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Imaging Shows Developmental Disorders in the Brain Leading to Autism

By MedImaging International staff writers
Posted on 15 Nov 2011

Researchers have found a possible explanation for why autistic children act and think differently than their peers. For the first time, they have shown that the connections between brain regions that are important for language and social skills grow much more slowly in boys with autism than in nonautistic children.

Researchers from the University of California, Los Angeles (UCLA; USA) have found a possible reason autistic children think and act differently than their peers. For the first time, they have shown that the connections between brain regions that are important for language and social skills grow much more slowly in boys with autism than in nonautistic children.

Reporting in October 20, 2011, online edition of the journal Human Brain Mapping, senior author Jennifer G. Levitt, a professor of psychiatry at the Semel Institute for Neuroscience and Human Behavior at UCLA; first author Xua Hua, a UCLA postdoctoral researcher; and colleagues found aberrant growth rates in areas of the brain implicated in the social impairment, communication deficits, and repetitive behaviors that characterize autism.

Autism is believed to affect one in 110 children in the United States alone, and many specialists experts believe the numbers are growing. In spite of its prevalence, little is known about the disorder, and no cure has been discovered. Typically, as children grow into teenagers, the brain undergoes major changes. This highly dynamic process depends on the creation of new connections, called white matter, and the elimination, or “pruning,” of unused brain cells, called gray matter. As a result, our brains work out the ideal and most efficient ways to understand and respond to the world around us.
Although most children with autism are diagnosed before they are three years old, this new study suggests that delays in brain development continue into adolescence. “Because the brain of a child with autism develops more slowly during this critical period of life, these children may have an especially difficult time struggling to establish personal identity, develop social interactions, and refine emotional skills,” Dr. Hua said. “This new knowledge may help to explain some of the symptoms of autism and could improve future treatment options.”

The researchers used a type of brain-imaging scan called a T1-weighted magnetic resonance imaging (MRI), which can map structural changes during brain development. To evaluate how the brains of boys with autism altered over time, they scanned 13 boys diagnosed with autism and a control group of seven nonautistic boys on two separate occasions. The boys ranged in age from 6 to 14 at the time of the first scan; on average, they were scanned again about three years later. By scanning the boys twice, the scientists were able to create a detailed image of how the brain changes during this critical period of development.

In addition to seeing that the white-matter connections between those brain regions that are critical for language and social skills were growing much slower in the boys with autism, they discovered a second anomaly in two regions of the brain: in the putamen and the anterior cingulate unused cells were not correctly trimmed away.

“Together, this creates unusual brain circuits, with cells that are overly connected to their close neighbors and under-connected to important cells further away, making it difficult for the brain to process information in a normal way,” Dr. Hua said. “The brain regions where growth rates were found to be the most altered were associated with the problems autistic children most often struggle with--social impairment, communication deficits, and repetitive behavior.”

Future studies using alternative neuroscience techniques should attempt to identify the source of this white-matter impairment, according to the researchers. “This study provides a new understanding of how the brains of children with autism are growing and developing in a unique way,” Dr. Levitt said. “Brain imaging could be used to determine if treatments are successful at addressing the biological difference. The delayed brain growth in autism may also suggest a different approach for educational intervention in adolescent and adult patients, since we now know their brains are wired differently to perceive information.”

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58 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

59 (138.99803161621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

60 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

61 (126.12342834473): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (555.99212646484): SELECT fid FROM jos_deeppockets WHERE id=294738022 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294738022 AND published='1' LIMIT 1

63 (383.13865661621): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (56.982040405273): select jos_twitters.link from jos_twitters where cat=10

65 (30.040740966797): select jos_facebook.link from jos_facebook where cat=10

66 (36.954879760742): select jos_google_plus.link from jos_google_plus where cat=10

67 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

68 (47.922134399414): SELECT fid FROM jos_deeppockets WHERE id=294738022 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294738022 AND published='1' LIMIT 1

69 (49.829483032227): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (308.99047851562): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294738022 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (262.97569274902): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294738022 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (51.021575927734): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (61.988830566406): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.98762512207): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (51.021575927734): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294738022 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (29.087066650391): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294738022 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (32.901763916016): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (52.213668823242): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (59.127807617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

105 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

106 (60.081481933594): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294738022 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (48.87580871582): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294738022 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (69.141387939453): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

109 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

110 (49.114227294922): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294738022 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (577.92663574219): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294738022 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (660.89630126953): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (401.02005004883): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (252.00843811035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

115 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

116 (166.89300537109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

117 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

118 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

119 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

120 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

121 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

122 (360.01205444336): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 28318.166732788): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 1100.0633239746): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294738022 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294738022 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 19811.868667603): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (146.86584472656): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (!!!!! 1993.1793212891): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (55.074691772461): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (82.969665527344): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (381.9465637207): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (43.869018554688): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (27.894973754883): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (496.86431884766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (327.11029052734): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (180.95970153809): SELECT name FROM jos_deeppockets WHERE id=212

138 (42.915344238281): SELECT name FROM jos_deeppockets WHERE id=212

139 (690.93704223633): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (674.96299743652): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (94.175338745117): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

142 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

143 (!!!!! 10622.978210449): TRUNCATE TABLE jos_trademed_module

144 (136.13700866699): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294738022 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (74.863433837891): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294738022 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (645.87593078613): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (107.0499420166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

149 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

150 (!!!!! 1580.9535980225): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

152 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

153 (54.121017456055): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294738022 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294738022 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (46.014785766602): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (39.815902709961): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (48.87580871582): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (194.07272338867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

158 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294738022 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294738022 AND published='1' LIMIT 1

159 (72.002410888672): select jos_twitters.link from jos_twitters where cat=10

160 (41.961669921875): select jos_facebook.link from jos_facebook where cat=10

161 (39.815902709961): select jos_google_plus.link from jos_google_plus where cat=10

162 (239.13383483887): select jos_linkedin.link from jos_linkedin where cat=10

163 (438.92860412598): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 2187.0136260986): insert into jos_banners_delta values (14615,'2025-06-26 18:25:39','216.73.216.249','view'),(14202,'2025-06-26 18:25:39','216.73.216.249','view'),(14203,'2025-06-26 18:25:39','216.73.216.249','view')

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