Download Mobile App

Video Library

Featured Links

Medical Imaging Equipment
Trademed.com is our new marketplace where you can buy and sell Imaging equipment.

Complete Response Rates Seen in Refractory Melanoma Patients

By MedImaging International staff writers
Posted on 04 Jun 2014

New research examines complete response and induced immune response in melanoma patients that may generate a “bystander effect.”

Provectus Biopharmaceuticals, Inc. (Knoxville, TN, USA), a development-stage oncology and dermatology biopharmaceutical company, reported that data on its investigational agent PV-10 for intralesional (IL) treatment of locally advanced cutaneous melanoma was featured in two presentations, on June 2, 2014, during the American Society of Clinical Oncology (ASCO) annual meeting held in Chicago (IL USA). These presentations show that IL PV-10 can potentially offer cancer patients control of their cutaneous symptoms and provoke a systemic antitumor immune response that may lead to response of uninjected lesions (the “bystander effect” that has been observed in earlier clinical studies of PV-10).

The first highlighted poster, presented by Sanjiv S. Agarwala, MD, of the St. Luke’s Cancer Center (Bethlehem, PA, USA), was entitled “Efficacy of intralesional rose bengal in patients receiving injection in all existing melanoma in phase II study PV-10-MM-02.” The second highlighted poster, presented by Amod Sarnaik, MD, from Moffitt Cancer Center (Tampa, FL, USA) was titled “Assessment of immune and clinical efficacy after intralesional PV-10 in injected and uninjected metastatic melanoma lesions.”

Dr. Agarwala and coauthors from seven prominent melanoma centers in the United States and Australia studied the safety and efficacy of IL PV-10 in an 80-patient international, multicenter, single arm phase 2 trial. A subgroup analysis of 28 patients with all existing melanoma lesions injected and an additional 26 patients with only one to two uninjected bystander lesions showed that these patients experienced an exceptionally high rate of response. The best overall response rate (BORR) in the 28-patient “all treated” subgroup was 71% (confidence interval (CI) of 51%–87%), with 50% complete response (CI 31%–69%). Among the 54 patients in both of these subgroups (i.e., patients who had all of their disease monitored in the study), complete response (CR) was achieved in 232 of 363 injected lesions (64% CR). Furthermore, CR was achieved in 121 lesions after a single injection of PV-10; 84 lesions required two injections to achieve CR; 22 lesions required three injections; and five lesions required all four allowed four injections.

Dr. Agarwala said, “The high rate of symptom control in refractory patients with disease limited to the skin, manifested in CR of all monitored disease after minimal intervention, is the basis for a pending breakthrough therapy designation application for PV-10. Although the primary ablative effect is responsible for CR in injected lesions, durability of response and bystander response observed in this study implicate an immunologic mechanism of action secondary to ablation.”

In the Moffitt poster, Dr. Sarnaik and coauthors reported interim results of a pilot clinical trial designed to investigate the immunologic basis of this bystander response. In this single institution translational study, a target lesion and a bystander were biopsied prior to treatment of the target lesion with PV-10. Both lesions were then resected within 7-14 days of target lesion injection and compared to pre-treatment biopsies. Peripheral blood was also collected pretreatment, at the time of resection, and at day 28. The researchers note “treatment with IL PV-10 led to pCR (pathologic complete response) in the post-treatment biopsies of both PV-10 injected and uninjected study lesions in four of the eight patients, and all eight exhibited at least partial regression of the injected lesion.” The abstract continues, “Six of the eight patients had metastatic disease refractory to previous ipilimumab, anti-PD-1 and/or vemurafenib therapy.” Based on T cells isolated from the peripheral blood of the patients, the authors conclude that, “IL PV-10 treatment can lead to systemic antimelanoma immunity and pCR in injected and uninjected lesions including treatment-refractory tumors.”

