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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Alzheimer's-Like Brain Alterations Seen in Cognitively Normal Elderly with Amyloid Plaques

By MedImaging International staff writers
Posted on 20 Apr 2011

Researchers using two brain-imaging modalities have discovered that seemingly normal older individuals with brain deposits of amyloid beta--the key component of the plaques found in the brains of Alzheimer's disease (AD) patients--also had changes in brain structure similar to those seen in AD patients. Findings of this study may help identify individuals who could be candidates for therapies to prevent the development of dementia.

The study's findings have received early online publication in April 2011 in the journal Annals of Neurology. "Our findings support the theory that Alzheimer's disease begins many years before symptoms appear and that amyloid plaque is an early sign of this process,” said Keith Johnson, MD, Massachusetts General Hospital (MGH; Boston, MA, USA) Imaging, senior author of the study. "We see that when amyloid deposits are present, even in cognitively normal individuals, the degenerative changes of Alzheimer's are underway. Long-term studies to track these changes and observe how they evolve are ongoing.”

Definitive diagnosis of AD requires finding amyloid plaques and neurofibrillary tangles in the brain at autopsy. In recent years, it has been possible to detect amyloid in living brains by positron emission tomography (PET) scanning with an imaging agent known as Pittsburgh compound B (PiB). Plaques have been seen in the brains of seemingly healthy individuals, as well as those with dementia, but whether the presence of plaques indicates the early stages of AD is not yet known.

High-resolution magnetic resonance imaging (MRI) studies have identified characteristic alterations in brain structure--thinning of key cortical regions and reduced volume of structures such as the hippocampus--in individuals with mild cognitive impairment, in individuals known to carry gene mutations that directly cause AD, and in diagnosed Alzheimer's patients. A recent study reported similar brain changes in some cognitively normal elderly but did not differentiate those who had amyloid deposits from those who did not.

The current study involved 87 cognitively normal older individuals and 32 patients diagnosed with mild Alzheimer's--correlated for age, gender, and education--who had enrolled in the long-term Harvard Aging Brain Study. Participants underwent both high-resolution MR imaging of brain structure and PET scanning with PiB to detect amyloid plaques. The findings revealed that those cognitively normal individuals who had amyloid plaques also had structural alterations similar to but less evident than the neurodegenerative changes seen in the symptomatic patients. Structural changes were most pronounced in regions comprising what is called the default network, which is known to be affected early in the course of AD.

"If amyloidosis--deposits of amyloid plaques--in the brains of clinically normal people is associated with Alzheimer's-like neurodegeneration, then amyloidosis itself may signify ‘preclinical' AD,” said Dr. Johnson, an associate professor of radiology at Harvard Medical School (Boston, MA, USA). "We need to learn more about how long it takes a normal person with amyloid to develop AD, whether there are critical ‘second hit' factors that convert amyloidosis to Alzheimer's disease, and if there are measures that can halt the process of neurodegeneration.”

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59 (!!!!! 3910.0646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

60 (490.90385437012): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

61 (604.15267944336): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (!!!!! 1579.9999237061): SELECT fid FROM jos_deeppockets WHERE id=294734594 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294734594 AND published='1' LIMIT 1

63 (125.88500976562): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (76.055526733398): select jos_twitters.link from jos_twitters where cat=10

65 (40.054321289062): select jos_facebook.link from jos_facebook where cat=10

66 (41.007995605469): select jos_google_plus.link from jos_google_plus where cat=10

67 (823.02093505859): select jos_linkedin.link from jos_linkedin where cat=10

68 (452.04162597656): SELECT fid FROM jos_deeppockets WHERE id=294734594 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294734594 AND published='1' LIMIT 1

69 (!!!!! 1343.9655303955): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (!!!!! 2025.842666626): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734594 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (355.95893859863): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734594 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (71.048736572266): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (920.05729675293): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (70.095062255859): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (334.9781036377): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (297.06954956055): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (254.86946105957): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (105.14259338379): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (!!!!! 1082.8971862793): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 1167.0589447021): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734594 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (509.02366638184): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734594 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (!!!!! 2185.1062774658): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (102.99682617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (443.93539428711): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (!!!!! 3973.9608764648): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (175.95291137695): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (115.87142944336): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (164.03198242188): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (624.8950958252): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (129.22286987305): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (272.03559875488): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (51.021575927734): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (!!!!! 1152.9922485352): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (130.89179992676): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (!!!!! 2568.0065155029): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (251.05476379395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

105 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

106 (!!!!! 4374.0272521973): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734594 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (!!!!! 1173.9730834961): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734594 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 5614.0422821045): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

109 (864.98260498047): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

110 (239.84909057617): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294734594 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (630.14030456543): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294734594 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (771.04568481445): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (562.90626525879): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (164.98565673828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

115 (128.03077697754): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

116 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

117 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

118 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

119 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

120 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

121 (57.93571472168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

122 (356.91261291504): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 82165.956497192): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 3246.0689544678): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734594 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734594 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 40150.165557861): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (!!!!! 24031.162261963): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (575.06561279297): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (208.13941955566): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (247.95532226562): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (240.80276489258): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (219.82192993164): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (204.08630371094): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (211.00044250488): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (181.91337585449): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (526.18980407715): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (342.84591674805): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (69.141387939453): SELECT name FROM jos_deeppockets WHERE id=212

138 (46.014785766602): SELECT name FROM jos_deeppockets WHERE id=212

139 (760.07843017578): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (779.86717224121): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (129.22286987305): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

142 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

143 (!!!!! 23371.934890747): TRUNCATE TABLE jos_trademed_module

144 (!!!!! 1813.8885498047): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734594 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (196.93374633789): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734594 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (556.94580078125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (83.92333984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (101.08947753906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

149 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

150 (!!!!! 5319.1184997559): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (116.82510375977): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

152 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

153 (61.988830566406): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734594 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734594 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (42.200088500977): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (70.810317993164): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (76.055526733398): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (175.95291137695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

158 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734594 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734594 AND published='1' LIMIT 1

159 (!!!!! 4142.9996490479): select jos_twitters.link from jos_twitters where cat=10

160 (108.00361633301): select jos_facebook.link from jos_facebook where cat=10

161 (43.869018554688): select jos_google_plus.link from jos_google_plus where cat=10

162 (37.908554077148): select jos_linkedin.link from jos_linkedin where cat=10

163 (369.78721618652): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1229.7630310059): insert into jos_banners_delta values (14615,'2025-06-27 12:13:14','216.73.216.249','view'),(14202,'2025-06-27 12:13:14','216.73.216.249','view'),(14203,'2025-06-27 12:13:14','216.73.216.249','view')

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