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MRI Identifies Parkinson’s in Patients at Risk of Dementia

By MedImaging International staff writers
Posted on 26 Mar 2014

According to new research out of Canada, it may now be possible to identify which first-stage Parkinson’s disease (PD) patients who will go on to develop dementia.

The study was conducted at the Institut Universitaire de Geriatrie de Montreal (Montreal, QC, Canada) by Dr. Oury Monchi, PhD, and his postdoctoral student, Dr. Alexandru Hanganu, MD, PhD, both of whom are affiliated with Universite de Montreal. Their findings were published in the February 2014 issue of the journal Brain.

Although PD is typically tied to motor difficulties such as trembling or rigidity or trembling, individuals with this disease basically have a six times greater chance of developing dementia compared to the rest of the population. In this first longitudinal study in this field, 32 patients in the first stages of PD were followed for 20 months. Some of the patients had mild cognitive deficiencies while others did not. A control group of 18 healthy people were also monitored.

“Using magnetic resonance imaging [MRI], we found thinning in certain cortical areas as well as subcortical atrophy in the grey matter of subjects with mild cognitive impairments. Thanks to our longitudinal approach, we were able to observe that this thinning speeds up in conjunction with the increase in cognitive problems,” explained Dr. Monchi. This specific brain deterioration combined with the early presence of mild cognitive impairments could serve as markers for the development of dementia.

Dr. Monchi stressed the significance of these findings. “This study opens the door to further research, for example, on medication or on nonpharmacological approaches such as transcranial magnetic stimulation. It’s important for these patients to be identified very quickly before they develop dementia so that a therapeutic approach can be adapted to their specific needs.”

