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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

MRI Techniques Can Detect Key Markers of Early Osteoarthritis

By MedImaging International staff writers
Posted on 22 Aug 2011

Researchers have found that sophisticated magnetic resonance imaging (MRI) techniques can be used to detect slight changes in joint cartilage microstructure and provide physicians a diagnostic tool for finding key markers of early osteoarthritis (OA). By using these methods during patient exams to identify OA earlier, clinicians can shift the management of the disease from eventual joint reconstruction to long-term preservation.

The study’s findings were published in the July 2011 issue of the Journal of the American Academy of Orthopaedic Surgeons. “Imaging technology is now sensitive and powerful enough to enable detection of subtle changes in the intricate balance of water, chondrocytes and the collagen fibers and protein molecules that make up our joint cartilage which we now know can point to future osteoarthritis,” stated Laith Jazrawi, MD, associate professor of orthopedic surgery from New York University (NYU) Langone Medical Center (New York, NY, USA) and lead author of the study. “With an active and aging baby boomer population beginning to experience joint pain associated with age, we think there is great potential for bringing these imaging techniques from the lab to the benefit of patients.”

The clinical practice standard is to use traditional MRI imaging to evaluate the quality of cartilage in patients with joint pain, or known arthritis, which focuses on the morphologic integrity of the cartilage. In the laboratory, however, radiologists, orthopedic surgeons, and rheumatologists working as a team have used advances in MRI technology and biochemical imaging techniques to assess cartilage damaged by osteoarthritis. Damaged cartilage revealed distinct alterations in the concentration of water and collagen molecules, the micro- and macrostructure of collagen, and the concentrations of particular proteins, glycosoaminoglycans. The findings validate the use of these MRI techniques in the evaluation of younger patients with joint pain to identify the beginnings of OA allowing for earlier treatment to halt the progression of the disease.

“The development and optimization of these innovative MR techniques has opened up a new window into the understanding and possible treatment of arthritis before irreversible structural and morphological changes has occurred,” said Michael P. Recht, MD, a professor of radiology and chairman of the department of radiology.

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66 (32.186508178711): select jos_google_plus.link from jos_google_plus where cat=10

67 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

68 (31.948089599609): SELECT fid FROM jos_deeppockets WHERE id=294736696 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294736696 AND published='1' LIMIT 1

69 (31.948089599609): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (227.21290588379): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294736696 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (216.00723266602): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294736696 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (46.014785766602): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (130.89179992676): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (74.148178100586): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (49.114227294922): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (74.863433837891): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294736696 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (44.822692871094): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294736696 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (49.829483032227): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (62.942504882812): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (70.810317993164): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (40.769577026367): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (79.870223999023): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (102.99682617188): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

105 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

106 (49.829483032227): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294736696 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294736696 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

109 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

110 (48.87580871582): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294736696 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (549.0779876709): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294736696 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (532.86552429199): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (315.18936157227): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

115 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

116 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

117 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

118 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

119 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

120 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

121 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

122 (338.07754516602): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 20725.011825562): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (467.77725219727): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294736696 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294736696 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 9536.0279083252): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (118.97087097168): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (297.06954956055): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (220.06034851074): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (38.14697265625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (187.15858459473): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (61.03515625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (183.8207244873): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (33.140182495117): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (566.00570678711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (385.99967956543): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (367.87986755371): SELECT name FROM jos_deeppockets WHERE id=212

138 (35.04753112793): SELECT name FROM jos_deeppockets WHERE id=212

139 (617.98095703125): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (463.96255493164): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

142 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

143 (!!!!! 8949.9950408936): TRUNCATE TABLE jos_trademed_module

144 (106.8115234375): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294736696 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (66.041946411133): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294736696 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (872.85041809082): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

149 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

150 (!!!!! 1216.8884277344): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

152 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

153 (61.03515625): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294736696 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294736696 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (48.160552978516): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (41.961669921875): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (55.074691772461): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (90.837478637695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

158 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294736696 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294736696 AND published='1' LIMIT 1

159 (128.98445129395): select jos_twitters.link from jos_twitters where cat=10

160 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

161 (30.994415283203): select jos_google_plus.link from jos_google_plus where cat=10

162 (25.98762512207): select jos_linkedin.link from jos_linkedin where cat=10

163 (309.94415283203): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1058.1016540527): insert into jos_banners_delta values (14615,'2025-06-26 22:45:35','216.73.216.249','view'),(14202,'2025-06-26 22:45:35','216.73.216.249','view'),(14203,'2025-06-26 22:45:35','216.73.216.249','view')

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