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Arterial Spin Labeling Technique Used for the Diagnosis Alzheimer’s Disease

By MedImaging International staff writers
Posted on 29 Nov 2011
Researchers found a new method of detecting and monitoring Alzheimer’s disease (AD) using a novel magnetic resonance imaging (MRI) technique called arterial spin labeling (ASL) that measure changes in brain function.

The researchers determined that the ASL-MRI technique has potential as an alternative to the current standard, a specific positron emission tomography (PET) scan that requires exposure to small amounts of a radioactive glucose analog and costs approximately four-times more than an ASL-MRI. Two studies published online November 2011, in Alzheimer’s and Dementia, journal of the Alzheimer’s Association, and in Neurology, journal of the American Academy of Neurology.

ASL-MRI can be used to measure neurodegenerative alterations in a similar manner that fluorodeoxyglucose (FDG)-PET scans are currently being used to measure glucose metabolism in the brain. Both modalities correlate with cognitive decline in patients with Alzheimer's disease.
“In brain tissue, regional blood flow is tightly coupled to regional glucose consumption, which is the fuel the brain uses to function. Increases or decreases in brain function are accompanied by changes in both blood flow and glucose metabolism,” explained John A. Detre, MD, professor of neurology and radiology at Perelman School of Medicine at the University of Pennsylvania (Philadelphia, USA), senior author of the articles, who has worked on ASL-MRI for the past 20 years. “We designed ASL-MRI to allow cerebral blood flow to be imaged noninvasively and quantitatively using a routine MRI scanner.”

When AD is suspected, patients typically receive an MRI initially to look for structural changes that could indicate other medical causes, such as a stroke or brain tumor. Adding approximately 10-20 minutes to the test time, ASL can be integrated into the routine MRI and gather functional measures to detect Alzheimer’s disease upfront, turning a routine clinical test (structural MRI) into both a structural and functional test.

“If ASL-MRI were included in the initial diagnostic work-up routinely, it would save the time for obtaining an additional PET scan, which we often will order when there is diagnostic uncertainty, and would potentially speed up diagnosis,” said David Wolk, MD, assistant professor of neurology and assistant director of the Penn Memory Center, and a collaborator on this research.

The studies reported revealed a comparison of ASL-MRI and FDG-PET in a group of Alzhiemer’s patients and age-matched controls. Cerebral blood flow and glucose metabolism were measured simultaneously by injecting the PET tracer during the MRI study. The data were then analyzed two different ways.

In the first study, ASL-MRI and FDG-PET images from 13 patients diagnosed with AD and 18 age-matched controls were analyzed by visual inspection. Independent, blinded review of the two tests by expert nuclear medicine physicians demonstrated similar abilities to rule out (sensitivity) and diagnose (specificity) Alzheimer’s. Neither ASL-MRI nor FDG-PET revealed a distinct advantage from quantitative testing. In the second study, published ahead of print November 16, 2011, in the journal Neurology, the ASL-MRI and FDG-PET images were compared statistically at each location in the brain by computerized analysis. Data from 15 AD patients were compared to 19 age-matched healthy adults. The patterns of reduction in cerebral blood flow were almost indistinguishable to the patterns of reduced glucose metabolism by FDG-PET, both of which differed from the patterns of reduction in gray matter seen in AD.

“Given that ASL-MRI is entirely noninvasive, has no radiation exposure, is widely available and easily incorporated into standard MRI routines, it is potentially more suitable for screening and longitudinal disease tracking than FDG-PET,” said the study authors.

Further studies, according to the scientists, will focus on larger sample sizes including patients with mild cognitive impairment and other types of neurodegenerative disorders.

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Perelman School of Medicine at the University of Pennsylvania



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89 (31.948089599609): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
90 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1
91 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1
92 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
105 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
106 (59.843063354492): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294738207 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294738207 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
109 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
110 (72.002410888672): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294738207 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (568.86672973633): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294738207 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (596.04644775391): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (339.03121948242): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (74.148178100586): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
115 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
116 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
117 (36.001205444336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
118 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
119 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
120 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
121 (37.193298339844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
122 (329.01763916016): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
123 (!!!!! 35212.03994751): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
124 (524.99771118164): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294738207 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294738207 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (!!!!! 19793.033599854): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (277.04238891602): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (205.03997802734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
128 (221.96769714355): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (174.99923706055): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
130 (219.10667419434): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (719.07043457031): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
132 (195.98007202148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (115.87142944336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
134 (221.96769714355): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (!!!!! 1840.1145935059): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
136 (452.04162597656): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (39.815902709961): SELECT name FROM jos_deeppockets WHERE id=212
138 (29.087066650391): SELECT name FROM jos_deeppockets WHERE id=212
139 (854.0153503418): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
140 (754.11796569824): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
142 (516.89147949219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
143 (!!!!! 11854.887008667): TRUNCATE TABLE jos_trademed_module
144 (165.93933105469): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294738207 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
145 (87.02278137207): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294738207 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (915.0505065918): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
147 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
149 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
150 (!!!!! 1220.9415435791): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
151 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
152 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
153 (39.100646972656): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294738207 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294738207 AND type='deeppockets_item' AND published='1' LIMIT 1
154 (33.140182495117): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)
155 (30.994415283203): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)
156 (32.186508178711): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
157 (130.89179992676): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
158 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738207 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738207 AND published='1' LIMIT 1
159 (38.14697265625): select jos_twitters.link from jos_twitters where cat=10
160 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10
161 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10
162 (30.994415283203): select jos_linkedin.link from jos_linkedin where cat=10
163 (313.04359436035): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)
164 (!!!!! 1092.1955108643): insert into jos_banners_delta values (14615,'2025-06-21 19:29:22','216.73.216.120','view'),(14202,'2025-06-21 19:29:22','216.73.216.120','view'),(14203,'2025-06-21 19:29:22','216.73.216.120','view')