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				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 142
(!!!!! 18823.862075806): SELECT
				*
			FROM
				jos_bannersmanager_banner
			WHERE
				`groupid` = 98
			AND
				`site_id` = 10
			AND
				`published` = 143
(!!!!! 24318.218231201): SELECT
				*
			FROM
				jos_bannersmanager_banner
			WHERE
				`groupid` = 99
			AND
				`site_id` = 10
			AND
				`published` = 144
(247.00164794922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 145
(80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 146
(132.08389282227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 147
(66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 148
(80.82389831543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 149
(57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 150
(!!!!! 3408.9088439941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 151
(111.10305786133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 152
(406.02684020996): SELECT name FROM jos_deeppockets WHERE id=294751452 LIMIT 153
(375.03242492676): SELECT name FROM jos_deeppockets_archive WHERE id=294751452 LIMIT 154
(183.10546875): SELECT a.*
 FROM jos_components AS a
 WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' )
 AND a.option = 'com_syndicate'55
(95.129013061523): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294751452
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 156
(533.10394287109): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294751452
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 157
(!!!!! 9566.068649292): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 158
(267.98248291016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 159
(!!!!! 5658.1497192383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 160
(83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 161
(!!!!! 8275.9857177734): select cover from jos_number
where journalid in (5) and cover is not null
order by left(issue,2)+right(issue,2)*12 desc limit 162
(593.90068054199): SELECT fid FROM jos_deeppockets WHERE id=294751452 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294751452 AND published='1'  LIMIT 163
(62.942504882812): SELECT id,name,sponsor_text
                    FROM jos_deeppockets dp
					left outer join jos_channel_sponsor cs
					on dp.id=cs.fid
                    WHERE cat=10
                    AND TYPE='file_folder'
                    AND published=1
                    AND id=212
                    ORDER BY `ordering`64
(61.988830566406): select jos_twitters.link from jos_twitters where cat=1065
(30.994415283203): select jos_facebook.link from jos_facebook where cat=1066
(31.948089599609): select jos_google_plus.link from jos_google_plus where cat=1067
(28.848648071289): select jos_linkedin.link from jos_linkedin where cat=1068
(31.948089599609): SELECT fid FROM jos_deeppockets WHERE id=294751452 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294751452 AND published='1'  LIMIT 169
(34.809112548828): SELECT id,name,sponsor_text
                    FROM jos_deeppockets dp
					left outer join jos_channel_sponsor cs
					on dp.id=cs.fid
                    WHERE cat=10
                    AND TYPE='file_folder'
                    AND published=1
                    AND id=212
                    ORDER BY `ordering`70
(344.99168395996): SELECT fid FROM jos_deeppockets
								WHERE cat=10
								AND id=294751452
								AND (type='deeppockets_item' OR type='deeppockets_item_link') 
								AND published='1' 
								LIMIT 171
(306.12945556641): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294751452 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 172
(39.100646972656): SELECT id,name,title
 FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
			AND id != 294743300
			AND id != 294743301
			AND id != 294743302
			AND id != 294743303
			AND id != 294743304
			AND id != 294743305
			AND id != 294743306
			AND id != 294743307
			AND id != 294743308
			AND id != 294743309
			AND id != 294743310
			AND metakey != 'aacc'
		ORDER BY `ordering`73
(56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 174
(30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 175
(25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 176
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 177
(25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 178
(25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 179
(26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 180
(32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 181
(36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 182
(30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 183
(33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 184
(33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 185
(35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 186
(28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 187
(76.055526733398): SELECT fid FROM jos_deeppockets
								WHERE cat=10
								AND id=294751452
								AND (type='deeppockets_item' OR type='deeppockets_item_link') 
								AND published='1' 
								LIMIT 188
(!!!!! 2968.0728912354): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294751452 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 189
(82.969665527344): SELECT id,name,title
 FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1
			AND id != 294743300
			AND id != 294743301
			AND id != 294743302
			AND id != 294743303
			AND id != 294743304
			AND id != 294743305
			AND id != 294743306
			AND id != 294743307
			AND id != 294743308
			AND id != 294743309
			AND id != 294743310
			AND metakey != 'aacc'
		ORDER BY `ordering`90
(174.99923706055): SELECT show_live FROM jos_com_show_setting LIMIT 191
(117.06352233887): SELECT show_live FROM jos_com_show_setting LIMIT 192
(307.08312988281): SELECT show_live FROM jos_com_show_setting LIMIT 193
(651.12113952637): SELECT show_live FROM jos_com_show_setting LIMIT 194
(264.16778564453): SELECT show_live FROM jos_com_show_setting LIMIT 195
(169.99244689941): SELECT show_live FROM jos_com_show_setting LIMIT 196
(388.86070251465): SELECT show_live FROM jos_com_show_setting LIMIT 197
(746.01173400879): SELECT show_live FROM jos_com_show_setting LIMIT 198
(124.21607971191): SELECT show_live FROM jos_com_show_setting LIMIT 199
(351.90582275391): SELECT show_live FROM jos_com_show_setting LIMIT 1100
(450.84953308105): SELECT show_live FROM jos_com_show_setting LIMIT 1101
(!!!!! 1336.8129730225): SELECT show_live FROM jos_com_show_setting LIMIT 1102
(307.08312988281): SELECT show_live FROM jos_com_show_setting LIMIT 1103
(133.99124145508): SELECT show_live FROM jos_com_show_setting LIMIT 1104
(!!!!! 1362.0853424072): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1105
(72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1106
(288.00964355469): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294751452
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1107
(53.882598876953): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294751452
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1108
(73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1109
(46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1110
(71.048736572266): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							
							AND dp.id=294751452
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1111
(540.01808166504): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								
								AND dp.id=294751452
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1112
(!!!!! 2381.8016052246): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as ex
							ON ex.id = dp.author
							LEFT JOIN jos_deeppockets as dp2
							ON dp2.id = dp.fid
							WHERE dp.author != 0
							AND dp.cat = 10
							AND dp.published = 1
							AND (
								(dp.fid = 294743300)
								OR (dp.fid = 294743301)
								OR (dp.fid = 294743302)
								OR (dp.fid = 294743303)
								OR (dp.fid = 294743304)
								OR (dp.fid = 294743305)
								OR (dp.fid = 294743306)
								OR (dp.fid = 294743307)
								OR (dp.fid = 294743308)
								OR (dp.fid = 294743309)
								OR (dp.fid = 294743310)
								)
							ORDER BY RAND()
							LIMIT 1113
(657.08160400391): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as ex
							ON ex.id = dp.author
							LEFT JOIN jos_deeppockets as dp2
							ON dp2.id = dp.fid
							WHERE dp.author != 0
							AND dp.cat = 10
							AND dp.published = 1
							AND (
								(dp.fid = 294743300)
								OR (dp.fid = 294743301)
								OR (dp.fid = 294743302)
								OR (dp.fid = 294743303)
								OR (dp.fid = 294743304)
								OR (dp.fid = 294743305)
								OR (dp.fid = 294743306)
								OR (dp.fid = 294743307)
								OR (dp.fid = 294743308)
								OR (dp.fid = 294743309)
								OR (dp.fid = 294743310)
								)
							ORDER BY RAND()
							LIMIT 1114
(106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1115
(62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1116
(71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1117
(61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1118
(59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1119
(40.769577026367): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1120
(77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1121
(62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1122
(328.06396484375): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`123
(!!!!! 52180.051803589): SELECT
				*
			FROM
				jos_deeppockets
			WHERE
				jos_deeppockets.cat = 10
			AND
				jos_deeppockets.type = 'deeppockets_item'
			AND
				jos_deeppockets.published = 1
			AND
				jos_deeppockets.created + INTERVAL 14 DAY >= NOW()
			ORDER BY
				jos_deeppockets.hits DESC
			LIMIT
				7124
(639.91546630859): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294751452 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294751452 AND type='deeppockets_item' AND published='1'  LIMIT 1125
(!!!!! 18697.023391724): (
				SELECT
					dp.id,
					dp.name,
					dp.title,
					dp.video,
					dp.video_source,
					dp.created

