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Brain Imaging Can Advance Alzheimer’s Disease Research

By MedImaging International staff writers
Posted on 03 Nov 2011

New findings distinctly reveal that multiple imaging systems are now available to help understand, diagnose, and treat Alzheimer’s disease.

The research was reported in the October 2011 supplement of the Journal of Alzheimer’s Disease, Imaging the Alzheimer Brain. “Alzheimer’s disease is now seen as a continuum that is influenced by factors early in life, including genetics and education,” according to guest editor J. Wesson Ashford, MD, PhD, clinical professor and senior research scientist at the Stanford/VA Alzheimer Center (Palo Alto, CA, USA). “Conceptualizing the continuum of AD with advanced imaging technology will provide a greater understanding of the disease, and help advance diagnosis and the quest for prevention and treatment.”

The supplement contains both reviews of the basic concepts of neuroimaging in the context of AD, the latest developments in imaging, and insights into: pathology and pathophysiologic bases of AD; structural and cerebral blood flow imaging; metabolism, amyloid plaques, and neurofibrillary tangles in vascular comorbidity and AD; current advances in functional magnetic resonance imaging for detecting AD; electromagnetic brain mapping; diffusion tensor imaging; magnetic resonance (MR) spectroscopy; and longitudinal neuroimaging measures.

Investigators have utilized brain imaging to track some of the earliest changes associated with the predisposition to AD. In their article, a group of scientists proposes to evaluate research treatments in healthy individuals who, based on their age and genetic background, are at the highest imminent risk of developing symptomatic AD. “It currently takes too many average healthy people, too much money, and too many years to evaluate the range of promising presymptomatic treatments using clinical endpoints,” said lead author Eric M. Raiman, of the Banner Alzheimer’s Institute (Phoenix, AZ, USA) and the University of Arizona (Tucson, USA). The project will use brain imaging studies, cerebrospinal fluid biomarkers, and cognitive measures to assess AD-modifying treatments earlier than is otherwise possible and to determine the degree to which the treatment’s brain imaging and other biomarker effects predict a clinical benefit, among other outcomes.

Dr. Ashford commented, “Even when imaging data are not applied to the management of individual patients, these data have the potential to assist in evaluating other components of care and diagnosis. To the extent that imaging can more sensitively measure brain integrity than existing techniques, novel treatments may be discovered because beneficial effects of treatments are not detectable with other methods.”

Two articles in the supplement provide fascinating insights into the association between cortical thinning and AD. In another study, researchers from the department of Veterans Affairs Medical Center, San Francisco, the University of California (UCSF) and the Hospital of the University of Pennsylvania (Philadelphia, USA) examined the relationship between rates of regional brain cortex thinning and reduced amyloid (Ab1-42) and higher tau concentrations. Using data from the Alzheimer’s Disease Neuroimaging Initiative, they discovered that these biomarkers were tied to increased rates of brain tissue loss, and that the patterns varied across the healthy elderly and the mildly cognitively impaired. “The finding of faster progression of brain atrophy in the presence of lower Ab1-42 levels and higher p-tau levels supports the hypothesis that they are measures of early AD pathology,” stated lead author Dr. Duygu Tosun.

It is well known that the presence of an ApoE e4 (e4+) allele increases the risk of developing AD. There is an adverse relationship between e4+ status and brain structure and function in mild cognitive impairment; the presence of an e2 allele may be protective. In another study, researchers examined whether the brain cortex thinning is the result of the disease, or a preexisting endophenotype. Drawing on imaging data from a large US sample, the study examined the influence of ApoE on regional brain thickness and structure. The presence of the e4+ revealed considerably thinner cortex in the frontal areas, and may clarify susceptibility to AD. The presence of the e2 allele was related to thicker cortex, suggesting a protective role.

