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27 Jul 2025 - 30 Jul 2025

AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

MRI-Guided Device Helps Deliver Cancer Drug to the Brain

By MedImaging International staff writers
Posted on 27 May 2013

Image: MRI Interventions’ ClearPoint imaging system (Photo courtesy of MRI Interventions).

A trial of a new cancer drug was recently initiated to treat an aggressive brain tumor, glioblastoma multiforme. To deliver the investigational new drug, a magnetic resonance imaging (MRI)-guided delivery device is being used to allow for a threefold concentration of the targeted drug, allowing it to additionally “infect” cancer cells and spread throughout a tumor.

Tocagen (San Diego, CA, USA) began enrolling patients in a phase I trial of its Toca 511 cancer drug in May 2013.The first delivery device of its kind, MRI Interventions’ (Memphis, TN, USA) ClearPoint shows surgeons the target they need to hit and whether they have hit it. ClearPoint, developed with BrainLab (Feldkirchen, Germany), Siemens Healthcare (Erlangen, Germany), and Boston Scientific (Natick, MA, USA), is an US Food and Drug Administration (FDA)-approved surgical aid that enables the precise placement of instruments and devices guided by an MRI. For the delivery of drugs, ClearPoint can be utilized to place neurocatheters into the brain in a minimally invasive procedure but can also be used for deep brain stimulation, laser ablation, and biopsies, according to the company. It has been used to treat Parkinson’s disease, brain cancer, dystonia, and epilepsy.

For diseases such as brain cancer or Parkinson’s, treatment requires agents to be delivered directly to the brain, a surgical procedure that, in many instances, must be performed blind. But with Clearpoint’s MRI-guided system, surgeons can visualize drugs as they enter the brain, allowing for a safer and more targeted procedure.

The frame itself is applied to a patient’s head and it guides the catheter into the brain. Meanwhile, the patient is in an MRI apparatus, and the video feeds to a monitor used by the surgeon. Being able to validate the drug’s release at the targeted site is crucial to knowing whether a certain drug is doing what it needs to be doing, according to Dr. Jenkins. “It’s the ‘delivery effect versus the drug effect,’” he explained. “It’s the real challenge for drug delivery,” he said. “If you’re not reaching your target, the drug’s not going to work. And by shortening the time it takes to see if a drug is working, we can cut down on systemic side effects.”

In addition to the imminent 21-patient, two-part Toca 511 trial expected to last about one year, ClearPoint is currently in use in four other clinical trials, each with new drugs to deliver to the brain. With a soft launch just two years ago, its use in hospitals only started taking off in late 2012, according to Dr. Jenkins, with 20 hospitals now using the device, 18 of which are in the United States.

“Our collaboration with Tocagen underscores the advantages of real-time MRI-guided delivery of therapeutic agents to the brain,” Dr. Jenkins said. “And we are pleased to be a key contributor to the rapid progress being achieved.”

Related Links:
Tocagen
MRI Interventions
BrainLab

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61 (135.18333435059): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (578.88031005859): SELECT fid FROM jos_deeppockets WHERE id=294746476 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294746476 AND published='1' LIMIT 1

63 (46.014785766602): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (313.04359436035): select jos_twitters.link from jos_twitters where cat=10

65 (!!!!! 1986.9804382324): select jos_facebook.link from jos_facebook where cat=10

66 (63.180923461914): select jos_google_plus.link from jos_google_plus where cat=10

67 (41.961669921875): select jos_linkedin.link from jos_linkedin where cat=10

68 (61.988830566406): SELECT fid FROM jos_deeppockets WHERE id=294746476 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294746476 AND published='1' LIMIT 1

69 (64.13459777832): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (732.1834564209): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746476 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (385.04600524902): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746476 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (43.869018554688): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (348.80638122559): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (208.13941955566): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (238.18016052246): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (283.95652770996): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (357.15103149414): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746476 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (179.05235290527): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746476 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (41.007995605469): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (359.05838012695): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (148.05793762207): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (183.10546875): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (58.889389038086): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (205.03997802734): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (203.84788513184): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (481.12869262695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

105 (153.0647277832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

106 (154.97207641602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746476 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746476 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 1151.0848999023): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

109 (211.00044250488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

110 (205.03997802734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294746476 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (!!!!! 1104.1164398193): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294746476 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (679.96978759766): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (474.92980957031): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

115 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

116 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

117 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

118 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

119 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

120 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

121 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

122 (302.07633972168): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 45178.890228271): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (487.08915710449): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746476 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746476 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 14282.2265625): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (97.990036010742): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (52.928924560547): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (32.186508178711): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (66.041946411133): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (50.067901611328): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (318.05038452148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (50.067901611328): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (801.08642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (541.92543029785): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (181.91337585449): SELECT name FROM jos_deeppockets WHERE id=212

138 (180.00602722168): SELECT name FROM jos_deeppockets WHERE id=212

139 (764.84680175781): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (821.11358642578): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (468.96934509277): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

142 (257.01522827148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

143 (!!!!! 23350.00038147): TRUNCATE TABLE jos_trademed_module

144 (481.12869262695): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746476 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (411.03363037109): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294746476 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (703.09638977051): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (385.99967956543): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (!!!!! 3101.110458374): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

149 (269.17457580566): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

150 (!!!!! 1978.874206543): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 3383.1596374512): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

152 (!!!!! 2558.9466094971): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

153 (769.85359191895): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294746476 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294746476 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (195.98007202148): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (248.90899658203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (47.922134399414): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 1146.0781097412): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

158 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294746476 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294746476 AND published='1' LIMIT 1

159 (313.99726867676): select jos_twitters.link from jos_twitters where cat=10

160 (!!!!! 3061.056137085): select jos_facebook.link from jos_facebook where cat=10

161 (54.121017456055): select jos_google_plus.link from jos_google_plus where cat=10

162 (36.954879760742): select jos_linkedin.link from jos_linkedin where cat=10

163 (!!!!! 1334.9056243896): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1146.0781097412): insert into jos_banners_delta values (14615,'2025-06-25 12:11:34','216.73.216.120','view'),(14202,'2025-06-25 12:11:34','216.73.216.120','view'),(14203,'2025-06-25 12:11:34','216.73.216.120','view')

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