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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Imaging for Alzheimer’s Also Predicts Cognitive Decline in Parkinson’s

By MedImaging International staff writers
Posted on 26 Dec 2011

A new way of classifying brain atrophy patterns in Alzheimer’s disease patients using magnetic resonance imaging (MRI) scans can also identify cognitive decline in Parkinson’s disease, according to a new study.

Researchers also found that higher baseline Alzheimer’s patterns of atrophy predicted long-term cognitive decline in cognitively normal Parkinson’s patients. The study was published online December 2011 in the journal Brain.

“On the basis of a simple neuroimaging study, we can now predict which patients with Parkinson’s disease will experience long-term cognitive decline or develop dementia in the future,” said the study’s lead author, Daniel Weintraub, MD, associate professor of geriatric psychiatry with Perelman School of Medicine at the University of Pennsylvania (Philadelphia, USA) and the Philadelphia Veterans Affairs Medical Center. “Diagnostic tests like this can help us determine which patients would benefit from future clinical trials of medications aiming to stave off or prevent dementia progression in Parkinson’s disease.”

This research raises the possibility that both Alzheimer’s disease and Parkinson’s disease pathology contribute to cognitive decline in Parkinson’s disease. Scientists are still not sure whether the neurodegeneration seen in these patients is caused by primary Parkinson’s disease pathology, Alzheimer’s pathology, a combination of the two, or is a form of compensation.

As biomarkers for Alzheimer’s and Parkinson’s disease continue to emerge, the researchers suggest at least an overlap in regions undergoing neurodegeneration with cognitive decline, and point to the Spatial Pattern of Abnormalities for Recognition of Alzheimer’s disease (SPARE-AD) classification system to detect brain atrophy in Parkinson's disease, to detect patients at imminent risk of cognitive decline before clinically identifiable symptoms emerge.

Approximately 80% of Parkinson’s patients become demented over the course of the disorder. Some patients experience cognitive impairment comparatively soon after the disease hits, whereas others will not experience dementia until the very end of their disease. Duration and severity of the disease and advanced age are risk factors for dementia, whereas nearly almost 20% of patients never have dementia. Over half of Parkinson’s patients with dementia have significant signs of Alzheimer’s disease-related plaques and neurofibrillary tangles on autopsy, and similar brain regions, such as the hippocampus and medial temporal lobe, have been reported to be affected in both diseases.

The Penn research team applied a pattern classification individual-based score, the SPARE-AD score, to a cross-sectional cohort of 84 Parkinson’s patients including patients with dementia, mild cognitive impairment, and no dementia. In the cross-sectional analyses, the SPARE-AD score correlated to cognitive impairment across all groups. From this group, 59 Parkinson’s patients without dementia were monitored for an additional two years. Researchers determined that a higher baseline SPARE-AD score predicted worsening cognitive performance over time, even in those patients with normal cognition at baseline.

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Perelman School of Medicine at the University of Pennsylvania

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62 (547.88589477539): SELECT fid FROM jos_deeppockets WHERE id=294738593 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294738593 AND published='1' LIMIT 1

63 (339.03121948242): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (41.961669921875): select jos_twitters.link from jos_twitters where cat=10

65 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

66 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

67 (27.894973754883): select jos_linkedin.link from jos_linkedin where cat=10

68 (31.948089599609): SELECT fid FROM jos_deeppockets WHERE id=294738593 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294738593 AND published='1' LIMIT 1

69 (31.948089599609): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (247.00164794922): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294738593 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (261.06834411621): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294738593 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (38.14697265625): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (65.088272094727): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (40.769577026367): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (71.048736572266): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294738593 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (38.862228393555): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294738593 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (33.855438232422): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (82.015991210938): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (47.922134399414): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (100.13580322266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

105 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

106 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294738593 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (47.922134399414): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294738593 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

109 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

110 (61.988830566406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294738593 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (555.99212646484): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294738593 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (802.99377441406): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (474.92980957031): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (117.77877807617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

115 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

116 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

117 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

118 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

119 (40.054321289062): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

120 (42.200088500977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

121 (38.14697265625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

122 (271.08192443848): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 21217.107772827): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (591.99333190918): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294738593 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294738593 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 8028.0303955078): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (79.870223999023): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (38.862228393555): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (39.100646972656): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (457.0484161377): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (60.796737670898): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (591.03965759277): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (444.88906860352): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (305.17578125): SELECT name FROM jos_deeppockets WHERE id=212

138 (43.869018554688): SELECT name FROM jos_deeppockets WHERE id=212

139 (612.02049255371): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (461.10153198242): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (104.18891906738): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

142 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

143 (!!!!! 9281.8737030029): TRUNCATE TABLE jos_trademed_module

144 (133.99124145508): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294738593 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (93.936920166016): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294738593 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (892.87757873535): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (276.80397033691): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

149 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

150 (!!!!! 1441.9555664062): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

152 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

153 (50.067901611328): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294738593 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294738593 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (69.141387939453): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (33.855438232422): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (34.093856811523): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (106.0962677002): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

158 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738593 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738593 AND published='1' LIMIT 1

159 (36.954879760742): select jos_twitters.link from jos_twitters where cat=10

160 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

161 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

162 (39.100646972656): select jos_linkedin.link from jos_linkedin where cat=10

163 (300.16899108887): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1032.1140289307): insert into jos_banners_delta values (14615,'2025-06-26 19:25:24','216.73.216.249','view'),(14202,'2025-06-26 19:25:24','216.73.216.249','view'),(14203,'2025-06-26 19:25:24','216.73.216.249','view')

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