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Transarterial Chemoembolization Contrast Agent Approved by French National Agency for Liver Cancer

By MedImaging International staff writers
Posted on 07 Sep 2014

An imaging agent has been recently approved by the French National Agency for Medicines and Health Products (ANSM) for selective hepatic intra-arterial injection for visualization, localization, and vectorization during chemoembolization of tumors in adults with known, intermediate-stage hepatocellular carcinoma (HCC).

According to the World Health Organization (WHO; Geneva, Switzerland), HCC is the most common primary cancer and is the second biggest cause of death due to cancer worldwide.

“Guerbet [GBT; Villepinte, France] enters a new phase in obtaining this indication for Lipiodol in France for conventional transarterial chemoembolization [cTACE]. This procedure is carried out to deposit, in contact with the tumor, active substances which fight against the development of primary cancers in inoperable patients. The development of these minimally invasive, image-guided procedures is the new priority of Guerbet’s interventional radiology and theranostic division to enhance patient prognosis and quality of life,” commented Yves L’Epine, Guerbet’s CEO.

This approval follows that granted by the Japanese authorities in November 2013 for the treatment by conventional transarterial chemoembolization of HCC2 and the one granted by US authorities in April 2014 for the imaging of HCC3.

Worldwide, over 100 clinical studies have been published, including 12 randomized clinical trials on a total of over 10,000 patients presenting with an intermediate stage HCC. Recently, three international recommendations in Europe, the United States, and Japan established cTACE as the reference treatment for patients presenting with an intermediate-stage HCC. These consensual recommendations unanimously accredited the use of cTACE as the benchmark treatment for patients with known intermediate stage HCC. The recommendations reported that the life expectancy of inoperable HCC patients is increased, on average, by 16 to 20 months, due to cTACE. In recent clinical trials, using the most selective catheterization techniques, life expectancy was improved to 45 months. Consequently, treatment by cTACE use is constantly increasing on all continents, with an extra 500,000 patients being treated yearly.

Traditional cTACE is a minimally invasive procedure that consists of integrating Lipiodol Ultra-Fluid with an anticancer agent and injecting this mixture in the liver transarterially by targeted regional chemotherapy. Lipiodol Ultra-Fluid acts as a contrast agent, an eluent for cancer drugs, and a transient vascular embolization agent. cTACE was performed for the first time in Japan in 1982 and has since been successfully used in Asia, Europe, in the Middle East, Africa, and North America.

Lipiodol Ultra-Fluid (ethyl esters of iodized fatty acids of poppyseed oil) was originally developed for diagnostic radiology including the diagnosis of hepatic lesions, lymphography, and hysterosalpingography. Subsequently, the agent was used in interventional radiology for the treatment using standard cTACE of multinodular hepatocellular carcinoma, in which Lipiodol Ultra-Fluid is used as for its properties a contrast agent, vehicle for active substances, and embolization agent.

Guerbet is a pharmaceutical group fully focused on medical imaging worldwide. The company has a range of contrast agents for X-ray and magnetic resonance imaging (MRI) and for interventional radiology, along with a range of injectors and related medical equipment to provide improved diagnosis and treatment of patients.

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59 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

60 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

61 (95.129013061523): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (474.92980957031): SELECT fid FROM jos_deeppockets WHERE id=294754401 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294754401 AND published='1' LIMIT 1

63 (271.08192443848): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (42.915344238281): select jos_twitters.link from jos_twitters where cat=10

65 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

66 (41.961669921875): select jos_google_plus.link from jos_google_plus where cat=10

67 (29.802322387695): select jos_linkedin.link from jos_linkedin where cat=10

68 (40.054321289062): SELECT fid FROM jos_deeppockets WHERE id=294754401 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294754401 AND published='1' LIMIT 1

69 (42.915344238281): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (292.06275939941): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754401 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (284.91020202637): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754401 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (45.061111450195): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (54.836273193359): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (45.061111450195): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754401 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (61.03515625): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754401 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (40.054321289062): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

105 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

106 (55.074691772461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754401 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (43.869018554688): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294754401 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

109 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

110 (55.789947509766): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294754401 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (449.89585876465): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294754401 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (524.04403686523): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (315.90461730957): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

115 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

116 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

117 (36.001205444336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

118 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

119 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

120 (41.007995605469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

121 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

122 (309.94415283203): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754401 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754401 AND type='deeppockets_item' AND published='1' LIMIT 1

123 (!!!!! 7864.9520874023): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

124 (82.969665527344): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

125 (360.01205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

126 (102.04315185547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

127 (351.90582275391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

128 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

129 (214.81513977051): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

130 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

131 (190.01960754395): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

132 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

133 (427.9613494873): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

134 (313.04359436035): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

135 (194.07272338867): SELECT name FROM jos_deeppockets WHERE id=212

136 (34.093856811523): SELECT name FROM jos_deeppockets WHERE id=212

137 (556.94580078125): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

138 (583.88710021973): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

139 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

140 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

141 (277.04238891602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

142 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

143 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

144 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

145 (979.18510437012): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

146 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

147 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

148 (36.001205444336): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294754401 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294754401 AND type='deeppockets_item' AND published='1' LIMIT 1

149 (75.817108154297): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

150 (34.809112548828): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

151 (33.140182495117): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

152 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

153 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294754401 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294754401 AND published='1' LIMIT 1

154 (41.007995605469): select jos_twitters.link from jos_twitters where cat=10

155 (28.848648071289): select jos_facebook.link from jos_facebook where cat=10

156 (29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10

157 (31.948089599609): select jos_linkedin.link from jos_linkedin where cat=10

158 (240.08750915527): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

159 (!!!!! 1046.895980835): insert into jos_banners_delta values (14615,'2025-06-24 01:51:48','216.73.216.120','view'),(14202,'2025-06-24 01:51:48','216.73.216.120','view'),(14203,'2025-06-24 01:51:48','216.73.216.120','view')

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