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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Gadobutrol Injection for MRI of the Central Nervous System Approved for Use in the US

By MedImaging International staff writers
Posted on 23 Feb 2011

A magnetic resonance imaging (MRI) contrast agent called gadobutrol is formulated at a 1.0 molar concentration (mol/L) and was shown to provide a higher concentration (lower volume) compared to other contrast agents used for central nervous system (CNS) imaging.

Bayer HealthCare Pharmaceuticals, Inc. (Wayne, NJ, USA) announced that the Peripheral and Central Nervous System Drugs Advisory Committee to the US Food and Drug Administration (FDA; Silver Spring, MD, USA) voted unanimously that clinical trial and postmarketing data for gadobutrol injection, a macrocyclic 1.0 molar gadolinium-based contrast agent (GBCA), support approval of the product for proposed use in diagnostic MRI in adults and children (two years of age and older) to detect and visualize areas with disrupted blood brain barrier and/or abnormal vascularity of the CNS.

In addition to the vote for approval, Committee members concurred by a vote of 15 to 1 that gadobutrol should be labeled without a nephrogenic systemic fibrosis (NSF) contraindication in the at-risk population. NSF is a very rare but serious disease that affects a small percentage of patients with severe renal impairment who undergo contrast-enhanced MRI. All marketed GBCAs have a boxed warning about the potential for NSF in patients with chronic severe kidney disease or acute kidney injury.

The Bayer announcement further stated that Bayer appreciated the Committee's discussion and suggestions around risk minimization for inadvertent dose misadministration, and would continue to work with the FDA as it finalizes its review of gadobutrol. "Bayer is pleased that the Advisory Committee recognized the totality of the clinical and postmarketing data presented,” said Pamela A. Cyrus, MD, vice president and head of US Medical Affairs, Bayer HealthCare Pharmaceuticals. "If approved by the FDA, Bayer believes that gadobutrol will provide healthcare providers with an additional new option for CNS imaging in the United States.”

Data presented at the January 31, 2011, Advisory Committee meeting included results from two adequate and well-controlled phase 3 studies that confirmed the efficacy and safety of gadobutrol injection in contrast enhanced MRI of the CNS. Prospectively defined primary and secondary endpoints were met in the two studies. The first phase 3 study compared the efficacy of combined gadobutrol-enhanced images plus unenhanced images to unenhanced images alone. The second phase 3 study used a crossover design with an active control, gadoteridol, to also compare the efficacy of the combined gadobutrol-enhanced plus unenhanced images to unenhanced images alone, as well as to confirm noninferiority of combined gadobutrol imaging versus combined gadoteridol imaging.

The results of the first phase 3 study showed that gadobutrol-enhanced images compared to unenhanced images were superior in diagnostic performance and superior for the visualization variables, contrast enhancement, border delineation, and internal morphology. The findings for comparison of unenhanced images compared to gadobutrol-enhanced images were consistent across both phase 3 trials. In the second phase 3 study comparing gadobutrol-enhanced images to images enhanced with the approved contrast agent gadoteridol, gadobutrol was confirmed to be noninferior to gadoteridol with respect to visualization variables, contrast enhancement, border delineation, and internal morphology, as well as the number of lesions detected.

The most common adverse drug reactions observed in phase 2-4 trials for gadobutrol were generally consistent with those of other gadolinium based contrast agents. Across the studies (n = 4549), the most common adverse events (AEs) associated with gadobutrol were: headache (1.5%), nausea (1.2%), injection site reactions (0.6%), dysgeusia (0.5%), feeling hot (0.5%), dizziness (0.4%), vomiting (0.4%), rash (0.3%), pruritis (0.2%), erythema (0.2%), dyspnea (0.2%), and parasthesia (0.1%). During the entire clinical development program of gadobutrol, only isolated reports of serious adverse events were recorded. Overall, serious AEs (including fatal) were observed in 17 (0.4%) of 4,549 patients. One of the 17 serious AEs reported in the gadobutrol group was considered drug-related by the investigator (crystals in urine one day after injection).

