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MRI May Reveal Infant Brain Anomaly Associated with Autism

By MedImaging International staff writers
Posted on 06 Aug 2013
Children who were diagnosed with autism spectrum disorder were found to have excessive cerebral spinal fluid and enlarged brains in infancy, according to a recent study by a multidisciplinary team of researchers, raising the possibility that those brain anomalies may serve as potential biomarkers for the early identification of the neurodevelopmental disorder.

The study is the first to track the brain-growth trajectories from infancy in children who later develop autism and the first to associate excessive cerebrospinal fluid during infancy with autism. The study was published online July 9, 2013, in the neurology journal Brain.

“This is the first report of an infant brain anomaly associated with autism that is detectable by using conventional structural MRI [magnetic resonance imaging],” said University of California (UC) Davis MIND Institute (USA ) director of research Dr. David Amaral, who co-led the study. “This study raises the potential of developing a very early method of detecting autism spectrum disorder. Early detection is critical, because early intervention can decrease the cognitive and behavioral impairments associated with autism and may result in more positive long-term outcomes for the child.”

The study was conducted in 55 infants between 6 and 36 months of age, 33 of whom had an older sibling with autism. Twenty-two infants were children with no family history of the disorder. The researchers reported that the brain anomaly was detected substantially more frequently in the high-risk infants who were later diagnosed with autism between 24 and 36 months. Earlier studies by Dr. Sally Ozonoff, the vice chair for research and professor in the department of psychiatry and behavioral sciences, who co-led the study, has shown that the risk of autism is nearly 20 times greater in siblings of children with autism than in the general population. The US Centers for Disease Control and Prevention (Atlanta, GA, USA) puts the overall incidence of autism at one in 88.

The excessive cerebrospinal fluid and enlarged brain volume were identified by intermittently measuring the infant’s brain growth and development using magnetic resonance imaging (MRI), and by routinely evaluation their cognitive, social, communication and motor development. Both the high- and low-risk infants underwent their first MRI scans at six to nine months. The second MRI scans occurred when they were 12 to 15 months old. The third was conducted between 18 and 24 months. The MRI scans were performed while the infants were sleeping naturally, without the need for sedation or anesthesia.

At six months, the researchers began intensive behavioral assessments of the babies’ development. Their parents also periodically completed questionnaires about their infants’ behaviors. These scans were conducted until the infants were 24 to 36 months old, when each child was evaluated as having autism spectrum disorder, other developmental delays, or typical development.

In addition to the 10 children diagnosed with autism, 24% of the high risk, and 13.5% of the low-risk infants were classified as having other developmental delays. Some 45.5% of high-risk and over 86% of low-risk infants were found to be developing normally. The researchers found that by six to nine months of age, the children who developed autism had elevated cerebrospinal fluid levels in the “extra-axial” space above, and surrounding the brain, and that those fluid levels remained abnormally elevated between 18 to 24 months of age. The more fluid during early infancy, the more severe were the child's autism symptoms when diagnosed, the study found.

In the infants who would go on to be diagnosed with autism, the extra-axial fluid volume was, on average, 33% greater at 12 to 15 months and 22% greater at 18 to 24 months, when compared with typically developing infants. At six to nine months, the extra-axial fluid volume was 20 percent greater, when compared with typically developing infants.

The study also provided the first MRI evidence of brain enlargement in autism prior to 24 months. On average, the infants in the study diagnosed with autism had 7% larger brain volumes at 12 months, compared with the typically developing infants. The excessive extra-axial fluid and enlarged brain volume were detected by brain imaging before behavioral signs of autism were evident. “The cause of the increased extra-axial fluid and enlarged brain size is currently unknown,” Dr. Amaral said.

Early diagnosis may be especially beneficial to infants whose older siblings have been diagnosed with autism, but the researchers stressed that this finding must be repeated before it could help in the early ddetection of ASD. The MIND Institute is now working with other research institutions to confirm these findings and to assess how well the potential biomarker can effectively predict a later diagnosis of ASD.

“It is critical to understand how often this brain finding is present in children who do not develop autism, as well,” said Dr. Ozonoff. “For a biomarker to be useful in predicting autism outcomes, we want to be sure it does not produce an unacceptable level of false-positives.”

“If this finding of elevated extra-axial fluid is replicated in a larger sample of infants who develop autism, and it accurately distinguishes between infants who do not develop autism, it has the potential of becoming a noninvasive biomarker that would aid in early detection, and ultimately improve the long-term outcomes of these children through early intervention,” said Mark Shen, UC Davis graduate student and the study’s lead author.


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University of California, Davis MIND Institute



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83 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1
84 (93.936920166016): SELECT show_live FROM jos_com_show_setting LIMIT 1
85 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1
86 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1
87 (60.081481933594): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294747580 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
88 (43.869018554688): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294747580 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
89 (41.961669921875): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
90 (63.896179199219): SELECT show_live FROM jos_com_show_setting LIMIT 1
91 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1
92 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (77.962875366211): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
105 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
106 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294747580 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (53.167343139648): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294747580 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
109 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
110 (54.121017456055): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294747580 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (694.03648376465): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294747580 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (618.93463134766): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (418.90144348145): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (106.8115234375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
115 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
116 (171.18453979492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
117 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
118 (142.09747314453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
119 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
120 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
121 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
122 (322.10350036621): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
123 (!!!!! 20264.148712158): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
124 (469.92301940918): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294747580 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294747580 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (!!!!! 7313.9667510986): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (98.943710327148): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
128 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
130 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (364.06517028809): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
132 (58.889389038086): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (49.114227294922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
134 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (568.15147399902): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
136 (515.93780517578): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (264.16778564453): SELECT name FROM jos_deeppockets WHERE id=212
138 (40.054321289062): SELECT name FROM jos_deeppockets WHERE id=212
139 (750.06484985352): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
140 (553.13110351562): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
142 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
143 (!!!!! 8350.8491516113): TRUNCATE TABLE jos_trademed_module
144 (116.10984802246): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294747580 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
145 (88.930130004883): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294747580 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (950.81329345703): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
147 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
149 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
150 (!!!!! 1529.9320220947): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
151 (73.909759521484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
152 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
153 (54.121017456055): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294747580 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294747580 AND type='deeppockets_item' AND published='1' LIMIT 1
154 (463.00888061523): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)
155 (44.107437133789): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)
156 (60.081481933594): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
157 (144.00482177734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
158 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294747580 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294747580 AND published='1' LIMIT 1
159 (52.928924560547): select jos_twitters.link from jos_twitters where cat=10
160 (38.14697265625): select jos_facebook.link from jos_facebook where cat=10
161 (40.054321289062): select jos_google_plus.link from jos_google_plus where cat=10
162 (76.055526733398): select jos_linkedin.link from jos_linkedin where cat=10
163 (382.90023803711): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)
164 (!!!!! 1131.0577392578): insert into jos_banners_delta values (14615,'2025-06-25 09:33:04','216.73.216.120','view'),(14202,'2025-06-25 09:33:04','216.73.216.120','view'),(14203,'2025-06-25 09:33:04','216.73.216.120','view')