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Calibration Tools Used to Enhance Ultralow Field MRI Technology

By MedImaging International staff writers
Posted on 16 Dec 2013

A US technology office has developed prototype calibration tools for an experimental medical imaging technique that offers new benefits in diagnosing and tracking of specific cancers and other medical disorders.

The US National Institute of Standards and Technology (NIST; Gaithersburg, MD, USA) designed, built, and evaluated two prototype phantoms for calibrating ultralow-field (ULF) magnetic resonance imaging (MRI) systems. More...

The NIST prototypes are the first standard calibration tools for ULF-MRI, offering a quantitative means to assess performance, validate the technique, and directly compare different experimental and clinical MRI scanners. “Tissues that may look the same in clinical MRI can look very different in ULF-MRI, which provides new contrast mechanisms,” NIST physicist Dr. Michael Boss stated. “Our hope is that we can move this technique along to attract more interest from [industry] vendors.”

MRI noninvasively images soft tissues based on measurements of how hydrogen nuclei respond to magnetic fields. ULF-MRI enhances tissue contrast in specific types of MRI scans. Prostate tumors, for example, can be difficult to see with conventional MRI but show up clearly under ULF-MRI. ULF-MRI has also been used in research approaches to image the brain, and assessed in at least one nonmedical application, inspection of liquids at airports.

ULF-MRI also offers practical advantages: the systems are more streamlined, lighter in weight, and less costly than conventional MRI scanners. That is because ULF-MRI operates at much lower magnetic field strengths, measured in micro-Teslas, thousands of times lower than conventional MRI, which operates at up to 3 Teslas and requires large magnets. The low magnetic field strength means ULF-MRI requires the most sensitive magnetometers available: superconducting quantum interference devices (SQUIDs). This is convenient in that it makes ULF-MRI suitable for combining with other SQUID-based imaging techniques such as magnetoencephalography.

NIST scientists earlier designed phantoms for standard MRI systems and also have extensive experience both making and using SQUIDs. NIST’s new ULF-MRI phantoms are short plastic cylinders, shaped like hockey pucks but a bit smaller, containing six or 10 plastic jars filled with various salt solutions that become magnetized in a magnetic field. Each phantom measures a different aspect of scanner performance such as spatial resolution. NIST researchers tested the new phantoms on both a conventional MRI system at the University of Colorado Health Sciences Center (Denver, CO, USA) and a research ULF-MRI scanner at the University of California (UC) at Berkeley, where the technique was first demonstrated about than 10 years ago.

Tests findings revealed that the prototype phantoms are well matched to ULF-MRI applications and they allow direct comparison of ULF and clinical MRI system performance. NIST researchers now plan to integrate design improvements based on lessons gleaned from the prototypes, with the aim of improving phantom stability and providing traceability to standard measurement units. NIST and the University of California (UC) Berkeley (USA) researchers also plan to work together to develop ULF-MRI technology for the detection of prostate and breast cancers.

NIST’s phantoms for conventional MRI systems are currently being tested by hospitals and MRI manufacturers, and Sigma-K Corp. (Durham, NC, USA) is devising ways for making copies for more widespread distribution under a NIST Small Business Innovation Research Award (SBIR).

The study’s findings were published online November 26, 2013, in the journal Magnetic Resonance in Medicine.

Related Links:
National Institute of Standards and Technology
University of California, Berkeley
Sigma-K

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57 (669.95620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749708 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

58 (!!!!! 1700.8781433105): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

59 (134.94491577148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

60 (272.98927307129): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

61 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

62 (139.95170593262): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

63 (670.9098815918): SELECT fid FROM jos_deeppockets WHERE id=294749708 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294749708 AND published='1' LIMIT 1

64 (70.095062255859): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

65 (112.05673217773): select jos_twitters.link from jos_twitters where cat=10

66 (56.982040405273): select jos_facebook.link from jos_facebook where cat=10

67 (51.021575927734): select jos_google_plus.link from jos_google_plus where cat=10

68 (144.95849609375): select jos_linkedin.link from jos_linkedin where cat=10

69 (74.148178100586): SELECT fid FROM jos_deeppockets WHERE id=294749708 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294749708 AND published='1' LIMIT 1

70 (77.009201049805): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

71 (517.84515380859): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749708 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (339.03121948242): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749708 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (45.061111450195): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

74 (94.890594482422): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (79.154968261719): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (47.206878662109): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (58.889389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (42.200088500977): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (66.041946411133): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749708 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (31.948089599609): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749708 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (36.954879760742): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

91 (67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (59.843063354492): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (40.769577026367): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (68.902969360352): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (130.89179992676): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

106 (79.870223999023): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

107 (101.08947753906): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749708 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749708 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (139.95170593262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

110 (169.03877258301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

111 (76.055526733398): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294749708 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (694.99015808105): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294749708 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (943.89915466309): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (683.06922912598): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

115 (200.03318786621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

116 (119.92454528809): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

117 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

118 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

119 (128.98445129395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

120 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

121 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

122 (124.93133544922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

123 (576.01928710938): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

124 (!!!!! 30893.802642822): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

125 (730.99136352539): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749708 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749708 AND type='deeppockets_item' AND published='1' LIMIT 1

126 (!!!!! 11554.002761841): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (127.07710266113): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

128 (59.127807617188): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

130 (83.92333984375): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (40.769577026367): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

132 (449.89585876465): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (56.028366088867): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

134 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

136 (675.91667175293): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (556.94580078125): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

138 (62.942504882812): SELECT name FROM jos_deeppockets WHERE id=212

139 (42.915344238281): SELECT name FROM jos_deeppockets WHERE id=212

140 (825.88195800781): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (799.89433288574): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

142 (110.86463928223): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

143 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

144 (!!!!! 12537.002563477): TRUNCATE TABLE jos_trademed_module

145 (587.94021606445): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749708 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (593.18542480469): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749708 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

147 (598.90747070312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (174.99923706055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

149 (741.00494384766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

150 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

151 (!!!!! 1742.1245574951): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

152 (122.0703125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

153 (79.870223999023): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

154 (87.02278137207): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749708 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749708 AND type='deeppockets_item' AND published='1' LIMIT 1

155 (94.890594482422): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (46.968460083008): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

157 (66.995620727539): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

158 (145.91217041016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

159 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749708 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749708 AND published='1' LIMIT 1

160 (37.908554077148): select jos_twitters.link from jos_twitters where cat=10

161 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

162 (37.908554077148): select jos_google_plus.link from jos_google_plus where cat=10

163 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

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