				FROM
					jos_deeppockets AS dp

				WHERE
					dp.video != ''
				AND
					dp.video_source != ''
				AND
					dp.cat = 10
				AND
					dp.published = 1
				AND
					dp.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			UNION
			(
				SELECT
					dpa.id,
					dpa.name,
					dpa.title,
					dpa.video,
					dpa.video_source,
					dpa.created

				FROM
					jos_deeppockets_archive AS dpa

				WHERE
					dpa.video != ''
				AND
					dpa.video_source != ''
				AND
					dpa.cat = 10
				AND
					dpa.published = 1
				AND
					dpa.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			ORDER BY
				created DESC

			LIMIT
				3126
(78.916549682617): (
				SELECT
					dp.id,
					dp.name,
					dp.title,
					dp.video,
					dp.video_source,
					dp.created

				FROM
					jos_deeppockets AS dp

				WHERE
					dp.video != ''
				AND
					dp.video_source != ''
				AND
					dp.cat = 10
				AND
					dp.published = 1
				AND
					dp.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			UNION
			(
				SELECT
					dpa.id,
					dpa.name,
					dpa.title,
					dpa.video,
					dpa.video_source,
					dpa.created

				FROM
					jos_deeppockets_archive AS dpa

				WHERE
					dpa.video != ''
				AND
					dpa.video_source != ''
				AND
					dpa.cat = 10
				AND
					dpa.published = 1
				AND
					dpa.type != 'deeppockets_item_link'

				

				ORDER BY
					created DESC

				LIMIT
					3
			)
			ORDER BY
				created DESC

			LIMIT
				3127
(60.081481933594): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294803337

			LIMIT 1128
(42.200088500977): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294803337

			LIMIT 1129
(46.014785766602): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294803276

			LIMIT 1130
(36.954879760742): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294803276

			LIMIT 1131
(330.92498779297): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets_archive AS dp

			WHERE
				dp.id = 294803276

			LIMIT 1132
(36.001205444336): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets_archive AS dp

			WHERE
				dp.id = 294803276

			LIMIT 1133
(32.186508178711): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294802958

			LIMIT 1134
(32.186508178711): SELECT
				dp.id,
				dp.name,
				dp.title,
				dp.video,
				dp.video_source,
				dp.created

