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MRI Brain Scans Able to Detect Early Parkinson’s Disease

By MedImaging International staff writers
Posted on 23 Jun 2014

Image: MRI scanning reveals see changes in the brain in early Parkinson’s (Photo courtesy of the University of Oxford).

British researchers have developed a simple and fast magnetic resonance imaging (MRI) technique that has potential for diagnosing Parkinson’s disease in the early stages.

The researchers demonstrated that their new MRI approach can identify individuals who have early-stage Parkinson’s disease with 85% accuracy, according to research published ahead of print June 11, 2014, in Neurology, the medical journal of the American Academy of Neurology.

“At the moment we have no way to predict who is at risk of Parkinson’s disease in the vast majority of cases,” noted Dr. Clare Mackay of the department of psychiatry at Oxford University (UK), one of the joint lead researchers. “We are excited that this MRI technique might prove to be a good marker for the earliest signs of Parkinson’s. The results are very promising.”

Claire Bale, research communications manager at Parkinson’s UK, which funded the research, clarified, “This new research takes us one step closer to diagnosing Parkinson’s at a much earlier stage—one of the biggest challenges facing research into the condition. By using a new, simple scanning technique, the team at Oxford University have been able to study levels of activity in the brain which may suggest that Parkinson’s is present. One person every hour is diagnosed with Parkinson’s in the UK, and we hope that the researchers are able to continue to refine their test so that it can one day be part of clinical practice.”

Parkinson’s disease is characterized by tremor, slow movement, and stiff and inflexible muscles. There is currently no cure for the disease, although there are treatments that can reduce symptoms and maintain quality of life for as long as possible.

Parkinson’s disease is caused by the progressive loss of a particular set of nerve cells in the brain, but this damage to nerve cells will have been going on for a long time before symptoms become apparent. If treatments are to be developed that can slow or block the progression of the disease before it affects people significantly, according to the researchers, we need methods to be able to identify people at risk before symptoms take hold.

Conventional MRI cannot detect early signs of Parkinson’s, so the Oxford researchers used an MRI technique, called resting-state fMRI, in which people are simply required to stay still in the scanner. They used the MRI data to look at the “connectivity” in the basal ganglia—the region of the brain known to be involved in Parkinson’s disease.

The investigators compared 19 people with early-stage Parkinson’s disease while not on medication with 19 healthy people, matched for age and gender. They found that the Parkinson’s patients had much lower connectivity in the basal ganglia. They were able to define a cut-off or threshold level of connectivity. Falling below this level was able to predict who had Parkinson's disease with 100% sensitivity and 89.5% specificity.

Dr. Mackay explained,” MRI approach showed a very strong difference in connectivity between those who had Parkinson’s disease and those that did not. So much so, that we wondered if it was too good to be true and carried out a validation test in a second group of patients. We got a similar result the second time.”

The scientists applied their MRI test to a second group of 13 early-stage Parkinson’s patients as a validation of the approach. They correctly identified 11 out of the 13 patients (85% accuracy). “We think that our MRI test will be relevant for diagnosis of Parkinson’s,” remarked joint lead researcher Dr. Michele Hu of the Nuffield department of clinical neurosciences at Oxford University and the Oxford University Hospitals NHS [National Health Service] Trust. “We tested it in people with early-stage Parkinson’s. But because it is so sensitive in these patients, we hope it will be able to predict who is at risk of disease before any symptoms have developed. However, this is something that we still have to show in further research.”

To see if this is indeed true, the Oxford University researchers are now carrying out further research of their MRI approach with individuals who are at increased risk of Parkinson’s.

Related Links:
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59 (!!!!! 1244.068145752): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

60 (315.90461730957): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

61 (!!!!! 2089.0235900879): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (730.03768920898): SELECT fid FROM jos_deeppockets WHERE id=294753152 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294753152 AND published='1' LIMIT 1

63 (540.97175598145): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (551.93901062012): select jos_twitters.link from jos_twitters where cat=10

65 (443.93539428711): select jos_facebook.link from jos_facebook where cat=10

66 (231.02760314941): select jos_google_plus.link from jos_google_plus where cat=10

67 (75.101852416992): select jos_linkedin.link from jos_linkedin where cat=10

68 (!!!!! 2147.912979126): SELECT fid FROM jos_deeppockets WHERE id=294753152 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294753152 AND published='1' LIMIT 1

69 (49.114227294922): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (186.92016601562): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753152 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (138.99803161621): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753152 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (54.121017456055): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (72.002410888672): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (488.0428314209): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753152 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (36.001205444336): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753152 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (!!!!! 2090.9309387207): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (590.08598327637): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (53.167343139648): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (197.17216491699): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (296.83113098145): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (142.81272888184): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (302.07633972168): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (777.9598236084): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

105 (238.89541625977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

106 (349.99847412109): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753152 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (84.161758422852): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753152 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (732.1834564209): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

109 (190.01960754395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

110 (239.84909057617): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294753152 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (577.92663574219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294753152 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (722.88513183594): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (540.97175598145): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (247.00164794922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

115 (115.87142944336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

116 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

117 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

118 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

119 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

120 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

121 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

122 (394.10591125488): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 66197.872161865): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (685.9302520752): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753152 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753152 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 32836.9140625): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 19888.162612915): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (126.83868408203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (54.121017456055): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (90.122222900391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (47.922134399414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (525.95138549805): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (!!!!! 2565.860748291): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (138.0443572998): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (579.833984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (463.00888061523): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (231.98127746582): SELECT name FROM jos_deeppockets WHERE id=212

138 (!!!!! 3391.9811248779): SELECT name FROM jos_deeppockets WHERE id=212

139 (972.03254699707): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (787.97340393066): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (!!!!! 5832.1952819824): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

142 (119.92454528809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

143 (!!!!! 18867.969512939): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 4007.10105896): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753152 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (814.91470336914): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294753152 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (535.96496582031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (116.82510375977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (94.890594482422): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

149 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

150 (!!!!! 1554.9659729004): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (783.92028808594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

152 (96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

153 (616.07360839844): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294753152 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294753152 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (53.882598876953): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (44.822692871094): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (!!!!! 2678.8711547852): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (186.92016601562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

158 (123.02398681641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294753152 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294753152 AND published='1' LIMIT 1

159 (63.896179199219): select jos_twitters.link from jos_twitters where cat=10

160 (45.061111450195): select jos_facebook.link from jos_facebook where cat=10

161 (41.007995605469): select jos_google_plus.link from jos_google_plus where cat=10

162 (59.843063354492): select jos_linkedin.link from jos_linkedin where cat=10

163 (601.05323791504): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1400.9475708008): insert into jos_banners_delta values (14615,'2025-06-24 00:44:40','216.73.216.120','view'),(14202,'2025-06-24 00:44:40','216.73.216.120','view'),(14203,'2025-06-24 00:44:40','216.73.216.120','view')

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