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MRI Predicts Survival in Locally Advanced Rectal Cancer

By MedImaging International staff writers
Posted on 12 Sep 2011
A new study has shown that magnetic resonance imaging (MRI) used to assess responses to presurgery (neoadjuvant) chemotherapy or radiation may predict survival among patients with advanced rectal cancer. The findings suggest that MRI-evaluated tumor responses to neoadjuvant therapy could help clinicians to plan their patients’ subsequent treatments better.

MRI prior to surgery could help in the management of patients in a number of ways, including offering more intense therapy or alternative chemotherapy to those patients who appear initially resistant to chemotherapy, or changing the surgical strategy.

“This is the first time that MRI has been shown to predict outcome for patients with rectal cancer who have completed initial chemoradiation therapy,” said lead author Gina Brown, MBBS, MD, consultant radiologist and honorary senior lecturer in the department of radiology at the Royal Marsden Hospital NHS (National Health Service) Trust (Sutton, UK). “MRI staging and reassessment of rectal cancers before and after chemoradiotherapy are not routinely done for all patients. We’ve shown that using MRI this way can help change the course of patient care, perhaps enabling physicians to choose a more effective chemotherapy drug or even in some cases ultimately avoid surgery.”

In the trial called MERCURY (Measuring Effective Reductions in Cholesterol Using Rosuvastatin therapy), researchers used MRI to measure tumor shrinkage in 111 patients who had previously undergone preoperative radiotherapy or both chemotherapy and radiation (chemoradiation) for locally advanced rectal cancer. The group part of a larger study of MRI use in improving rectal cancer staging begun in 2002 was followed for five years. The researchers measured tumor response in terms of tumor regression grade [TRG], which measures the degree of tumor shrinkage after therapy, and the involvement of circumferential resection margin (CRM), which refers to the remaining cancer at the tumor edges after treatment, or predicted to remain after surgery. Patients were broadly designated either a “good” or “poor” responder to chemoradiation, according to MRI, and researchers compared survival of the two groups.

Investigators discovered that 72% of good responders to chemotherapy/radiation were alive after five years compared to 27 % of those who were poor responders. The disease-free survival for those with good responses was 64% versus 31% for the poor responders. Moreover, local recurrence rates at five years for those patients for whom there was MRI-predicted CRM involvement was 28% compared to 12% for patients with predicted cancer-free tumor margins.

Rectal cancer is typically found in advanced stages, and as a result, neoadjuvant chemoradiation is frequently given to try to shrink tumors and make them easier to remove. While surgeons attempt to completely remove the cancer in order to minimize the chances of cancer returning, advanced tumors are more difficult to completely remove and more likely to have unseen cancer remaining at the edges of tissue at the surgery site. A positive surgical margin (tumor that remains at the borders of the surgical resection) is considered a strong predictor of local recurrence.

Of the 111 patients in the study, 73% (81 patients) were expected to have cancer left in the surgical margins prior to initial treatment. After neoadjuvant therapy, only 42% (47 patients) were predicted to have disease left in the surgery margins, meaning this group was still at risk for recurrence prior to surgery.

“The next step is to take these tumor response grades and decide what the best treatment approach could be based on the degree of responses,” Dr. Brown said. She noted that future trials investigating neoadjuvant chemotherapy followed by chemoradiotherapy might be able to identify a subgroup of patients that has a good response and for whom chemotherapy alone might be enough, while also identifying those who needed further therapy prior to surgery. In some instance, the preoperative treatment removed all evidence of the tumor, leading some physicians to question the need for surgery.

The investigators have started a trial to study what occurs to those individuals who appear to not have any remaining cancer with chemoradiation alone and have deferred surgery. In some cases, this has resulted in long-term deferral with anal sphincter preservation. Other trials may also be designed to use MRI results in regard to treatment efficacy.

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87 (68.902969360352): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294737021 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
88 (41.007995605469): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294737021 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
89 (48.87580871582): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`
90 (76.055526733398): SELECT show_live FROM jos_com_show_setting LIMIT 1
91 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1
92 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1
93 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1
94 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1
95 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1
96 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1
97 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1
98 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1
99 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1
100 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1
101 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1
102 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1
103 (56.982040405273): SELECT show_live FROM jos_com_show_setting LIMIT 1
104 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
105 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
106 (82.969665527344): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737021 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
107 (252.96211242676): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737021 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
108 (107.0499420166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
109 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
110 (62.942504882812): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737021 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
111 (694.99015808105): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294737021 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
112 (803.94744873047): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
113 (703.09638977051): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1
114 (114.91775512695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
115 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
116 (84.161758422852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
117 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
118 (65.803527832031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
119 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
120 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
121 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
122 (524.99771118164): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`
123 (!!!!! 49424.171447754): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7
124 (642.77648925781): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294737021 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294737021 AND type='deeppockets_item' AND published='1' LIMIT 1
125 (!!!!! 10761.022567749): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
126 (132.08389282227): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3
127 (55.074691772461): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
128 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1
129 (59.127807617188): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
130 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1
131 (416.99409484863): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
132 (57.93571472168): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1
133 (53.167343139648): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
134 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1
135 (557.89947509766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
136 (432.01446533203): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
137 (300.16899108887): SELECT name FROM jos_deeppockets WHERE id=212
138 (46.014785766602): SELECT name FROM jos_deeppockets WHERE id=212
139 (748.1575012207): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
140 (635.14709472656): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3
141 (96.797943115234): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
142 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
143 (!!!!! 9961.1282348633): TRUNCATE TABLE jos_trademed_module
144 (135.18333435059): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737021 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
145 (82.015991210938): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294737021 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1
146 (!!!!! 1287.9371643066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
147 (79.870223999023): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1
148 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
149 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
150 (!!!!! 1682.9967498779): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6
151 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
152 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
153 (52.928924560547): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294737021 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294737021 AND type='deeppockets_item' AND published='1' LIMIT 1
154 (46.968460083008): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)
155 (41.961669921875): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)
156 (51.021575927734): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1
157 (180.00602722168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
158 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294737021 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294737021 AND published='1' LIMIT 1
159 (51.975250244141): select jos_twitters.link from jos_twitters where cat=10
160 (38.14697265625): select jos_facebook.link from jos_facebook where cat=10
161 (37.908554077148): select jos_google_plus.link from jos_google_plus where cat=10
162 (38.14697265625): select jos_linkedin.link from jos_linkedin where cat=10
163 (360.01205444336): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)
164 (!!!!! 1241.92237854): insert into jos_banners_delta values (14615,'2025-06-26 22:25:00','216.73.216.249','view'),(14202,'2025-06-26 22:25:00','216.73.216.249','view'),(14203,'2025-06-26 22:25:00','216.73.216.249','view')