Craig Dees, PhD, CEO of Provectus, said, “Taken together, these posters indicate that, with minimal intervention, PV-10 can rapidly eliminate refractory cutaneous melanoma lesions. IL PV-10 is also associated with an increase in important circulating immune cells specific to the injected lesion, potentially explaining the high rate of bystander lesion regression seen in our clinical trials of PV-10 in locally advanced melanoma patients. The duration of response and the bystander response reported in the phase 2 trial was beyond the scope of simple tumor ablation. In 2013, Moffitt researchers published data from mice showing increased antitumor T cell responses, and this year at ASCO they have bridged that nonclinical finding to the same phenomenon in man. It is unprecedented for a small molecule ablative agent to have this kind of immune system activity detectable in peripheral blood of patients. The one-two punch from PV-10 [rapidly reducing tumor burden and producing immune system stimulation] is presumably the underlying driver of these durable complete responses in patients with cutaneous melanoma.”

Provectus submitted an application in March 2014 to the US Food and Drug Administration (FDA) for breakthrough therapy designation for PV-10 based on the results from its phase 2 clinical study related to metastatic melanoma and is researching efficacy of PV-10 for other indications, including liver and breast cancers.

Provectus Biopharmaceuticals specializes in developing oncology and dermatology therapies. Its novel oncology drug PV-10, (a formulation of the small molecule ablative agent rose bengal disodium) is designed to selectively target and destroy cancer cells without harming surrounding healthy tissue, significantly reducing potential for systemic side effects. Its oncology focus is on melanoma, breast cancer and cancers of the liver. The company has received orphan drug designations from the FDA for its melanoma and hepatocellular carcinoma indications. Its dermatological drug PH-10 also targets abnormal or diseased cells, with the current focus on psoriasis and atopic dermatitis. Provectus has recently completed phase 2 trials of PV-10 as a therapy for metastatic melanoma, and of PH-10 as a topical treatment for atopic dermatitis and psoriasis.

Provectus Biopharmaceuticals
St. Luke’s Cancer Center
Moffitt Cancer Center

Related Links:

Visit expo >

Gold Member

Ultrasound System

FUTUS LE

Gold Member

Electrode Solution and Skin Prep

Signaspray

Ferromagnetic Hand-Held Detector

FerrAlert Target Scanner

Afterloader For Brachytherapy

Flexitron

Latest MRI News

Channels

Radiography

view channel

Image: A 4mm square diamond radiation detector (Photo courtesy of Orbray)

World's Largest Class Single Crystal Diamond Radiation Detector Opens New Possibilities for Diagnostic Imaging

Diamonds possess ideal physical properties for radiation detection, such as exceptional thermal and chemical stability along with a quick response time. Made of carbon with an atomic number of six, diamonds... Read more

Image: The AI-powered FFR assessment is comparable to conventional assessment (Photo courtesy of 123RF)

MRI

view channel

Image: An AI tool has shown tremendous promise for predicting relapse of pediatric brain cancer (Photo courtesy of 123RF)

AI Tool Predicts Relapse of Pediatric Brain Cancer from Brain MRI Scans

Many pediatric gliomas are treatable with surgery alone, but relapses can be catastrophic. Predicting which patients are at risk for recurrence remains challenging, leading to frequent follow-ups with... Read more

AI Tool Tracks Effectiveness of Multiple Sclerosis Treatments Using Brain MRI Scans

Multiple sclerosis (MS) is a condition in which the immune system attacks the brain and spinal cord, leading to impairments in movement, sensation, and cognition. Magnetic Resonance Imaging (MRI) markers... Read more

Ultra-Powerful MRI Scans Enable Life-Changing Surgery in Treatment-Resistant Epileptic Patients

Approximately 360,000 individuals in the UK suffer from focal epilepsy, a condition in which seizures spread from one part of the brain. Around a third of these patients experience persistent seizures... Read more

Image: The automated MRI processing and machine learning software features a noninvasive biomarker technique (Photo courtesy of University of Florida)

AI-Powered MRI Technology Improves Parkinson’s Diagnoses

Current research shows that the accuracy of diagnosing Parkinson’s disease typically ranges from 55% to 78% within the first five years of assessment. This is partly due to the similarities shared by Parkinson’s... Read more

