa.id,
					dpa.name,
					dpa.title,
					dpa.video,
					dpa.video_source,
					dpa.created

				FROM
					jos_deeppockets_archive AS dpa

				WHERE
					dpa.video != ''
				AND
					dpa.video_source != ''
				AND
					dpa.cat = 10
				AND
					dpa.published = 1
				AND
					dpa.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			ORDER BY
				created DESC

			LIMIT
				3126
(49.114227294922): (
				SELECT
					dp.id,
					dp.name,
					dp.title,
					dp.video,
					dp.video_source,
					dp.created

				FROM
					jos_deeppockets AS dp

				WHERE
					dp.video != ''
				AND
					dp.video_source != ''
				AND
					dp.cat = 10
				AND
					dp.published = 1
				AND
					dp.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			UNION
			(
				SELECT
					dpa.id,
					dpa.name,
					dpa.title,
					dpa.video,
					dpa.video_source,
					dpa.created

				FROM
					jos_deeppockets_archive AS dpa

				WHERE
					dpa.video != ''
				AND
					dpa.video_source != ''
				AND
					dpa.cat = 10
				AND
					dpa.published = 1
				AND
					dpa.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			ORDER BY
				created DESC

			LIMIT
				3127
(516.89147949219): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294803337

			LIMIT 1128
(47.922134399414): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294803337

			LIMIT 1129
(395.05958557129): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294803276

			LIMIT 1130
(343.08433532715): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294803276

			LIMIT 1131
(291.10908508301): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets_archive AS dp

			WHERE
				dp.id = 294803276

			LIMIT 1132
(873.08883666992): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets_archive AS dp

			WHERE
				dp.id = 294803276

			LIMIT 1133
(39.815902709961): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294802958

			LIMIT 1134
(30.040740966797): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294802958

			LIMIT 1135
(!!!!! 6058.2160949707): SELECT *
                            FROM jos_deeppockets
                            WHERE 1=1 
                              AND id=294761949
                              AND (type='deeppockets_item' OR type='deeppockets_item_link')
                              AND published='1'
                            LIMIT 1136
(605.10635375977): SELECT *
                            FROM jos_deeppockets_archive
                            WHERE 1=1 
                              AND id=294761949
                              AND (type='deeppockets_item' OR type='deeppockets_item_link')
                              AND published='1'
                            LIMIT 1137
(299.93057250977): SELECT name FROM jos_deeppockets WHERE id=212138
(52.928924560547): SELECT name FROM jos_deeppockets WHERE id=212139
(685.9302520752): SELECT *,
    DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
    DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
    FROM jos_events
    WHERE state=1
    AND publish_up > NOW()
    and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) 
    ORDER BY publish_up ASC LIMIT 3140
(498.05641174316): SELECT *,
    DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
    DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
    FROM jos_events
    WHERE state=1
    AND publish_up > NOW()
    and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) 
    ORDER BY publish_up ASC LIMIT 3141
(75.817108154297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1142
(48.160552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1143
(!!!!! 13198.137283325): TRUNCATE TABLE jos_trademed_module144
(102.99682617188): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294761949
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1145
(149.96528625488): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294761949
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1146
(!!!!! 1892.08984375): SELECT *
   FROM jos_deeppockets
   WHERE 1=1 
   AND id=294761949
   AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1147
(101.08947753906): SELECT *
   FROM jos_deeppockets
   WHERE 1=1 
   AND id=294761949
   AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1148
(100.85105895996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1149
(65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1150
(!!!!! 7486.10496521): SELECT jos_item.*
						FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id
						WHERE 1=1
						AND (jos_item.imgMini<>'')
						AND jos_item.type='L'
						AND jos_item.numberID= (
									 SELECT jos_number.id
									 FROM jos_number
									 WHERE jos_number.journalID IN (10)
						
									and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P')
									 ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC
									 LIMIT 0,1
									 )
						ORDER BY RAND() DESC LIMIT 6151
(149.01161193848): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1152
(86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1153
(41.961669921875): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294761949 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294761949 AND type='deeppockets_item' AND published='1'  LIMIT 1154
(36.001205444336): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=212 or channel_id is null)155
(31.948089599609): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=212 or channel_id is null)156
(41.961669921875): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1157
(128.03077697754): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1158
(53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294761949 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294761949 AND published='1'
		LIMIT 1159
(63.896179199219): select jos_twitters.link from jos_twitters where cat=10160
(30.040740966797): select jos_facebook.link from jos_facebook where cat=10161
(!!!!! 3468.0366516113): select jos_google_plus.link from jos_google_plus where cat=10162
(!!!!! 3085.8516693115): select jos_linkedin.link from jos_linkedin where cat=10163
(416.99409484863): update jos_bannersmanager_banner
			set impmade=impmade+1
			where id in(14615,14202,14203)164
(!!!!! 1518.9647674561): insert into jos_banners_delta values (14615,'2025-06-22 11:41:20','216.73.216.120','view'),(14202,'2025-06-22 11:41:20','216.73.216.120','view'),(14203,'2025-06-22 11:41:20','216.73.216.120','view')

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