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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

qMRI Reveals Disease-Modifying Effects of Chondroitin Sulfate in Knee Osteoarthritis

By MedImaging International staff writers
Posted on 18 Mar 2011

A group of Canadian researchers published findings from a clinical trial in which they confirmed, for the first time, using quantitative magnetic resonance imaging (qMRI), the disease-modifying effects of chondroitin sulfate, a symptomatic slow-acting drug for osteoarthritis (SYSADOA).

This clinical trial, published March 1, 2011, in the journal Annals of the Rheumatic Diseases (impact factor 8.111), explored the effect of chondroitin sulfate (CS) treatment on cartilage volume loss, subchondral bone marrow lesions (BMLs), and synovitis in patients with knee osteoarthritis (OA). "This study focused on quantifying over time by MRI the main structural changes observed in the cartilage, bone and synovial membrane,” stated Jean-Pierre Pelletier, MD, professor of medicine and head of the osteoarthritis research unit at the University of Montreal Hospital Research Center (Canada).

The investigator stated that after only six months of treatment with CS, patients showed a considerable decrease in loss of articular cartilage as compared to the placebo group, and for the first time, a significant reduction in the progression of BMLs by 12 months. According to Prof. Pelletier, these data highlight not only the importance of the interrelationship between cartilage and subchondral bone in OA, but also its potential role in the disease process and response to treatment with SYSADOAs.

Prof. Pelletier concluded that, "CS is a safe drug with an overall positive effect on OA, significantly reducing the volume of cartilage loss in knee OA, and providing for the first time new information on its positive effect in vivo on other structural changes observed in this disease.”

Prof. Pelletier commented that the clinical trial results prove that CS is able to slow the progression of OA; however, this does not mean it is able to cure. "The cure involves the regression of all lesions related to OA,” he noted, "and that's not the case. Chondroitin sulfate slows the progression of the disease. This is an important finding as a decrease in the rate of progression of cartilage loss in knee OA patients, as seen by MRI, could potentially reduce the need for total knee replacement a phenomenon that has been observed in other MRI clinical studies.”

Prof. Pelletier reported that the results of this pilot MRI study are very positive and encouraging. Given the validated efficacy and safety of the product, it represents a most valuable option for OA patients. Although he noted, "it is important that patients are provided with highly purified pharmaceutical grade CS, the one used in this study, as this is the only one that can guarantee such efficacy and specifically, safety results.”

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62 (674.96299743652): SELECT fid FROM jos_deeppockets WHERE id=294733896 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294733896 AND published='1' LIMIT 1

63 (480.17501831055): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (71.048736572266): select jos_twitters.link from jos_twitters where cat=10

65 (33.855438232422): select jos_facebook.link from jos_facebook where cat=10

66 (34.093856811523): select jos_google_plus.link from jos_google_plus where cat=10

67 (32.901763916016): select jos_linkedin.link from jos_linkedin where cat=10

68 (43.869018554688): SELECT fid FROM jos_deeppockets WHERE id=294733896 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294733896 AND published='1' LIMIT 1

69 (35.04753112793): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (353.09791564941): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733896 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (394.82116699219): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733896 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (72.002410888672): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (59.843063354492): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (62.942504882812): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (29.802322387695): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (52.928924560547): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733896 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (31.232833862305): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733896 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (33.855438232422): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (65.088272094727): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (63.896179199219): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

105 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

106 (52.928924560547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733896 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (57.93571472168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733896 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (79.154968261719): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

109 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

110 (51.975250244141): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294733896 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (498.05641174316): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294733896 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (675.20141601562): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (411.03363037109): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

115 (65.803527832031): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

116 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

117 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

118 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

119 (39.815902709961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

120 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

121 (39.815902709961): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

122 (339.03121948242): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 29052.019119263): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (746.9654083252): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733896 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733896 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 9813.0702972412): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (102.04315185547): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (72.002410888672): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (56.982040405273): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (108.95729064941): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (43.153762817383): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (473.97613525391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (54.836273193359): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (51.021575927734): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (44.107437133789): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (600.81481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (523.09036254883): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (291.82434082031): SELECT name FROM jos_deeppockets WHERE id=212

138 (43.869018554688): SELECT name FROM jos_deeppockets WHERE id=212

139 (816.10679626465): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (741.95861816406): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (123.97766113281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

142 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

143 (!!!!! 10755.062103271): TRUNCATE TABLE jos_trademed_module

144 (131.13021850586): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733896 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (73.909759521484): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733896 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (521.89826965332): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (87.976455688477): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (257.01522827148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

149 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

150 (!!!!! 1842.9756164551): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (125.88500976562): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

152 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

153 (75.101852416992): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733896 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733896 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (729.79927062988): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (57.93571472168): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (70.095062255859): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (96.08268737793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

158 (72.002410888672): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733896 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733896 AND published='1' LIMIT 1

159 (64.849853515625): select jos_twitters.link from jos_twitters where cat=10

160 (46.968460083008): select jos_facebook.link from jos_facebook where cat=10

161 (56.982040405273): select jos_google_plus.link from jos_google_plus where cat=10

162 (41.961669921875): select jos_linkedin.link from jos_linkedin where cat=10

163 (391.96014404297): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1447.9160308838): insert into jos_banners_delta values (14615,'2025-06-27 12:46:47','216.73.216.249','view'),(14202,'2025-06-27 12:46:47','216.73.216.249','view'),(14203,'2025-06-27 12:46:47','216.73.216.249','view')

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