Ultrasound

view channel

AI-Powered Lung Ultrasound Outperforms Human Experts in Tuberculosis Diagnosis

Despite global declines in tuberculosis (TB) rates in previous years, the incidence of TB rose by 4.6% from 2020 to 2023. Early screening and rapid diagnosis are essential elements of the World Health... Read more

Image: Researchers are using AI to analyze images from a common heart test to identify signs of valve disease (Photo courtesy of 123RF)

AI Identifies Heart Valve Disease from Common Imaging Test

Tricuspid regurgitation is a condition where the heart's tricuspid valve does not close completely during contraction, leading to backward blood flow, which can result in heart failure. A new artificial... Read more

Image: Diagram of ULM processing (Photo courtesy of Cyborg and Bionic Systems)

Novel Imaging Method Enables Early Diagnosis and Treatment Monitoring of Type 2 Diabetes

Type 2 diabetes is recognized as an autoimmune inflammatory disease, where chronic inflammation leads to alterations in pancreatic islet microvasculature, a key factor in β-cell dysfunction.... Read more

Image: Artist’s impression of the new ultrasound technique, called nonlinear sound sheet microscopy (Photo courtesy of Maayan Harel/Maresca Lab)

Ultrasound-Based Microscopy Technique to Help Diagnose Small Vessel Diseases

Clinical ultrasound, commonly used in pregnancy scans, provides real-time images of body structures. It is one of the most widely used imaging techniques in medicine, but until recently, it had little... Read more

Nuclear Medicine

view channel

Image: In vivo imaging of U-87 MG xenograft model with varying mass doses of 89Zr-labeled KLG-3 or isotype control (Photo courtesy of L Gajecki et al.; doi.org/10.2967/jnumed.124.268762)

Novel Radiolabeled Antibody Improves Diagnosis and Treatment of Solid Tumors

Interleukin-13 receptor α-2 (IL13Rα2) is a cell surface receptor commonly found in solid tumors such as glioblastoma, melanoma, and breast cancer. It is minimally expressed in normal tissues, making it... Read more

Novel PET Imaging Approach Offers Never-Before-Seen View of Neuroinflammation

COX-2, an enzyme that plays a key role in brain inflammation, can be significantly upregulated by inflammatory stimuli and neuroexcitation. Researchers suggest that COX-2 density in the brain could serve... Read more

Novel Radiotracer Identifies Biomarker for Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC), which represents 15-20% of all breast cancer cases, is one of the most aggressive subtypes, with a five-year survival rate of about 40%. Due to its significant heterogeneity... Read more

Image: A repurposed ALS drug has become an imaging probe to help diagnose neurodegeneration (Photo courtesy of St. Jude Children’s Research Hospital)

Innovative PET Imaging Technique to Help Diagnose Neurodegeneration

Neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease, are often diagnosed only after physical symptoms appear, by which time treatment may no longer be effective.... Read more

General/Advanced Imaging

view channel

Image: The LungVision system has received regulatory approval from the TGA in Australia (Photo courtesy of Body Vision Medical)

AI-Powered Imaging System Improves Lung Cancer Diagnosis

Given the need to detect lung cancer at earlier stages, there is an increasing need for a definitive diagnostic pathway for patients with suspicious pulmonary nodules. However, obtaining tissue samples... Read more

Image: The multimodal multitask foundation model enhances lung cancer screening (Photo courtesy of 123RF)

AI Model Significantly Enhances Low-Dose CT Capabilities

Lung cancer remains one of the most challenging diseases, making early diagnosis vital for effective treatment. Fortunately, advancements in artificial intelligence (AI) are revolutionizing lung cancer... Read more

Image: Axial noncontrast chest CT lung window images of three different sample patches shown in each row (Photo courtesy of Radiology: Cardiothoracic Imaging)