In all, 31 articles discussed the developments in numerous imaging methodologies that are being used to increase our understanding of the pathophysiologic basis of AD and drive physicians toward new therapies for this complicated brain disorder. “Ultimately, the prospects for neuroimaging to enhance clinical care in Alzheimer’s disease are bright as researchers collaborate and clinicians become informed about innovations and advances,” noted George Perry, PhD, editor-in-chief, Journal of Alzheimer’s Disease, and dean and professor, College of Sciences, University of Texas at San Antonio (SA).

Related Links:
Stanford/VA Alzheimer Center
Banner Alzheimer’s Institute
Veterans Affairs Medical Center, San Francisco, the University of California

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52 (135.18333435059): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

53 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

54 (423.90823364258): SELECT name FROM jos_deeppockets WHERE id=294737875 LIMIT 1

55 (215.05355834961): SELECT name FROM jos_deeppockets_archive WHERE id=294737875 LIMIT 1

56 (84.877014160156): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'

57 (77.009201049805): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737875 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

58 (483.98971557617): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737875 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (!!!!! 1656.0554504395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

60 (108.95729064941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

61 (151.8726348877): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

62 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

63 (154.01840209961): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (694.99015808105): SELECT fid FROM jos_deeppockets WHERE id=294737875 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294737875 AND published='1' LIMIT 1

65 (64.13459777832): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

66 (77.962875366211): select jos_twitters.link from jos_twitters where cat=10

67 (46.014785766602): select jos_facebook.link from jos_facebook where cat=10

68 (43.869018554688): select jos_google_plus.link from jos_google_plus where cat=10

69 (45.061111450195): select jos_linkedin.link from jos_linkedin where cat=10

70 (51.975250244141): SELECT fid FROM jos_deeppockets WHERE id=294737875 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294737875 AND published='1' LIMIT 1

71 (52.928924560547): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

72 (478.98292541504): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294737875 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (324.96452331543): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294737875 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (61.988830566406): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (77.009201049805): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (42.200088500977): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (78.201293945312): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294737875 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (82.969665527344): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294737875 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (45.061111450195): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (66.041946411133): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (72.002410888672): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

107 (48.160552978516): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

108 (71.048736572266): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737875 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (47.922134399414): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737875 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (104.90417480469): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

111 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

112 (494.95697021484): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737875 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (480.17501831055): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737875 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (82.015991210938): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737874 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (545.97854614258): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737874 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (838.9949798584): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (625.8487701416): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (182.15179443359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

119 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

120 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

121 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

122 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

123 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

124 (65.803527832031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

125 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

126 (461.81678771973): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

127 (!!!!! 24002.075195312): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

128 (603.91426086426): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294737875 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294737875 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 8707.0465087891): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (123.02398681641): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (72.002410888672): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

132 (31.948089599609): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

133 (68.902969360352): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

134 (69.141387939453): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

135 (444.88906860352): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

136 (56.982040405273): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

137 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

138 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

139 (640.869140625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (461.10153198242): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (42.915344238281): SELECT name FROM jos_deeppockets WHERE id=212

142 (30.040740966797): SELECT name FROM jos_deeppockets WHERE id=212

143 (725.03089904785): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (620.84197998047): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

145 (90.837478637695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

146 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

147 (!!!!! 10941.028594971): TRUNCATE TABLE jos_trademed_module

148 (100.85105895996): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737875 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737875 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

150 (501.87110900879): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (58.889389038086): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

152 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

153 (68.187713623047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

154 (!!!!! 1250.9822845459): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

155 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

156 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

157 (63.896179199219): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294737875 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294737875 AND type='deeppockets_item' AND published='1' LIMIT 1

158 (47.922134399414): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

159 (45.061111450195): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

160 (72.002410888672): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

161 (161.88621520996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

162 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737875 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737875 AND published='1' LIMIT 1

163 (56.028366088867): select jos_twitters.link from jos_twitters where cat=10

164 (41.961669921875): select jos_facebook.link from jos_facebook where cat=10

165 (44.107437133789): select jos_google_plus.link from jos_google_plus where cat=10

166 (41.007995605469): select jos_linkedin.link from jos_linkedin where cat=10

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