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MRI Helps Identify and Treat Irritable Bowel Syndrome

By MedImaging International staff writers
Posted on 20 Jan 2014

British scientists are utilizing magnetic resonance imaging (MRI) technology to assist in the treatment and diagnosis of irritable bowel syndrome (IBS), a disorder that causes serious discomfort and distress to sufferers.

In three separate studies, researchers examined the disorder and found another way of examining the condition, which could have major implications in how it is both diagnosed and treated in the future.

The three studies explored the effectiveness of using MRI to evaluate the colon, which has a number of novel advantages. Before this, clinicians have relied on -rays to view the colon, which has limitations due to the risks tied to radiation. By using MRI as an alternative, the researchers have been able to image the bowel continuously with no risk to the patient, enabling them to learn more about the inner workings of the gut.

The research has been led by researchers from the University of Nottingham’s (UK) Digestive Diseases Center (NDDC) and scientists from the Sir Peter Mansfield Magnetic Resonance Center at the University. In the first study, published in the January 2014 issue of the journal Neurogastroenterology and Motility, scientists were able to image the colon and split it in to three functional regions: the ascending colon, which is a storage and fermentation region, where unabsorbed residue is broken down by bacteria; the transverse colon, which is a storage area for the residue left after bacterial processing, and the descending colon, which is an organ that pushes waste down and out of the body.

Using MRI, scientists can also measure the volumes of these regions, which they have never been able to do before. Prof. Robin Spiller, lead director of Nottingham digestive diseases biomedical research unit, said, “We studied people with accelerated transit and to our surprise, we found that the colon size was rather similar to those with normal transit suggesting people regulate their bowel habit to keep the colonic size constant. We also know that when you eat a meal the ascending colon expands as the meal is pushed down into it to make space in the small bowel for the new meal. We found that this increase was smaller in IBS patients than in healthy volunteers, suggesting that the IBS patient’s ascending colon can’t relax enough. With MRI, we can actually measure this change in a way that we’ve never been able to do before. This will have other benefits in the future, for instance we will be able to measure the effect of some drugs on the bowel.”

In the second study, published in the January 2014 issue of the journal Neurogastroenterology and Motility, scientists used MRI scanning to gauge the actual time it takes for contents to transit the bowel, using specially designed MRI visible markers, which subjects ingest. Scientists can then image the bowel 24 hours later to see how far they have moved. Previously, motility had to be measured using X-rays, which has extremely limited the circumstances when the measurement could be made.

In the third study, published online November 19, 2013, in American Journal of Gastroenterology, researchers used the colonic imaging technique again, but this time, to improve their understanding of the causes of IBS. By looking at fructose, a sugar commonly found in fruit, and fructans, which are polymers of fructose, researchers were able see what effects these had on the gut of healthy study participants. “We already know that fructose is difficult to absorb, but the novelty with this new method, is that we are now able to image the end effect of this malabsorption which is the distension of the small intestine and colon. We are currently repeating these studies in patients with IBS to see whether their symptoms correlate with the distension of the colon.”

Fructans and fructose are part of a group of chemicals called FODMAPs (fermentable oligo, di- monosaccharides and polyhydric) alcohols, whose characteristics are that they are comparatively tough to absorb, but they are fermentable, so when they go in to the colon they are exposed to the bacteria and produce gas.

Prof. Spiller continued, “It’s been found that diets that restrict the intake of these things improve symptoms and our MRI studies show us scientifically why that improvement might occur. We were able to show that while fructose alone was poorly absorbed and distended the small bowel, when it was combined with glucose the poor absorption was prevented. We also found that fructans have little effect in the small bowel but a large effect on the colon. In future, will be able to use our MRI techniques to test specific foods to understand how they will affect IBS.

“By defining the link between the chemistry of food to its impact on the bowel our technique will enable us to answer specific questions, e.g., when an apple ripens and the sugar content rise, does the adverse effect reduce? This might explain why green apples can cause stomachache while ripe ones do not. The fructose in the green apple is malabsorbed but as it ripens the glucose content rises improves fructose absorption, improving the rate of absorption.”

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56 (509.97734069824): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750230 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

57 (!!!!! 1265.0489807129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

58 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

59 (198.1258392334): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

60 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

61 (143.05114746094): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (658.03527832031): SELECT fid FROM jos_deeppockets WHERE id=294750230 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294750230 AND published='1' LIMIT 1

63 (444.17381286621): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (70.095062255859): select jos_twitters.link from jos_twitters where cat=10

65 (40.054321289062): select jos_facebook.link from jos_facebook where cat=10

66 (41.007995605469): select jos_google_plus.link from jos_google_plus where cat=10

67 (32.901763916016): select jos_linkedin.link from jos_linkedin where cat=10

68 (51.021575927734): SELECT fid FROM jos_deeppockets WHERE id=294750230 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294750230 AND published='1' LIMIT 1

69 (51.975250244141): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (!!!!! 1076.9367218018): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750230 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (341.89224243164): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750230 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (44.822692871094): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (120.87821960449): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (52.213668823242): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (72.956085205078): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 4713.0584716797): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750230 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (241.04118347168): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750230 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (99.897384643555): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (72.956085205078): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 4030.9429168701): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

105 (148.05793762207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

106 (102.99682617188): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750230 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (777.9598236084): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750230 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

109 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

110 (78.916549682617): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750230 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (560.99891662598): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294750230 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (709.05685424805): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (452.04162597656): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (105.85784912109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

115 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

116 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

117 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

118 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

119 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

120 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

121 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

122 (297.06954956055): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 46475.887298584): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (567.91305541992): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750230 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750230 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 16122.102737427): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (101.08947753906): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (388.86070251465): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (313.04359436035): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (43.869018554688): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (229.1202545166): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (250.81634521484): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (46.014785766602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (570.05882263184): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (420.09353637695): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (288.00964355469): SELECT name FROM jos_deeppockets WHERE id=212

138 (36.001205444336): SELECT name FROM jos_deeppockets WHERE id=212

139 (622.03407287598): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (679.96978759766): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (104.90417480469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

142 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

143 (!!!!! 18193.006515503): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 3812.0746612549): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750230 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (191.92695617676): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294750230 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 1176.118850708): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

149 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

150 (!!!!! 1476.0494232178): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

152 (!!!!! 1786.2319946289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

153 (51.975250244141): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294750230 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294750230 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (602.96058654785): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (75.817108154297): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (51.021575927734): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (179.05235290527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

158 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294750230 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294750230 AND published='1' LIMIT 1

159 (61.988830566406): select jos_twitters.link from jos_twitters where cat=10

160 (35.04753112793): select jos_facebook.link from jos_facebook where cat=10

161 (38.862228393555): select jos_google_plus.link from jos_google_plus where cat=10

162 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

163 (343.79959106445): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1205.9211730957): insert into jos_banners_delta values (14615,'2025-06-24 12:02:29','216.73.216.120','view'),(14202,'2025-06-24 12:02:29','216.73.216.120','view'),(14203,'2025-06-24 12:02:29','216.73.216.120','view')

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