Ultra-Low Dose CT Aids Pneumonia Diagnosis in Immunocompromised Patients

Lung infections can be life-threatening for patients with weakened immune systems, making timely diagnosis crucial. While CT scans are considered the gold standard for detecting pneumonia, repeated scans... Read more

Image: Histologically confirmed lung cancer cases detected at immediate referral after baseline scan or 3-month short-term follow-up (Photo courtesy of DOI:10.1016/j.ejca.2025.115324)

AI Reduces CT Lung Cancer Screening Workload by Almost 80%

Lung cancer impacts over 48,000 individuals in the UK annually, and early detection is key to improving survival rates. The UK Lung Cancer Screening (UKLS) trial has already shown that low-dose CT (LDCT)... Read more

Imaging IT

view channel

New Google Cloud Medical Imaging Suite Makes Imaging Healthcare Data More Accessible

Medical imaging is a critical tool used to diagnose patients, and there are billions of medical images scanned globally each year. Imaging data accounts for about 90% of all healthcare data1 and, until... Read more

Global AI in Medical Diagnostics Market to Be Driven by Demand for Image Recognition in Radiology

The global artificial intelligence (AI) in medical diagnostics market is expanding with early disease detection being one of its key applications and image recognition becoming a compelling consumer proposition... Read more

AI-Based Mammography Triage Software Helps Dramatically Improve Interpretation Process

An artificial intelligence (AI)-based mammography triage software is helping dramatically improve the interpretation process for healthcare providers. In a new study, researchers at the Scripps Green... Read more

Artificial Intelligence (AI) Program Accurately Predicts Lung Cancer Risk from CT Images

An artificial intelligence (AI) program accurately predicts the risk that lung nodules detected on screening CT will become cancerous, according to a study published in the journal Radiology.... Read more

Industry News

view channel

GE HealthCare and NVIDIA Collaboration to Reimagine Diagnostic Imaging

GE HealthCare (Chicago, IL, USA) has entered into a collaboration with NVIDIA (Santa Clara, CA, USA), expanding the existing relationship between the two companies to focus on pioneering innovation in... Read more

Image: The patient-specific 3D-printed phantoms usher in a new era for medical imaging research (Photo courtesy of Siemens Healthineers)

Patient-Specific 3D-Printed Phantoms Transform CT Imaging

New research has highlighted how anatomically precise, patient-specific 3D-printed phantoms are proving to be scalable, cost-effective, and efficient tools in the development of new CT scan algorithms... Read more

Siemens and Sectra Collaborate on Enhancing Radiology Workflows

Siemens Healthineers (Forchheim, Germany) and Sectra (Linköping, Sweden) have entered into a collaboration aimed at enhancing radiologists' diagnostic capabilities and, in turn, improving patient care... Read more

Image: Virtual colonoscopy (CT colonography) is an approved option for screening for colorectal cancer in the US (Photo courtesy of Shtutterstock)

Bracco Diagnostics and ColoWatch Partner to Expand Availability CRC Screening Tests Using Virtual Colonoscopy

Over the last 25 years, virtual colonoscopy has been proven to be a highly accurate, safe, convenient, and cost-effective method of colorectal cancer (CRC) prevention and screening. It can reliably find... Read more

1 (56.028366088867): SET sql_mode = 'MYSQL40'

2 (49.829483032227): SELECT folder, element, published, params FROM jos_mambots WHERE published >= 1 AND access <= 0 AND folder = 'system' ORDER BY ordering

3 (425.10032653809): SELECT template FROM jos_templates_menu WHERE client_id = 0 AND ( menuid = 0 OR menuid = 294752844 ) ORDER BY menuid DESC LIMIT 1

4 (297.06954956055): DELETE FROM jos_session WHERE time < 1755448370 AND guest = 1 AND userid = 0

5 (48.160552978516): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

6 (31.948089599609): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

7 (30.040740966797): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

8 (446.08116149902): SELECT * FROM jos_menu WHERE id = 294752844

9 (629.90188598633): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294752844 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

10 (568.86672973633): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294752844 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

