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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

“Fastener” Molecules Enhance MRI Contrast Agents

By MedImaging International staff writers
Posted on 04 Jun 2014

Image: Dr. Kong and others demonstrated that their fastener molecule readily inserted itself into the membrane of pre-made liposomes. Gadolinium stably associated with the modified nanoparticles in solution, and experiments in animal models showed that these nanoparticles produced clear diagnostic images (Photo courtesy of Janet Sinn-Hanlon, DesignGroup@VetMed, University of Illinois).

Biomedical scientists have increased the effectiveness of specific contrast agents that are frequently used for imaging blood vessels and internal bleeding by linking them with nanoparticles. The contrast agent being used is packaged inside or bonded to the surface of microscopic particles, which can be designed to target specific parts of the body or prolong the agent’s activity.

When associate professor of chemical and biomolecular engineering Dr. Hyunjoon Kong, graduate student Cartney Smith, and colleagues from the Institute for Genomic Biology, University of Illinois at Urbana-Champaign (USA) set out to improve magnetic resonance imaging (MRI) technology, they turned to current contrast agent technology inside out.

When clinicians perform an MRI scan, they administer a contrast agent: a compound that, when injected into the bloodstream or ingested by the patient just before the MRI, improves structure or organ clarity in the resulting image. One typical class of contrast agent, frequently used for imaging of blood vessels and internal bleeding, contains gadolinium, a rare-earth metal.

Recently, biomedical researchers have discovered ways to increase the effectiveness of certain contrast agents by associating them with nanoparticles. The contrast agent being used is packaged inside or bonded to the surface of microscopic particles, which can be designed to target certain regions of the body or prolong the agent’s activity. They are now examining the multipurpose use of nanoparticles. If particles could be loaded with several types of contrast agents or dyes instead of one, or a contrast agent along with another type of diagnostic aid or a medication, clinicians could more effectively test for and treat disorders, and limit the number of injections received by patients.

Similar to children sharing a new plaything, although, compounds packed together into a nanoparticle cannot always play well together. For instance, contrast agents may bind to other chemicals, reducing their effectiveness. Furthermore, when contrast agents are enclosed inside a nanoparticle, they may not work as well. Efforts to attach agents to the outer surface of nanoparticles by covalent formation are also challenging, as they can negatively affect the nanoparticle activity or the compounds that they carry.

Drs. Kong, Smith and colleagues attacked these challenges by using interactions between naturally occurring biomolecules as a guide. Many types of proteins are strongly attached to cell membranes not by covalent bonds, but by the sum of multiple weaker forces—the attraction of positive and negative charges, and the tendency of nonpolar (oil-like) compounds to seek each other and avoid water.

The group theorized that the same types of forces could be used to attach a contrast agent to the surface of a type of nanoparticle called a liposome, which resembles a little piece of cell membrane in the shape of a tiny bubble. The researchers designed a “fastener” molecule, DTPA-chitosan-g-C18, that is charged, attracting it to the liposome and binding it to the contrast agent gadolinium. A nonpolar region anchors it to the liposome membrane.

In a series of experiments reported October 2014 American Cancer Society’s journal ACS Nano article, Dr. Kong and coworkers demonstrated that their fastener molecule easily inserted itself into the membrane of pre-made liposomes. Gadolinium stably associated with the engineered nanoparticles in solution, and research in animal models revealed that these nanoparticles generated well-defined diagnostic images.

“The strategy works like Velcro on a molecular level to adhere functional units to the outer leaflet of a liposome,” said Dr. Smith, who was first author on the study. “This work represents a new material design strategy that is scalable and easily implemented. The development of improved contrast agents has the potential to directly impact patients’ lives by detecting damaged blood vessels.”

One of the difficulties of working with liposomes is their tendency to degrade inside the body. When the fastener-loaded liposomes degraded, some of the efficacy of the gadolinium was lost. In a second study published April 8, 2014, in the journal Langmuir, Drs. Kong and Smith developed a process for chemically cross-linking the components of the nanoparticle that prolonged the life of the nanoparticles in biologic environments.

Related Links:
Institute for Genomic Biology, University of Illinois at Urbana-Champaign

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57 (!!!!! 1195.1923370361): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

58 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

59 (120.16296386719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

60 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

61 (82.015991210938): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (629.90188598633): SELECT fid FROM jos_deeppockets WHERE id=294752825 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294752825 AND published='1' LIMIT 1

63 (396.0132598877): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (74.863433837891): select jos_twitters.link from jos_twitters where cat=10

65 (36.001205444336): select jos_facebook.link from jos_facebook where cat=10

66 (34.093856811523): select jos_google_plus.link from jos_google_plus where cat=10

67 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

68 (46.014785766602): SELECT fid FROM jos_deeppockets WHERE id=294752825 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294752825 AND published='1' LIMIT 1

69 (31.948089599609): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (292.06275939941): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752825 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (225.06713867188): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752825 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (44.822692871094): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (57.93571472168): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (55.074691772461): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (56.028366088867): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752825 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (31.948089599609): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752825 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (36.001205444336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

105 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

106 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752825 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (45.7763671875): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752825 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

109 (44.822692871094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

110 (49.114227294922): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752825 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (508.06999206543): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294752825 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (554.08477783203): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (314.95094299316): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

115 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

116 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

117 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

118 (42.200088500977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

119 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

120 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

121 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

122 (268.93615722656): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 19511.938095093): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (485.89706420898): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752825 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752825 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 7692.0986175537): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (70.810317993164): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (335.9317779541): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (205.03997802734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (179.05235290527): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (175.95291137695): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (33.140182495117): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (497.10273742676): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (319.9577331543): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (195.98007202148): SELECT name FROM jos_deeppockets WHERE id=212

138 (34.093856811523): SELECT name FROM jos_deeppockets WHERE id=212

139 (595.0927734375): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (466.10832214355): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

142 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

143 (!!!!! 8733.9878082275): TRUNCATE TABLE jos_trademed_module

144 (105.85784912109): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752825 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (55.074691772461): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294752825 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (823.02093505859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

149 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

150 (!!!!! 1099.1096496582): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

152 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

153 (40.054321289062): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294752825 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294752825 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (35.04753112793): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (40.054321289062): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (144.00482177734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

158 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294752825 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294752825 AND published='1' LIMIT 1

159 (133.99124145508): select jos_twitters.link from jos_twitters where cat=10

160 (39.815902709961): select jos_facebook.link from jos_facebook where cat=10

161 (29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10

162 (25.98762512207): select jos_linkedin.link from jos_linkedin where cat=10

163 (272.03559875488): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (919.10362243652): insert into jos_banners_delta values (14615,'2025-06-24 01:06:12','216.73.216.120','view'),(14202,'2025-06-24 01:06:12','216.73.216.120','view'),(14203,'2025-06-24 01:06:12','216.73.216.120','view')

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