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Agent for Pancreatic MRI Shown to Improve Image Quality

By MedImaging International staff writers
Posted on 29 Mar 2011

Positive results from a phase-3 study to evaluate the safety and efficacy of RG1068, synthetic human secretin demonstrated improvement to magnetic resonance imaging (MRI) scans of the pancreas in patients with pancreatic disease using endoscopy (ERCP) as a diagnostic reference.

The study's coprimary endpoints were achievement of a statistically significant improvement in sensitivity of detection of abnormalities with a loss in specificity of less than 7.5% by two of the three central radiologists reading the MRI images. In this study, all three radiologists achieved a clinically and statistically significant improvement in sensitivity (all radiologists p < 0.0001) with minimal loss in specificity (all radiologists < 7.5%). Moreover, the RG1068-MRI images revealed highly significant improvements on image quality (all radiologists p < 0.0001) and confidence in the diagnostic findings (all radiologists p < 0.0001), when compared to MRI alone. There were no serious adverse events (SAEs) or unscheduled days of hospitalization associated with the RG1068-MRI procedures compared to 55 SAEs and 236 days of unscheduled hospitalization associated with the ERCP procedures.

"This study demonstrated that RG1068 improves the identification of patients with pancreatic disease and allows the radiologist to render a more highly confident diagnosis to the gastroenterologist,” stated Dr. Stuart Sherman, MD, professor of medicine and radiology at Indiana University School of Medicine (Indianapolis, USA) and clinical director of gastroenterology and hepatology, and the lead investigator of this study. "RG1068 has the potential to significantly increase a physician's ability to confidently triage their patients, to improve planning for indicated ERCP and pancreatic surgery and will be an important aid in avoiding unnecessary ERCP procedures which are potentially harmful for patients.”

"We are pleased with the strongly positive results of this study which support the use of RG1068-MRI as a safe, noninvasive approach to the identification of pancreatic abnormalities,” stated Walter C. Herlihy, president and chief executive officer of Repligen Corp. (Waltham, MA, USA), the manufacturer of the compound. "We intend to request a meeting with the FDA to review these results and to discuss our plan to file a New Drug Application [NDA].”

The study was a multicenter, baseline controlled, single dose evaluation in which 258 patients enrolled at 29 clinical sites within the United States and Canada received an MRI of the pancreas with and without RG1068, and separately an ERCP. The MRI images were randomized and independently reviewed by three radiologists for assessment of the presence or absence of 10 prespecified pancreatic duct abnormalities, image quality, visualization of the main pancreatic duct, and confidence in diagnostic results. The study's coprimary endpoints were an improvement in sensitivity of identification of structural abnormalities of the pancreatic ducts using RG1068 in combination with MRI in comparison to MRI alone with minimal loss in specificity (< 7.5%). The study design used ERCP as the diagnostic reference for determination of structural abnormalities.

The analysis of the phase-3 radiographic images was a "re-read,” which was agreed to by the US Food and Drug Administration (FDA) and European Medicines Agency based on the determination that the original analysis was flawed and therefore inconclusive due to deficiencies in performance by the contract research organization overseeing the original analysis. A new contract research organization and three new radiologists were hired to conduct the re-read.

RG1068, a synthetic version of human secretin, stimulates the secretion of pancreatic fluid into the pancreatic ducts, thereby filling the ducts with water, which improves the ability to visualize pancreatic abnormalities. Identification of pancreatic duct abnormalities is important in the identification of cause and potential treatment options for diseases such as pancreatitis.

The FDA has granted RG1068 Orphan Drug status and Fast Track Designation, a process designed to facilitate the development and accelerate the review of drugs that treat serious diseases and fill an unmet medical need based on the need for safer, noninvasive tests to diagnose pancreatic disorders. There are about 300,000 MRI procedures performed in the United States and Europe yearly that could directly benefit from the addition of RG1068.

Related Links:
Indiana University School of Medicine
Repligen

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57 (!!!!! 2810.9550476074): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

58 (!!!!! 2235.8894348145): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

59 (!!!!! 6709.8140716553): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

60 (!!!!! 3689.0506744385): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

61 (!!!!! 3355.0262451172): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (747.9190826416): SELECT fid FROM jos_deeppockets WHERE id=294734147 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294734147 AND published='1' LIMIT 1

63 (87.02278137207): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (!!!!! 2421.8559265137): select jos_twitters.link from jos_twitters where cat=10

65 (95.844268798828): select jos_facebook.link from jos_facebook where cat=10

66 (48.87580871582): select jos_google_plus.link from jos_google_plus where cat=10

67 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

68 (49.114227294922): SELECT fid FROM jos_deeppockets WHERE id=294734147 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294734147 AND published='1' LIMIT 1

69 (52.928924560547): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (535.01129150391): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734147 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (429.15344238281): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734147 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (71.048736572266): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (50.067901611328): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (112.05673217773): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (!!!!! 2670.7649230957): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (170.94612121582): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (107.0499420166): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (276.08871459961): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (!!!!! 2804.0409088135): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (!!!!! 5339.8609161377): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734147 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (44.822692871094): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734147 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (38.14697265625): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (971.07887268066): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 3079.1759490967): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

105 (129.93812561035): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

106 (!!!!! 3512.1440887451): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734147 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (655.17425537109): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734147 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 1061.2010955811): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

109 (!!!!! 1626.9683837891): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

110 (164.03198242188): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294734147 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (602.00691223145): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294734147 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (!!!!! 1336.8129730225): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (!!!!! 1411.9148254395): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (81.062316894531): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

115 (57.220458984375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

116 (138.99803161621): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

117 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

118 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

119 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

120 (59.843063354492): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

121 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

122 (365.01884460449): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 41473.150253296): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (573.15826416016): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734147 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734147 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 15883.922576904): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (63.896179199219): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (41.007995605469): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (66.041946411133): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (330.92498779297): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (33.855438232422): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (479.93659973145): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (332.11708068848): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (40.054321289062): SELECT name FROM jos_deeppockets WHERE id=212

138 (30.040740966797): SELECT name FROM jos_deeppockets WHERE id=212

139 (576.01928710938): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (456.09474182129): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (103.95050048828): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

142 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

143 (!!!!! 13775.110244751): TRUNCATE TABLE jos_trademed_module

144 (91.075897216797): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734147 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (913.85841369629): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294734147 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (971.07887268066): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

149 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

150 (!!!!! 1385.9272003174): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (!!!!! 1008.9874267578): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

152 (99.897384643555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

153 (49.829483032227): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294734147 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294734147 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (33.140182495117): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (29.802322387695): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (47.922134399414): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (205.99365234375): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

158 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294734147 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294734147 AND published='1' LIMIT 1

159 (!!!!! 3125.9059906006): select jos_twitters.link from jos_twitters where cat=10

160 (74.148178100586): select jos_facebook.link from jos_facebook where cat=10

161 (34.093856811523): select jos_google_plus.link from jos_google_plus where cat=10

162 (29.087066650391): select jos_linkedin.link from jos_linkedin where cat=10

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