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fMRI Shows Earlier Depression Can Lead to Hyperconnected Brain Networks in Young Adults

By MedImaging International staff writers
Posted on 09 Sep 2014

Image: Rachel Jacobs, UIC research assistant professor in psychiatry, and Scott Langenecker, UIC associate professor of psychiatry and psychology, use functional magnetic resonance imaging to examine the brain connectivity of young adults (Photo courtesy of Joshua Clark/UIC Photo Services).

Image: Connectivity of left posterior cingulate seed and between group differences. Panel A: Connectivities among HC youth illustrate the default mode network. Panel B: Youth with remitted depression demonstrated greater connectivity with the right insula, superior and middle frontal gyrus, putamen, angular gyrus, and left middle frontal gyrus (Photo courtesy of Plos One journal).

Depression may be better predicted and understood now that researchers have discovered through neuroimaging that young adults who had previously suffered from depression have hyper-connected emotional and cognitive networks in the brain.

University of Illinois at Chicago (USA) researchers used functional magnetic resonance imaging (fMRI) to study the brain connectivity of young adults ages 18 to 23 while they were in a resting state. Thirty unmedicated young adults who had earlier experienced depression and 23 healthy control subjects were used in the study, which was published August 27, 2014, online in the journal PLOS ONE.

“We wanted to see if the individuals who have had depression during their adolescence were different from their healthy peers,” said Rachel Jacobs, research assistant professor in psychiatry at UIC’s Institute for Juvenile Research, the lead author of the study.

The researchers found many brain areas that are “hyper-connected—or talking to each other a little too much—among those who have a history of depression,” Dr. Jacobs said. These hyper-connected brain networks were associated with rumination, with individuals thinking about a problem over and over without actively trying to come up with a solution.

“Rumination is not a very healthy way of processing emotion,” said Scott Langenecker, associate professor of psychiatry and psychology at UIC and corresponding author of the study. “Rumination is a risk factor for depression and for reoccurrence of depression if you’ve had it in the past.”

The investigators also examined at cognitive control (the ability to engage and disengage in thought processes or behaviors), which is a predictor of response to treatment and also relapse of illness. “Cognitive control and rumination, as you might expect, are related to each other. As rumination goes up, cognitive control goes down,” said Dr. Langenecker.

The researchers will continue to track these young adults over time to see whether or not these hyperconnectivities predict who will or will not have a recurrence of illness. Psychosocial and medication treatments for depression can be helpful, according to Dr. Jacobs, but within two years of recovery 50% of those teenagers will relapse.

The move towards adulthood, a time when brain networks are almost mature, may be a critical window for interventions. “If we can help youth learn how to shift out of maladaptive strategies such as rumination, this may protect them from developing chronic depression and help them stay well as adults,” Dr. Jacobs said.

“We think that depression is a developmental outcome, and it’s not a foregone conclusion that people need to become depressed. If we can provide prevention and treatment to those people that are most at risk, we might be able to prevent depression, reduce the number of depressive episodes, or reduce their severity,” said Dr. Langenecker.

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60 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

61 (155.92575073242): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (678.06243896484): SELECT fid FROM jos_deeppockets WHERE id=294754466 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294754466 AND published='1' LIMIT 1

63 (560.99891662598): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (59.127807617188): select jos_twitters.link from jos_twitters where cat=10

65 (32.186508178711): select jos_facebook.link from jos_facebook where cat=10

66 (42.915344238281): select jos_google_plus.link from jos_google_plus where cat=10

67 (38.14697265625): select jos_linkedin.link from jos_linkedin where cat=10

68 (40.054321289062): SELECT fid FROM jos_deeppockets WHERE id=294754466 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294754466 AND published='1' LIMIT 1

69 (33.855438232422): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (421.04721069336): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754466 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (319.00405883789): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754466 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (50.783157348633): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (83.92333984375): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (92.983245849609): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (40.769577026367): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (82.015991210938): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754466 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (46.014785766602): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754466 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (103.95050048828): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (80.82389831543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

105 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

106 (49.829483032227): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754466 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (524.99771118164): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754466 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

109 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

110 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294754466 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (602.00691223145): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294754466 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (623.94142150879): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (353.09791564941): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

115 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

116 (68.187713623047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

117 (50.783157348633): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

118 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

119 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

120 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

121 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

122 (341.89224243164): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 21797.895431519): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (579.1187286377): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754466 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754466 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 8104.0859222412): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (125.88500976562): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (54.836273193359): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (82.015991210938): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (325.91819763184): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (71.048736572266): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (58.889389038086): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (474.92980957031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (328.06396484375): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (196.93374633789): SELECT name FROM jos_deeppockets WHERE id=212

138 (32.901763916016): SELECT name FROM jos_deeppockets WHERE id=212

139 (678.06243896484): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (650.16746520996): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

142 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

143 (!!!!! 9003.1623840332): TRUNCATE TABLE jos_trademed_module

144 (148.05793762207): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754466 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (87.02278137207): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754466 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 1134.8724365234): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (138.0443572998): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

149 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

150 (!!!!! 1395.9407806396): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

152 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

153 (39.100646972656): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754466 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754466 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (33.855438232422): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (51.975250244141): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (157.83309936523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

158 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754466 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754466 AND published='1' LIMIT 1

159 (45.061111450195): select jos_twitters.link from jos_twitters where cat=10

160 (72.956085205078): select jos_facebook.link from jos_facebook where cat=10

161 (37.908554077148): select jos_google_plus.link from jos_google_plus where cat=10

162 (32.186508178711): select jos_linkedin.link from jos_linkedin where cat=10

163 (308.99047851562): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1264.0953063965): insert into jos_banners_delta values (14615,'2025-06-24 03:38:42','216.73.216.120','view'),(14202,'2025-06-24 03:38:42','216.73.216.120','view'),(14203,'2025-06-24 03:38:42','216.73.216.120','view')

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