			FROM
				jos_deeppockets AS dp

			WHERE
				dp.id = 294802958

			LIMIT 1135
(488.0428314209): SELECT *
                            FROM jos_deeppockets
                            WHERE 1=1 
                              AND id=294751452
                              AND (type='deeppockets_item' OR type='deeppockets_item_link')
                              AND published='1'
                            LIMIT 1136
(403.88107299805): SELECT *
                            FROM jos_deeppockets_archive
                            WHERE 1=1 
                              AND id=294751452
                              AND (type='deeppockets_item' OR type='deeppockets_item_link')
                              AND published='1'
                            LIMIT 1137
(41.007995605469): SELECT name FROM jos_deeppockets WHERE id=212138
(29.087066650391): SELECT name FROM jos_deeppockets WHERE id=212139
(708.10317993164): SELECT *,
    DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
    DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
    FROM jos_events
    WHERE state=1
    AND publish_up > NOW()
    and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) 
    ORDER BY publish_up ASC LIMIT 3140
(627.04086303711): SELECT *,
    DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up,
    DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down
    FROM jos_events
    WHERE state=1
    AND publish_up > NOW()
    and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) 
    ORDER BY publish_up ASC LIMIT 3141
(!!!!! 3972.053527832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1142
(100.13580322266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1143
(!!!!! 20007.133483887): TRUNCATE TABLE jos_trademed_module144
(95.844268798828): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp
							LEFT JOIN jos_experts as exp
							ON exp.id = dp.author
							LEFT JOIN jos_deeppockets as ch
							ON dp.fid = ch.id
							WHERE 1=1
							 AND dp.cat=10 
							AND dp.id=294751452
							AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
							AND dp.published='1' LIMIT 1145
(576.01928710938): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp
								LEFT JOIN jos_experts as exp
								ON exp.id = dp.author
								LEFT JOIN jos_deeppockets as ch
								ON dp.fid = ch.id
								WHERE 1=1
								 AND dp.cat=10 
								AND dp.id=294751452
								AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link')
								AND dp.published='1' LIMIT 1146
(!!!!! 3659.0099334717): SELECT *
   FROM jos_deeppockets
   WHERE 1=1 
   AND id=294751452
   AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1147
(114.91775512695): SELECT *
   FROM jos_deeppockets
   WHERE 1=1 
   AND id=294751452
   AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1148
(83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1149
(46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1150
(!!!!! 1342.0581817627): SELECT jos_item.*
						FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id
						WHERE 1=1
						AND (jos_item.imgMini<>'')
						AND jos_item.type='L'
						AND jos_item.numberID= (
									 SELECT jos_number.id
									 FROM jos_number
									 WHERE jos_number.journalID IN (10)
						
									and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P')
									 ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC
									 LIMIT 0,1
									 )
						ORDER BY RAND() DESC LIMIT 6151
(103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1152
(48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1153
(48.160552978516): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294751452 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294751452 AND type='deeppockets_item' AND published='1'  LIMIT 1154
(53.882598876953): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=212 or channel_id is null)155
(32.901763916016): select distinct links.*
from jos_textlinks links
join jos_textlinks_placement placement on links.id=placement.link_id
where journal_id=(10) and (channel_id=212 or channel_id is null)156
(36.001205444336): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1157
(89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1158
(46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294751452 AND published='1'
				union
		SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294751452 AND published='1'
		LIMIT 1159
(43.869018554688): select jos_twitters.link from jos_twitters where cat=10160
(29.087066650391): select jos_facebook.link from jos_facebook where cat=10161
(28.848648071289): select jos_google_plus.link from jos_google_plus where cat=10162
(30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10163
(391.96014404297): update jos_bannersmanager_banner
			set impmade=impmade+1
			where id in(14615,14202,14203)164
(!!!!! 1240.9687042236): insert into jos_banners_delta values (14615,'2025-06-24 06:55:39','216.73.216.120','view'),(14202,'2025-06-24 06:55:39','216.73.216.120','view'),(14203,'2025-06-24 06:55:39','216.73.216.120','view')

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