The New Drug Application (NDA) for gadobutrol was submitted to the FDA on May 14, 2010. The Advisory Committee's recommendations are not binding, but FDA reviewers will consider the panel's recommendation in its final assessment of the NDA.

Bayer HealthCare Pharmaceuticals, Inc. is the US-based pharmaceuticals operation of Bayer HealthCare LLC, a division of Bayer, AG (Leverkusen, Germany).

Related Links:
Bayer HealthCare Pharmaceuticals
US Food and Drug Administration

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56 (376.93977355957): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733572 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

57 (!!!!! 1065.0157928467): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

58 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

59 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

60 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

61 (102.04315185547): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (627.99453735352): SELECT fid FROM jos_deeppockets WHERE id=294733572 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294733572 AND published='1' LIMIT 1

63 (65.088272094727): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (77.009201049805): select jos_twitters.link from jos_twitters where cat=10

65 (41.007995605469): select jos_facebook.link from jos_facebook where cat=10

66 (37.908554077148): select jos_google_plus.link from jos_google_plus where cat=10

67 (41.007995605469): select jos_linkedin.link from jos_linkedin where cat=10

68 (48.160552978516): SELECT fid FROM jos_deeppockets WHERE id=294733572 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294733572 AND published='1' LIMIT 1

69 (40.054321289062): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (415.08674621582): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733572 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (295.87745666504): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733572 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (56.028366088867): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (71.048736572266): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (42.200088500977): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (44.107437133789): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (82.015991210938): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (105.14259338379): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (64.849853515625): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733572 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (46.014785766602): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733572 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (51.975250244141): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (256.06155395508): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (492.09594726562): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (50.783157348633): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (94.175338745117): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (300.88424682617): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (349.04479980469): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (!!!!! 1164.9131774902): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (46.968460083008): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (39.815902709961): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (83.208084106445): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

105 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

106 (53.882598876953): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733572 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733572 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (!!!!! 3779.1728973389): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

109 (!!!!! 1863.956451416): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

110 (86.069107055664): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294733572 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (427.9613494873): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294733572 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (887.87078857422): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (763.1778717041): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (135.89859008789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

115 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

116 (93.936920166016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

117 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

118 (66.041946411133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

119 (53.167343139648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

120 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

121 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

122 (396.9669342041): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 29772.043228149): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (674.96299743652): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733572 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733572 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 10123.96812439): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (111.10305786133): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (66.041946411133): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (351.90582275391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (115.15617370605): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (42.915344238281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (513.79203796387): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (469.92301940918): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (52.928924560547): SELECT name FROM jos_deeppockets WHERE id=212

138 (36.001205444336): SELECT name FROM jos_deeppockets WHERE id=212

139 (776.05247497559): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (725.03089904785): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (115.87142944336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

142 (78.201293945312): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

143 (!!!!! 17889.976501465): TRUNCATE TABLE jos_trademed_module

144 (136.13700866699): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733572 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (80.82389831543): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733572 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (817.06047058105): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (108.00361633301): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

149 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

150 (!!!!! 2249.002456665): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

152 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

153 (82.969665527344): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733572 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733572 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (51.975250244141): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (41.961669921875): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (116.10984802246): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (180.00602722168): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

158 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733572 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733572 AND published='1' LIMIT 1

159 (71.048736572266): select jos_twitters.link from jos_twitters where cat=10

160 (30.994415283203): select jos_facebook.link from jos_facebook where cat=10

161 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

162 (30.040740966797): select jos_linkedin.link from jos_linkedin where cat=10

163 (478.02925109863): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 5340.8145904541): insert into jos_banners_delta values (14615,'2025-06-27 15:16:15','216.73.216.249','view'),(14202,'2025-06-27 15:16:15','216.73.216.249','view'),(14203,'2025-06-27 15:16:15','216.73.216.249','view')

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