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“Nanoconstructs” Designed to Enhance MRI Technology

By MedImaging International staff writers
Posted on 01 Jul 2014

Image: Silicon mesoporous particles (SiMPS), measure about 1,000 nm across contain thousands of much smaller particles of iron oxide. The SiMPs can be manipulated by magnets and gather at the site of tumors, where they can be heated to kill malignant tumors or trigger the release of drugs. The particles were created by an international team led by scientists at Rice University and Methodist Hospital Research Institute (Houston, TX, USA) (Photo courtesy of Rice University).

Submicrometer particles that contain even smaller particles of iron oxide could make magnetic resonance imaging (MRI) a much more effective way to detect and fight disease.

Medical researchers are creating composite particles that can be injected into patients and guided by magnetic fields. Once in position, the particles may be heated to kill malignant tissues or trigger the release of drugs at the site. The nanoscale composites, called “nanoconstructs,” should completely degrade and leave the body within a couple of days, the researchers reported.

The research, conducted by scientists from Rice University (Houston, TX, USA) and the Methodist Hospital Research Institute (TMHRI; Houston, TX, USA), led an international team of researchers and published their findings online April 22, 2014, in the journal Advanced Functional Materials. The team, led by Rice chemist Lon Wilson and TMHRI scientist Paolo Decuzzi, was searching for a way to overcome the challenges presented by iron oxide particles that are good at some things but not others, depending on their size. Iron oxide particles have many excellent features: They can be manipulated with magnets, provide excellent contrast under MRI scanning, generate heat when triggered, and degrade rapidly; however, they cannot do all that at once. The scientists needed a way to decouple the functions from their sizes.

The answer to the problem was to parcel thousands of iron oxide particles—with magnetic cores as small as 5 nm across—inside larger particles. The researchers created two such nanoconstructs, embedding iron oxide particles in silicon mesoporous particles (SiMPs) and discoidal polymeric nanoconstructs (DPNs). They knew from earlier research that submicron-sized SiMPs and DPNs naturally accumulate within the tumor’s blood vessels.

Iron oxide enhances the ability to position and hold the particles in place with magnets, according to lead author and Rice graduate student Ayrat Gizzatov. “They get attracted by the magnet, and that induces another dipole-dipole magnetic interaction among the particles and increases their interparticle communication mechanism,” he said.

Tests showed iron oxide particles made the nanoconstructs 10 times better than traditional contrast agents with what amounted to significantly lower doses of iron than used in current practice. The new research also showed that, as a general principle, confining MRI contrast agents (i.e., iron oxide) in geometric structures enhances their relaxivity—the feature that makes the agents appear in MRI images. (The shorter the relaxation time, the greater the contrast in the image.)

While the particles are too big to target specific proteins, Mr. Gizzatov noted that it might also be possible to engineer them with elements that will increase their accumulation in tumors.

Related Links:
Rice University
Methodist Hospital Research Institute

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63 (378.13186645508): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (52.928924560547): select jos_twitters.link from jos_twitters where cat=10

65 (31.948089599609): select jos_facebook.link from jos_facebook where cat=10

66 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

67 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

68 (50.067901611328): SELECT fid FROM jos_deeppockets WHERE id=294753309 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294753309 AND published='1' LIMIT 1

69 (32.901763916016): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (384.09233093262): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753309 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (319.9577331543): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753309 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (60.081481933594): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 3007.8887939453): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (90.837478637695): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (105.14259338379): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753309 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (33.140182495117): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753309 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (!!!!! 2808.0940246582): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 2074.0032196045): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (100.85105895996): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (62.942504882812): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (127.07710266113): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

105 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

106 (133.99124145508): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753309 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (677.82402038574): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753309 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 3201.961517334): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

109 (137.8059387207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

110 (84.877014160156): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294753309 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (670.9098815918): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294753309 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 3031.0153961182): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (794.88754272461): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (133.03756713867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

115 (108.95729064941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

116 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

117 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

118 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

119 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

120 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

121 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

122 (524.99771118164): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 44080.018997192): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (651.83639526367): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753309 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753309 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 13921.022415161): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 3525.972366333): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (56.982040405273): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (166.89300537109): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (280.85708618164): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (94.890594482422): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (325.91819763184): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (181.91337585449): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (82.015991210938): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (154.01840209961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 4951.9538879395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (480.89027404785): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (567.91305541992): SELECT name FROM jos_deeppockets WHERE id=212

138 (!!!!! 1216.1731719971): SELECT name FROM jos_deeppockets WHERE id=212

139 (!!!!! 1144.1707611084): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (572.20458984375): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

142 (226.02081298828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

143 (!!!!! 6129.0264129639): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 3661.8709564209): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753309 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (77.962875366211): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753309 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 1384.0198516846): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (346.89903259277): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 5115.9858703613): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

149 (!!!!! 1477.9567718506): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

150 (!!!!! 1464.1284942627): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (330.92498779297): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

152 (542.87910461426): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

153 (47.922134399414): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753309 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753309 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (32.186508178711): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (29.087066650391): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (29.802322387695): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

158 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753309 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753309 AND published='1' LIMIT 1

159 (164.03198242188): select jos_twitters.link from jos_twitters where cat=10

160 (!!!!! 1402.8549194336): select jos_facebook.link from jos_facebook where cat=10

161 (!!!!! 2050.8766174316): select jos_google_plus.link from jos_google_plus where cat=10

162 (461.81678771973): select jos_linkedin.link from jos_linkedin where cat=10

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