11 (86.069107055664): SELECT dp.*, ch.title as channel, ch.name as channel_name, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 #AND dp.cat=10 AND dp.id=294752844 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

12 (!!!!! 1104.1164398193): SELECT * FROM jos_deeppockets WHERE 1=1 AND cat=10 AND type='deeppockets_item' AND published='1' AND (id<>294752844) AND (fid=212) ORDER BY id DESC, `created` DESC LIMIT 0,16

13 (163.07830810547): SELECT * FROM jos_deeppockets WHERE 1=1 AND cat=10 AND type='deeppockets_item' AND published='1' AND (id<>294752844) AND (fid=212) ORDER BY id DESC, `created` DESC LIMIT 0,16

14 (!!!!! 3138.0653381348): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_item.fid=212 and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294752844 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

15 (!!!!! 3219.1276550293): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_item.fid=212 and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294752844 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

16 (!!!!! 1416.9216156006): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294752844 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

17 (!!!!! 1393.0797576904): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='P' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) AND (jos_number.channelID=294752844 OR jos_number.channelID=0) ORDER BY RAND() DESC LIMIT 3

18 (98.943710327148): SELECT name,id,title FROM jos_deeppockets WHERE id=212 LIMIT 1

19 (40.054321289062): SELECT name,id,title FROM jos_deeppockets WHERE id=212 LIMIT 1

20 (490.90385437012): SELECT dp.*, ch.title as channel, ch.name as channel_name FROM jos_deeppockets as dp LEFT JOIN jos_deeppockets as ch ON ch.id = dp.fid WHERE 1=1 AND dp.id=294752843 AND dp.type='deeppockets_item' AND dp.published='1' LIMIT 1

21 (389.09912109375): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752843 AND type='deeppockets_item' AND published='1' LIMIT 1

22 (466.10832214355): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752843 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

23 (478.98292541504): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752843 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

24 (77.962875366211): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752843 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

25 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752843 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

26 (476.12190246582): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752844 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

27 (535.96496582031): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752844 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

28 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752843 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

29 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752843 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

30 (403.88107299805): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752843 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

31 (514.98413085938): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752843 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

32 (268.22090148926): SELECT conference_items.channel_id, conference_items.tracking_code FROM conference_items LEFT JOIN conference_groups ON conference_groups.id = conference_items.group_id LEFT JOIN jos_deeppockets ON jos_deeppockets.id = conference_items.channel_id LEFT JOIN jos_journal ON jos_journal.cat = jos_deeppockets.cat AND jos_journal.real = 1 AND jos_journal.directory IS NOT NULL WHERE 1 = 1 ORDER BY conference_items.id

33 (478.02925109863): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294752843 LIMIT 1

34 (83.208084106445): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294752843 LIMIT 1

35 (299.93057250977): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294752843 LIMIT 1

36 (54.121017456055): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294752843 LIMIT 1

37 (57.93571472168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294752843 LIMIT 1

38 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294752843 LIMIT 1

39 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294752843 LIMIT 1

40 (44.107437133789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294752843 LIMIT 1

41 (!!!!! 1095.0565338135): SELECT id, title, module, position, content, showtitle, params FROM jos_modules AS m INNER JOIN jos_modules_menu AS mm ON mm.moduleid = m.id WHERE m.published = 1 AND m.access <= 0 AND m.client_id != 1 AND ( mm.menuid = 0 OR mm.menuid = 294752844 ) ORDER BY ordering

42 (!!!!! 1513.9579772949): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

43 (88.930130004883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

44 (103.95050048828): SELECT * FROM jos_bannersmanager_banner WHERE `groupid` = 98 AND `site_id` = 10 AND `published` = 1

45 (50.783157348633): SELECT * FROM jos_bannersmanager_banner WHERE `groupid` = 99 AND `site_id` = 10 AND `published` = 1

