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MRI Technology Designed for Diagnosing Painful Back Disorder

By MedImaging International staff writers
Posted on 06 Oct 2014

A new imaging technique used to identify biomarkers could indicate which patients have a painful, degenerative back condition is under development.

An interdisciplinary research team in the Cedars-Sinai Biomedical Imaging Research Institute (Los Angeles, CA, USA) department of biomedical sciences, Regenerative Medicine Institute and department of surgery received a grant from the US National Institutes of Health (NIH; Bethesda, MD, USA) to develop the technology.

Biomarkers are specific body substances, such as body fluids or fluids that can indicate specific health conditions. When noninvasive imaging modalities, such as magnetic resonance imaging (MRI), can identify exactly where the biomarkers are, researchers may alleviate the need for painful and invasive diagnostic procedures, and in the future, provide targeted, stem cell-based therapies to patients with the condition.

More than 85% of people in the United States alone suffer from low back pain, much of which is caused by intervertebral disc degeneration. Disc degeneration is a progressive condition, resulting in chronic pain in the back and neck. For some patients, degeneration can occur long before pain sets in, presenting symptoms, while others are affected almost immediately.

As described April 2014 in an article in the journal Magnetic Resonance in Medicine, identifying the exact disc that is the source of pain by employing the most sophisticated imaging techniques may save patients from painful and invasive diagnostic procedures, such as procedures in which physicians inject a contrast agent or non-toxic dye into patients’ spinal discs.

“The goal of our institute is to develop and apply novel imaging techniques that translate to clinical significance,” said Debiao Li, PhD, director of the Biomedical Imaging Research Institute, corresponding author of the article and a co-principal investigator on the NIH grant. “This imaging technology may allow us to do just this. By mapping a patient’s lower spinal region, we can identify the discs causing discomfort, which allows physicians to then treat accordingly.”

In the study, investigators developed various imaging techniques using MRI scanning, which can identify specific biomarkers to potentially provide a noninvasive diagnostic approach to intervertebral disc degeneration. The application, which has been evaluated on patients and in the laboratory, enabled researchers to exactly target the origin of pain and monitor the progression of each patient’s condition.

With this imaging technique, investigators in the Regenerative Medicine Institute are trying to generate a stem cell-based therapeutic agent for patients suffering from the degenerative disorder. “Our research team is interested in the role of stem cells in this disease and how we can utilize these cells to regenerate the disc and turn it back into a functional tissue,” said Dan Gazit, PhD, co-principal investigator on the grant and director of the skeletal regeneration and stem cell therapy laboratory in the department of surgery, the skeletal program in the Regenerative Medicine Institute and the molecular- and micro-imaging core facility. “Using this novel imaging technique, we will be able to evaluate the effect of our future stem cell therapies on back pain.”

Hyun Bae, MD, medical director of orthopedic spine surgery and director of spine education, who is co-investigator of the study, said, “By understanding where the source of pain comes from, physicians can better utilize surgical and non-surgical treatments to help patients live a more normal lifestyle.”

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Cedars-Sinai Biomedical Imaging Research Institute

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60 (664.94941711426): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

61 (131.84547424316): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (!!!!! 1501.0833740234): SELECT fid FROM jos_deeppockets WHERE id=294754977 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294754977 AND published='1' LIMIT 1

63 (!!!!! 2720.1175689697): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (!!!!! 2345.8003997803): select jos_twitters.link from jos_twitters where cat=10

65 (370.97930908203): select jos_facebook.link from jos_facebook where cat=10

66 (46.014785766602): select jos_google_plus.link from jos_google_plus where cat=10

67 (360.01205444336): select jos_linkedin.link from jos_linkedin where cat=10

68 (335.9317779541): SELECT fid FROM jos_deeppockets WHERE id=294754977 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294754977 AND published='1' LIMIT 1

69 (393.15223693848): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (651.12113952637): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754977 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (!!!!! 1549.9591827393): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754977 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (787.01972961426): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (131.84547424316): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (!!!!! 4053.8311004639): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (873.80409240723): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (!!!!! 1017.8089141846): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (438.21334838867): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (509.97734069824): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (298.97689819336): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754977 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (262.02201843262): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754977 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (!!!!! 1755.952835083): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 2067.0890808105): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (!!!!! 2482.1758270264): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (865.93627929688): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (!!!!! 1690.149307251): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (!!!!! 1352.071762085): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (!!!!! 1654.1481018066): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (58.889389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (412.94097900391): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (!!!!! 1368.9994812012): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (612.02049255371): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (569.82040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (288.96331787109): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (450.84953308105): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (954.86640930176): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 2182.9605102539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

105 (283.00285339355): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

106 (719.07043457031): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754977 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (!!!!! 15145.063400269): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754977 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 2917.0513153076): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

109 (693.08280944824): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

110 (!!!!! 2774.9538421631): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294754977 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 3066.0629272461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294754977 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 1162.052154541): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (983.95347595215): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (!!!!! 4670.1431274414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

115 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

116 (355.00526428223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

117 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

118 (754.83322143555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

119 (426.05400085449): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

120 (!!!!! 8774.995803833): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

121 (581.02607727051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

122 (413.89465332031): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 51436.901092529): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (808.9542388916): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754977 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754977 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 16494.035720825): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (394.10591125488): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 1768.1121826172): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (!!!!! 3208.1604003906): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (56.982040405273): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (355.00526428223): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (543.83277893066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (658.03527832031): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (!!!!! 1068.115234375): SELECT name FROM jos_deeppockets WHERE id=212

138 (49.114227294922): SELECT name FROM jos_deeppockets WHERE id=212

139 (768.89991760254): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (!!!!! 1679.8973083496): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 2994.0605163574): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

142 (182.8670501709): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

143 (!!!!! 14950.99067688): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 1654.8633575439): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754977 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (789.16549682617): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754977 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 11490.106582642): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (144.00482177734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

149 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

150 (!!!!! 1601.9344329834): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 1430.9883117676): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

152 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

153 (!!!!! 1314.8784637451): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754977 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754977 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (!!!!! 1836.0614776611): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (214.81513977051): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (387.90702819824): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 3655.1952362061): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

158 (!!!!! 5557.0602416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754977 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754977 AND published='1' LIMIT 1

159 (53.882598876953): select jos_twitters.link from jos_twitters where cat=10

160 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

161 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

162 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10

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