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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Multifunctional Nanoparticle Targets Blood Vessel Plaques

By MedImaging International staff writers
Posted on 20 Feb 2014

Image: The typical mosaic pattern on flue-cured tobacco leaves infected with Tobacco mosaic virus (Photo courtesy of H.D. Shew).

A multifunctional nanoparticle has been designed that enables magnetic resonance imaging (MRI) to locate blood vessel plaques caused by atherosclerosis. The technology is a cutting-edge way of identifying plaques susceptible to rupture—the cause of heart attack and stroke—in time for treatment.

Currently, physicians can identify only blood vessels that are narrowing due to plaque accumulation. A doctor makes an incision and places a catheter inside a blood vessel in the arm, groin, or neck. The catheter emits a dye that enables X-rays to reveal the narrowing. However, Case Western Reserve University (Cleveland, OH, USA) researchers reported online February 7, 2014, in the journal Nano Letters that a nanoparticle built from a rod-shaped virus typically found on tobacco pinpoints and illuminates plaque in arteries more effectively and with a tiny fraction of the dye.

The research, more significantly, shows that the customized nanoparticles home in on plaque biomarkers. That creates a way for that particles can be programmed to identify vulnerable plaques from stable, something untargeted dyes alone cannot. “From a chemist’s point of view, it’s still challenging to make nanoparticles that are not spherical, but non-spherical materials are advantageous for medical applications,” said Dr. Nicole F. Steinmetz, assistant professor of biomedical engineering at Case Western Reserve. “Nature is way ahead of us. We’re harvesting nature's methods to turn them into something useful in medicine.”

The rod-shaped nanoparticles are made from Tobacco mosaic virus, tiny tubular organisms that infect plant cells but are benign outside the plant. Dr. Steinmetz, a specialist in bioengineering plant viruses, teamed with Dr. Xin Yu, a professor of biomedical engineering, who specializes in developing MRI techniques to investigate cardiovascular diseases. They created a device that transports and concentrates imaging agents on plaques.

Elongated nanoparticles have a higher chance of being thrust out of the central blood flow and targeting the vessel wall compared to spheres. Further, the shape allows more stable attachment to the plaque, according to the investigators.

The virus surface is engineered to carry short chains of amino acids, called peptides, that make the virus stick where plaques are developing or already exist. Drs. Luyt and Simpson synthesized the peptides. “The binding allows the particle to stay on the site longer, whereas the sheer force is more likely to wash away a sphere, due to its high curvature,” said Dr. Yu, an appointee of the Case School of Engineering.

The virus surface was also modified to carry near-infrared dyes used for optical scanning, and gadolinium ions (which are linked with organic molecules, to reduce toxicity of the metal) used as an MRI contrasting agent. They used optical scans to verify the MRI findings. By loading the surface with gadolinium ions instead of injecting and letting them flow freely in the blood stream, the nanoparticle increases the relaxivity (contrast from healthy tissue) by more than four orders of magnitude. “The agent injected in the blood stream has a relaxivity of 5, and our nanoparticles a relaxivity of 35,000,” said Dr. Steinmetz who was appointed by the Case Western Reserve School of Medicine.

That is because the nanorod carries up to 2,000 molecules of the contrast agent, concentrating them at the plaque sites. Secondly, attaching the contrast agent to a nanoparticle scaffold reduces its molecular tumbling rates and leads to additional relaxivity benefit, the researchers explained.

While the view is better, they are able to use 400 times less of the contrast agent because it is delivered directly to plaques. The tobacco virus-based nanoparticle, they said, offers another benefit: Most nanoparticles that have been developed to carry contrast agents are based on synthetic materials, some of which may stay in the body a while.

The Tobacco mosaic virus is comprised of protein, which the body is can easily handle and clear from the system rapidly. Drs. Steinmetz and Yu, members of the Case Center for Imaging Research, are now planning to take the research even further. They want to customize the nanoparticles to show doctors whether the plaques are stable and require no treatment, or are vulnerable to rupture and require treatment. A rupture initiates the cascade of events that lead to heart attack and stroke.

To achieve this, the scientists have to first find different biomarkers of stable instead of vulnerable plaques and coat the nanoparticles with different peptides and contrast agents that enable the MRI scanning to identify one from the other. “Our understanding of vulnerable plaques is incomplete, but once we can diagnose vulnerable plaques from stable plaques, it will be a paradigm shift in diagnosis and prognosis,” Dr. Yu said.

The new technology may also useful for delivering medicines and monitoring treatment, in addition to using it to find vulnerabilities, according to the researchers.

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56 (498.05641174316): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750829 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

57 (!!!!! 1445.7702636719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

58 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

59 (126.83868408203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

60 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

61 (119.92454528809): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (619.17304992676): SELECT fid FROM jos_deeppockets WHERE id=294750829 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294750829 AND published='1' LIMIT 1

63 (370.97930908203): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (58.889389038086): select jos_twitters.link from jos_twitters where cat=10

65 (36.954879760742): select jos_facebook.link from jos_facebook where cat=10

66 (37.908554077148): select jos_google_plus.link from jos_google_plus where cat=10

67 (35.04753112793): select jos_linkedin.link from jos_linkedin where cat=10

68 (39.100646972656): SELECT fid FROM jos_deeppockets WHERE id=294750829 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294750829 AND published='1' LIMIT 1

69 (42.915344238281): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (393.15223693848): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750829 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (304.22210693359): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750829 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (61.988830566406): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (73.909759521484): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (61.03515625): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750829 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (39.815902709961): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750829 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (44.822692871094): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (66.995620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (61.03515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

105 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

106 (77.009201049805): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750829 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (68.187713623047): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750829 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

109 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

110 (88.930130004883): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750829 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (521.89826965332): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750829 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (682.83081054688): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (442.0280456543): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

115 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

116 (74.863433837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

117 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

118 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

119 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

120 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

121 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

122 (246.04797363281): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 29006.004333496): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (498.05641174316): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750829 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750829 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 9662.1513366699): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (88.930130004883): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (261.06834411621): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (51.975250244141): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (165.93933105469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (43.153762817383): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (152.1110534668): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (49.114227294922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (155.92575073242): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (419.85511779785): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (369.07196044922): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (200.03318786621): SELECT name FROM jos_deeppockets WHERE id=212

138 (44.822692871094): SELECT name FROM jos_deeppockets WHERE id=212

139 (710.96420288086): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (623.94142150879): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

142 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

143 (!!!!! 11029.005050659): TRUNCATE TABLE jos_trademed_module

144 (122.0703125): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750829 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (74.863433837891): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750829 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (566.00570678711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

149 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

150 (!!!!! 1625.0610351562): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

152 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

153 (47.922134399414): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750829 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750829 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (43.153762817383): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (41.007995605469): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (58.889389038086): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (157.83309936523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

158 (65.803527832031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750829 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750829 AND published='1' LIMIT 1

159 (156.87942504883): select jos_twitters.link from jos_twitters where cat=10

160 (41.961669921875): select jos_facebook.link from jos_facebook where cat=10

161 (41.961669921875): select jos_google_plus.link from jos_google_plus where cat=10

162 (41.007995605469): select jos_linkedin.link from jos_linkedin where cat=10

163 (349.99847412109): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1161.0984802246): insert into jos_banners_delta values (14615,'2025-06-24 11:48:41','216.73.216.120','view'),(14202,'2025-06-24 11:48:41','216.73.216.120','view'),(14203,'2025-06-24 11:48:41','216.73.216.120','view')

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