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MRI May Help Predict Which Adults Will Develop Alzheimer's

By MedImaging International staff writers
Posted on 19 Apr 2011

Using magnetic resonance imaging (MRI), researchers may be able to predict which adults with mild cognitive impairment are more likely to progress to Alzheimer's disease (AD).

The study findings were published online in the April 2011 issue of the journal Radiology. Mild cognitive impairment (MCI) is an intermediate stage between the decline in mental abilities that occurs in normal aging and the more pronounced deterioration associated with dementia, a group of brain disorders that includes AD.

Individuals with MCI develop AD at a rate of 15%-20% per year, which is considerably higher than the 1%-2% rate for the general population. Some individuals with MCI remain stable while others gradually decline and some quickly deteriorate. "Being able to better predict which individuals with MCI are at greatest risk for developing Alzheimer's would provide critical information if disease-modifying therapies become available,” said the study's lead author, Linda K. McEvoy, PhD, assistant professor in the department of radiology at the University of California, San Diego School of Medicine (USA).

Dr. McEvoy and a team of researchers analyzed MRI exams from the Alzheimer's Disease Neuroimaging Initiative (ADNI), a large publicly and privately sponsored study, which performed imaging and other tests on hundreds of healthy individuals and others with MCI and early AD between 2005 and 2010 in hopes of identifying valuable biomarkers of the disease process.

Included in the study were a baseline MRI scan, serving as an initial point of measurement, and a second MRI performed a year later on 203 healthy adults, 317 patients with MCI and 164 patients with late-onset AD. The average age of the study participants was 75.

Utilizing MRI, the researchers measured the thickness of the cerebral cortex and observed the pattern of thinning to compute a risk score. One of the characteristics of AD is a loss of brain cells, called atrophy, in specific areas of the cortex. "MRI is very sensitive to brain atrophy,” Dr. McEvoy said. "There's a pattern of cortical thinning associated with AD that indicates the patient is more likely to progress to AD.”

Using the baseline MRI, the researchers calculated that the patients with MCI had a one-year risk of conversion to AD ranging from 3% to 40%. "Compared to estimating a patient's risk of conversion based on a clinical diagnosis only, MRI provides substantially more informative, patient-specific risk estimates,” Dr. McEvoy noted. "The baseline MRI helped identify which patients were at very low risk of progressing to Alzheimer's and those whose risk was doubled.”

By integrating the findings of the baseline MRI and the MRI scan performed one year later, the researchers were able to calculate a rate of change in brain atrophy that was even more informative. The MCI patients' risk of disease progression based on the serial MR exams ranged from 3%-69%. "Rapid thinning of the cortex is reflective of a degenerative disorder,” Dr. McEvoy explained.

Although no treatments now exist that slow or prevent the neurodegeneration associated with AD, Dr. McEvoy reported that patients at high risk of progressing to AD might want to enroll in clinical trials of disease-modifying therapies. She stated that the information would also help ensure patients receive optimal care and allow families more time for planning.

Related Links:
University of California, San Diego School of Medicine

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60 (152.1110534668): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

61 (!!!!! 2939.9394989014): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (555.99212646484): SELECT fid FROM jos_deeppockets WHERE id=294734575 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294734575 AND published='1' LIMIT 1

63 (343.08433532715): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (450.84953308105): select jos_twitters.link from jos_twitters where cat=10

65 (242.23327636719): select jos_facebook.link from jos_facebook where cat=10

66 (58.174133300781): select jos_google_plus.link from jos_google_plus where cat=10

67 (421.04721069336): select jos_linkedin.link from jos_linkedin where cat=10

68 (573.87351989746): SELECT fid FROM jos_deeppockets WHERE id=294734575 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294734575 AND published='1' LIMIT 1

69 (334.9781036377): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (!!!!! 2800.9414672852): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734575 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (!!!!! 1727.819442749): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734575 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (55.074691772461): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (528.09715270996): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (164.98565673828): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (335.9317779541): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (91.075897216797): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (164.98565673828): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (102.99682617188): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (428.91502380371): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734575 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (344.99168395996): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734575 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (51.975250244141): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (!!!!! 3776.0734558105): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (!!!!! 1149.8928070068): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (!!!!! 2689.8384094238): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (169.99244689941): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (264.88304138184): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (180.95970153809): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (38.14697265625): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (416.04042053223): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (165.93933105469): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (190.01960754395): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

105 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

106 (!!!!! 1168.966293335): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734575 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (909.09004211426): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734575 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 1760.9596252441): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

109 (!!!!! 2377.0332336426): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

110 (181.91337585449): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294734575 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (522.13668823242): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294734575 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (760.07843017578): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (500.91743469238): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (154.97207641602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

115 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

116 (84.877014160156): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

117 (51.021575927734): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

118 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

119 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

120 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

121 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

122 (461.10153198242): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 65774.917602539): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (644.92225646973): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734575 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734575 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 116647.00508118): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (104.90417480469): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (598.90747070312): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (77.962875366211): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (221.01402282715): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (94.890594482422): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (177.86026000977): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (61.03515625): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (176.90658569336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (95.129013061523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (953.91273498535): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (699.04327392578): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (244.8558807373): SELECT name FROM jos_deeppockets WHERE id=212

138 (52.928924560547): SELECT name FROM jos_deeppockets WHERE id=212

139 (969.17152404785): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (731.9450378418): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (295.87745666504): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

142 (80.108642578125): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

143 (!!!!! 12392.044067383): TRUNCATE TABLE jos_trademed_module

144 (367.87986755371): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734575 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (230.07392883301): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734575 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (954.86640930176): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (195.98007202148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (123.97766113281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

149 (300.88424682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

150 (!!!!! 1569.9863433838): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (344.03800964355): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

152 (110.14938354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

153 (153.0647277832): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734575 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734575 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (92.983245849609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (42.915344238281): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (46.014785766602): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (!!!!! 1055.9558868408): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

158 (133.99124145508): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734575 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734575 AND published='1' LIMIT 1

159 (!!!!! 3248.929977417): select jos_twitters.link from jos_twitters where cat=10

160 (!!!!! 1369.9531555176): select jos_facebook.link from jos_facebook where cat=10

161 (51.021575927734): select jos_google_plus.link from jos_google_plus where cat=10

162 (41.007995605469): select jos_linkedin.link from jos_linkedin where cat=10

163 (409.84153747559): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1456.9759368896): insert into jos_banners_delta values (14615,'2025-06-27 12:13:14','216.73.216.249','view'),(14202,'2025-06-27 12:13:14','216.73.216.249','view'),(14203,'2025-06-27 12:13:14','216.73.216.249','view')

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