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Preventing Unnecessary Breast Biopsies Using MRI

By MedImaging International staff writers
Posted on 30 Sep 2015

The results of a new study have shown that a new Magnetic Resonance (MR) breast imaging technique could prevent unnecessary biopsies.

The new technique, called Diffusion-Weighted Imaging with Background Suppression Magnetic Resonance Mammography (DWIBS-MRM), can be used to assess the diffusion of water molecules within tissue. Diffusion could be restricted by malignant tumors for example. The results of the study were published in the online version of the journal Radiology.

DWIBS-MRM could be used to provide additional information for clinicians about suspicious findings discovered during X-Ray mammography screening. Conventional X-Ray mammography in itself can save lives, but often results in a high false-positive rate that leads to unnecessary biopsies.

DWIBS-MRM uses an abbreviated MR breast imaging protocol, and does not require the use of a contrast agent. The protocol shows the shape, and appearance of the lesion, and its biophysiological properties. A full breast MR protocol takes more than 30 minutes, while DWIBS-MRM images take less than 7 minutes, with a mean reading time of less than 30 seconds.

The study included 50 women with suspicious screening mammograms, and an indication for biopsy. The researchers compared a full diagnostic breast MR protocol, abbreviated contrast-enhanced MRI, and the new DWIBS-MRM technique. A breast carcinoma was found in 24 women.

The DWIBS-MRM technique was found to be as accurate as abbreviated contrast-enhanced and full diagnostic MRI protocols and resulted in a negative predictive value of 92%. However none of the MR techniques were able to detect pure microcalcification-related Ductal Carcinoma In-Situ (DCIS), without solid tumor.

Lead author of the study, Sebastian Bickelhaupt, MD, radiologist, German Cancer Research Center (Heidelberg, Germany), said, “If the preliminary findings are confirmed, this approach could have a high potential to be used as an adjunct in the clarification process of unclear lesions on X-Ray mammography in breast cancer screening. This might help to reduce the number of invasive biopsies and the related anxiety in women who have suspicious findings at mammography.”

Related Links:
Radiological Society of North America (RSNA)
German Cancer Research Center

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64 (!!!!! 3169.059753418): select jos_twitters.link from jos_twitters where cat=10

65 (527.14347839355): select jos_facebook.link from jos_facebook where cat=10

66 (!!!!! 7205.9631347656): select jos_google_plus.link from jos_google_plus where cat=10

67 (40.054321289062): select jos_linkedin.link from jos_linkedin where cat=10

68 (69.141387939453): SELECT fid FROM jos_deeppockets WHERE id=294760644 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294760644 AND published='1' LIMIT 1

69 (80.82389831543): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (507.11631774902): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294760644 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (360.01205444336): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294760644 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (!!!!! 5929.9468994141): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (142.81272888184): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (59.127807617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (118.01719665527): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (!!!!! 3928.8997650146): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (173.09188842773): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (53.167343139648): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (50.783157348633): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 26558.876037598): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294760644 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (!!!!! 4204.0348052979): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294760644 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (192.88063049316): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (86.069107055664): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (!!!!! 1255.989074707): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (82.015991210938): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (!!!!! 3675.9376525879): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (136.13700866699): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 15266.895294189): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

105 (!!!!! 7678.0319213867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

106 (108.00361633301): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294760644 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (!!!!! 3139.0190124512): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294760644 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 8213.996887207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

109 (!!!!! 7984.8766326904): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

110 (81.777572631836): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294760644 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (677.82402038574): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294760644 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (977.0393371582): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (478.02925109863): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 1861.8106842041): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

115 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

116 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

117 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

118 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

119 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

120 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

121 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

122 (390.05279541016): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 79167.127609253): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (672.1019744873): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294760644 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294760644 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 22561.073303223): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 8329.8683166504): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 4141.092300415): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (72.002410888672): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (668.04885864258): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (230.07392883301): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (351.90582275391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (267.02880859375): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (371.93298339844): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (259.8762512207): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 3413.9156341553): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (530.00450134277): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (!!!!! 8790.0161743164): SELECT name FROM jos_deeppockets WHERE id=212

138 (319.9577331543): SELECT name FROM jos_deeppockets WHERE id=212

139 (!!!!! 2081.8710327148): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (!!!!! 1648.1876373291): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 2029.1805267334): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

142 (337.12387084961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

143 (!!!!! 27709.9609375): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 11138.916015625): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294760644 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (!!!!! 15894.889831543): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294760644 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 2915.8592224121): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (!!!!! 12049.913406372): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 11699.914932251): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

149 (!!!!! 8259.7732543945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

150 (!!!!! 4270.076751709): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 2732.0384979248): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

152 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

153 (!!!!! 2369.1654205322): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294760644 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294760644 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (56.982040405273): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (231.98127746582): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (206.94732666016): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 7344.9611663818): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

158 (302.07633972168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294760644 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294760644 AND published='1' LIMIT 1

159 (714.77890014648): select jos_twitters.link from jos_twitters where cat=10

160 (95.844268798828): select jos_facebook.link from jos_facebook where cat=10

161 (403.88107299805): select jos_google_plus.link from jos_google_plus where cat=10

162 (!!!!! 3479.9575805664): select jos_linkedin.link from jos_linkedin where cat=10

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