46 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

47 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

48 (147.10426330566): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

49 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

50 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

51 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

52 (124.93133544922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

53 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

54 (502.8247833252): SELECT name FROM jos_deeppockets WHERE id=294752844 LIMIT 1

55 (404.11949157715): SELECT name FROM jos_deeppockets_archive WHERE id=294752844 LIMIT 1

56 (92.983245849609): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'

57 (101.08947753906): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752844 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

58 (705.00373840332): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752844 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (!!!!! 1307.0106506348): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

60 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

61 (174.04556274414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

62 (90.837478637695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

63 (179.05235290527): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (784.87396240234): SELECT fid FROM jos_deeppockets WHERE id=294752844 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294752844 AND published='1' LIMIT 1

65 (79.154968261719): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

66 (88.930130004883): select jos_twitters.link from jos_twitters where cat=10

67 (49.114227294922): select jos_facebook.link from jos_facebook where cat=10

68 (51.021575927734): select jos_google_plus.link from jos_google_plus where cat=10

69 (49.114227294922): select jos_linkedin.link from jos_linkedin where cat=10

70 (77.009201049805): SELECT fid FROM jos_deeppockets WHERE id=294752844 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294752844 AND published='1' LIMIT 1

71 (57.93571472168): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

72 (623.94142150879): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752844 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (443.93539428711): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752844 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (73.909759521484): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (74.148178100586): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (86.069107055664): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752844 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (41.961669921875): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752844 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (47.922134399414): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (!!!!! 1790.0466918945): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (80.82389831543): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (108.95729064941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

107 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

108 (!!!!! 1971.0063934326): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752844 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (741.95861816406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752844 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (900.9838104248): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

111 (125.88500976562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

112 (!!!!! 2778.0532836914): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752844 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (805.85479736328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752844 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (120.16296386719): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752843 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (607.01370239258): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752843 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (!!!!! 1267.9100036621): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (707.86476135254): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (416.04042053223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

119 (!!!!! 1007.080078125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

120 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

121 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

122 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

123 (467.77725219727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

124 (185.96649169922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

125 (148.05793762207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

126 (392.91381835938): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

127 (!!!!! 54809.093475342): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

128 (751.01852416992): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752844 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752844 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 22578.001022339): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (72.956085205078): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (96.08268737793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

132 (56.028366088867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

133 (102.99682617188): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

134 (47.922134399414): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

135 (427.9613494873): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

136 (496.14906311035): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

137 (53.882598876953): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

138 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

139 (581.02607727051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (334.9781036377): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (43.869018554688): SELECT name FROM jos_deeppockets WHERE id=212

142 (42.915344238281): SELECT name FROM jos_deeppockets WHERE id=212

143 (667.09518432617): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (545.02487182617): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

145 (!!!!! 4884.0045928955): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

146 (154.97207641602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

147 (!!!!! 14036.893844604): TRUNCATE TABLE jos_trademed_module

148 (!!!!! 2969.0265655518): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752844 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (117.06352233887): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752844 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

150 (!!!!! 1013.9942169189): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

152 (108.95729064941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

153 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

154 (!!!!! 1366.8537139893): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

155 (!!!!! 2429.0084838867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

156 (118.01719665527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

157 (57.93571472168): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752844 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752844 AND type='deeppockets_item' AND published='1' LIMIT 1

158 (36.001205444336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

159 (32.901763916016): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

160 (36.001205444336): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

161 (715.01731872559): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

162 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752844 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752844 AND published='1' LIMIT 1

163 (89.168548583984): select jos_twitters.link from jos_twitters where cat=10

164 (43.869018554688): select jos_facebook.link from jos_facebook where cat=10

165 (42.915344238281): select jos_google_plus.link from jos_google_plus where cat=10

166 (43.153762817383): select jos_linkedin.link from jos_linkedin where cat=10

Click for LinkXpress Reader Inquiry Service
Enter code to receive information:

Where I can find code?

LinkXpress

Download Mobile App

Video Library

Featured Links

Complete Response Rates Seen in Refractory Melanoma Patients

Latest MRI News

Channels

MedImaging

Channels

Features

Partner Sites

Archive: