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Personal Contemplation Triggers Increased Brain Activity during Depressive Episodes

By MedImaging International staff writers
Posted on 21 Nov 2013

Image: The study used fMRI to analyze the brain while participants chose positive, negative, and neutral adjectives to describe either themselves or the British Queen (Photo courtesy of the University of Liverpool).

British investigators have shown that people experiencing depressive attacks display increased brain activity when they think about themselves.

Using functional magnetic resonance imaging (fMRI) brain imaging technologies, the scientists, from the University of Liverpool (UK), discovered that individuals experiencing a depressive episode process data about themselves in the brain differently to people who are not depressed.

Researchers scanned the brains of people in major depressive episodes and those that weren't while they chose positive, negative and neutral adjectives to describe either themselves or the British Queen—a figure considerably separated from their daily lives but one that all study participants were familiar with.

Prof. Peter Kinderman, head of the University’s Institute of Psychology, Health, and Society, said, “We found that participants who were experiencing depressed mood chose significantly fewer positive words and more negative and neutral words to describe themselves, in comparison to participants who were not depressed. That’s not too surprising, but the brain scans also revealed significantly greater blood oxygen levels in the medial superior frontal cortex when the depressed participants were making judgments about themselves. This research leads the way for further studies into the psychological and neural processes that accompany depressed mood. Understanding more about how people evaluate themselves when they are depressed, and how neural processes are involved could lead to improved understanding and care.”

Dr. May Sarsam, from the Mersey Care NHS (National Health Service) Trust (UK), said, “This study explored the difference in medical and psychological theories of depression. It showed that brain activity only differed when depressed people thought about themselves, not when they thought about the Queen or when they made other types of judgments, which fits very well with the current psychological theory. Thought and neurochemistry should be considered as equally important in our understanding of mental health difficulties such as depression.”

The study’s findings were published October 30, 2013, in the journal PLoS ONE.

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65 (38.862228393555): select jos_facebook.link from jos_facebook where cat=10

66 (42.915344238281): select jos_google_plus.link from jos_google_plus where cat=10

67 (37.908554077148): select jos_linkedin.link from jos_linkedin where cat=10

68 (41.961669921875): SELECT fid FROM jos_deeppockets WHERE id=294749283 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294749283 AND published='1' LIMIT 1

69 (39.100646972656): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (189.06593322754): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749283 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (189.06593322754): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749283 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (61.988830566406): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (!!!!! 5725.1453399658): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (112.05673217773): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (47.206878662109): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (53.882598876953): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (70.810317993164): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749283 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (39.100646972656): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749283 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (42.915344238281): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (88.930130004883): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (51.975250244141): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (!!!!! 4741.907119751): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (112.05673217773): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (64.849853515625): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (132.08389282227): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

105 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

106 (85.115432739258): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749283 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (571.01249694824): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749283 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (165.93933105469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

109 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

110 (81.062316894531): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294749283 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (577.92663574219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294749283 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 1918.7927246094): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 4137.0391845703): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (123.02398681641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

115 (80.82389831543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

116 (127.79235839844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

117 (63.180923461914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

118 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

119 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

120 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

121 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

122 (340.93856811523): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 59917.92678833): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 3756.046295166): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749283 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749283 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 18958.09173584): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 4687.7861022949): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (725.98457336426): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (60.081481933594): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (!!!!! 4990.1008605957): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (!!!!! 5179.8820495605): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (!!!!! 6606.1019897461): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (!!!!! 3597.0211029053): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (!!!!! 2074.0032196045): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (!!!!! 3767.0135498047): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (!!!!! 2231.1210632324): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (409.84153747559): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (191.92695617676): SELECT name FROM jos_deeppockets WHERE id=212

138 (51.975250244141): SELECT name FROM jos_deeppockets WHERE id=212

139 (718.11676025391): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (663.04206848145): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (95.844268798828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

142 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

143 (!!!!! 8984.0888977051): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 8835.0772857666): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749283 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (!!!!! 3041.0289764404): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294749283 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (461.10153198242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

149 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

150 (!!!!! 1118.8983917236): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

152 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

153 (36.954879760742): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294749283 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294749283 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (32.186508178711): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (30.040740966797): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (30.994415283203): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (618.93463134766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

158 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294749283 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294749283 AND published='1' LIMIT 1

159 (442.9817199707): select jos_twitters.link from jos_twitters where cat=10

160 (35.04753112793): select jos_facebook.link from jos_facebook where cat=10

161 (29.087066650391): select jos_google_plus.link from jos_google_plus where cat=10

162 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

163 (501.15585327148): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1058.1016540527): insert into jos_banners_delta values (14615,'2025-06-25 00:37:18','216.73.216.120','view'),(14202,'2025-06-25 00:37:18','216.73.216.120','view'),(14203,'2025-06-25 00:37:18','216.73.216.120','view')

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