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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Imaging Test Designed for Autism Spectrum Disorder

By MedImaging International staff writers
Posted on 27 Jan 2015

Scientists have developed a brain-imaging technique that may be able to identify children with autism spectrum disorder in just two minutes. Typically, diagnosis—an unquantifiable process based on clinical judgment—is time-consuming and tiresome on children and their families. That may change with this new diagnostic test.

This imaging modality, while not ready to be used as the clinical standard of care, offers huge diagnostic potential once it undergoes more research and evaluation. “Our brains have a perspective-tracking response that monitors, for example, whether it’s your turn or my turn,” said Read Montague, the Virginia Tech Carilion Research Institute (Roanoke, VA, USA) professor who led the study. “This response is removed from our emotional input, so it makes a great quantitative marker,” he said. “We can use it to measure differences between people with and without autism spectrum disorder.”

The finding, slated for online publication in January 2015 in the journal Clinical Psychological Science, revealed that the perspective-tracking response can be used to determine whether someone has autism spectrum disorder. The path to this discovery has been a long, iterative one. In a 2006 study by Prof. Montague and others, pairs of subjects had their brains scanned using functional magnetic resonance imaging (fMRI), as they played a game requiring them to take turns. From those images, researchers found that the middle cingulate cortex became more active when it was the subject’s turn.

“A response in that part of the brain is not an emotional response, and we found that intriguing,” said Prof. Montague, who also directs the computational psychiatry unit at the Virginia Tech Carilion Research Institute and is a professor of physics at Virginia Tech. “We realized the middle cingulate cortex is responsible for distinguishing between self and others, and that's how it was able to keep track of whose turn it was.”

That recognition led the scientists to investigate how the middle cingulate cortex response differs in individuals at different developmental levels. In a 2008 study, Prof. Montague and his colleagues asked athletes to watch a brief clip of a physical action, such as kicking a ball or dancing, while undergoing fMRI.

The athletes were then asked either to replay the clips in their mind, like watching a movie, or to imagine themselves as participants in the clips. “The athletes had the same responses as the game participants from our earlier study,” Prof. Montague said. “The middle cingulate cortex was active when they imagined themselves dancing—in other words, when they needed to recognize themselves in the action.”

In the 2008 study, the researchers also discovered that in participants with autism spectrum disorder, the more passive the response is, the more severe the symptoms. Montague and his team theorized that a clear biomarker for self-perspective exists and that they could track it using functional MRI. They also conjectured that the biomarker could be used as an application in the clinical diagnosis of people with autism spectrum disorder.

In 2012, the scientists designed another examine to see whether they could elicit a brain response to help them compute the indefinable. By presenting self-images while scanning the brains of adults, they elicited the self-perspective response they had previously observed in social interaction games.

In the current study, with children, the study participants were shown 15 images of themselves and 15 images of a child correlated for age and gender for four seconds per image in a random order. Similar to the control adults, the control children had a high response in the middle cingulate cortex when viewing their own images. By contrast, children with autism spectrum disorder had a significantly diminished response. Most notably, the investigators could detect this difference in individuals using only a single image.

The researchers realized they had developed a single-stimulus functional MRI diagnostic technique. The single-stimulus part is important, Prof. Montague emphasized, as it enables speed. Children with autism spectrum disorder cannot stay in the scanner for long, so the test must be fast. “We went from a slow, average depiction of brain activity in a cognitive challenge to a quick test that is significantly easier for children to do than spend hours under observation,” Prof. Montague said. “The single-stimulus functional MRI could also open the door to developing MRI-based applications for screening of other cognitive disorders.”

By mapping psychological disparities through brain scans, scientists are adding a critical component to the typical process of neuropsychiatric diagnosis: math. Prof. Montague has been a pioneering figure in this field, which he termed computational psychiatry. The idea is that scientists can tie the function of mental disorders to the disrupted processes of neural tissue through mathematic approaches. Clinicians then can use measurable data for earlier diagnosis and treatment.

An earlier diagnosis can also have a great impact on the children and their families, Prof. Montague said. “The younger children are at the time of diagnosis,” he concluded, “the more they can benefit from a range of therapies that can transform their lives.”

Related Links:
Virginia Tech Carilion Research Institute

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56 (663.99574279785): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294756934 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

57 (!!!!! 1399.040222168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

58 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

59 (110.86463928223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

60 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

61 (130.89179992676): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (629.90188598633): SELECT fid FROM jos_deeppockets WHERE id=294756934 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294756934 AND published='1' LIMIT 1

63 (50.067901611328): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (50.783157348633): select jos_twitters.link from jos_twitters where cat=10

65 (33.855438232422): select jos_facebook.link from jos_facebook where cat=10

66 (36.001205444336): select jos_google_plus.link from jos_google_plus where cat=10

67 (34.093856811523): select jos_linkedin.link from jos_linkedin where cat=10

68 (39.100646972656): SELECT fid FROM jos_deeppockets WHERE id=294756934 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294756934 AND published='1' LIMIT 1

69 (36.001205444336): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (368.11828613281): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294756934 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (298.97689819336): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294756934 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (44.107437133789): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (45.061111450195): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294756934 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294756934 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (31.948089599609): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

105 (45.7763671875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

106 (72.956085205078): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294756934 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (67.949295043945): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294756934 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (96.797943115234): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

109 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

110 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294756934 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (688.79127502441): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294756934 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (681.87713623047): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (479.93659973145): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (184.05914306641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

115 (85.830688476562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

116 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

117 (101.80473327637): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

118 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

119 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

120 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

121 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

122 (343.79959106445): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 21185.159683228): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (594.8543548584): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294756934 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294756934 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 7323.0266571045): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (72.956085205078): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (61.03515625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (51.021575927734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (29.802322387695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (356.19735717773): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (711.91787719727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (515.93780517578): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (69.141387939453): SELECT name FROM jos_deeppockets WHERE id=212

138 (43.153762817383): SELECT name FROM jos_deeppockets WHERE id=212

139 (751.97219848633): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (766.03889465332): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (111.10305786133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

142 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

143 (!!!!! 8584.0225219727): TRUNCATE TABLE jos_trademed_module

144 (89.883804321289): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294756934 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (92.983245849609): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294756934 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (793.9338684082): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (59.127807617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

149 (48.160552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

150 (!!!!! 1218.0805206299): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

152 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

153 (89.883804321289): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294756934 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294756934 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (26.941299438477): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (40.054321289062): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (136.13700866699): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

158 (83.208084106445): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294756934 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294756934 AND published='1' LIMIT 1

159 (41.961669921875): select jos_twitters.link from jos_twitters where cat=10

160 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

161 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

162 (31.948089599609): select jos_linkedin.link from jos_linkedin where cat=10

163 (281.09550476074): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1046.895980835): insert into jos_banners_delta values (14615,'2025-06-23 08:48:56','216.73.216.120','view'),(14202,'2025-06-23 08:48:56','216.73.216.120','view'),(14203,'2025-06-23 08:48:56','216.73.216.120','view')

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