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Collaboration to Measure, Visualize Local MR Drug Delivery to Tumors

By MedImaging International staff writers
Posted on 23 Feb 2011

A joint research team has now demonstrated in preclinical studies that an improved magnetic resonance (MR)-guided drug delivery technique in which local drug uptake in tumors is achieved, can be visualized and measured in real time. These measurements may provide an indication at time of delivery if drug uptake in the tumor was sufficient, or if an additional treatment may be needed.

The research collaboration was initiated by Philips Medical Systems (Best, The Netherlands) and Eindhoven University of Technology (TU/e; The Netherlands). Image-guided drug delivery has been studied by scientists all around the world for almost a decade because it may enable a beneficial increase in tumor chemotherapy drug levels, thereby increasing treatment efficacy without an increase in adverse side effects. This proof of concept research was published in the Journal of Controlled Release in February 2011.

Cancer chemotherapy treatment is used to kill tumor cells and is more effective at higher doses. However, the applicable dosage levels are limited by potentially severe adverse effects to the rest of the body. In preclinical studies using their local drug delivery proof-of-concept system designed for the treatment of specific types of tumors, Philips and TU/e achieved an increased chemotherapy drug dose at the tumor site. Some tumors contain sections poorly supplied with blood, which means that chemotherapy drugs are then not taken up evenly in the tumor. As a result, some regions receive suboptimal doses and they are therefore not effectively treated with chemotherapy. Methods for visualizing and measuring drug uptake in the tumor at time of delivery were demonstrated in the preclinical investigations. Such information may give an indication directly after the treatment if drug uptake was sufficient. Based on this additional information, tumors that did not receive a sufficient drug dose due to their morphology may be candidates to receive an alternative therapy.

The research was performed under the leadership of Holger Grüll, a professor in the biomedical nuclear magnetic resonance (NMR) research group at the Eindhoven University of Technology and responsible for research into molecular imaging and therapy at Philips Research. Philips and TU/e have been working together in this exploratory research, which is also part of the EU-funded (Framework 7) European Research project Sonodrugs, for two years. The study was performed in a designated joint infrastructure in Eindhoven. Prof. Grüll and his team used a combination of MRI and ultrasound technologies together with temperature sensitive drug-carrying particles (liposomes) for local chemotherapy drug delivery.

The liposomes, injected into the bloodstream, transport the drug around the body and to the tumor. The latter is mildly heated using a focused ultrasound beam causing the temperature-sensitive liposomes in the tumor to release their drug payload. Simultaneous MR imaging is used to locate the tumor, measure local tissue temperature, and guide the ultrasound heating. To track the amount of drug released, the liposomes also contain a clinically used MRI contrast agent, which is co-released on heating. The release of the contrast agent can be monitored with MRI, allowing correlated measurements and visualizations of drug uptake in the tumor and surrounding tissue.

The preclinical studies demonstrated proof-of-concept feasibility of the local drug delivery method and the measurement and visualization of drug release. Additional preclinical studies are currently being performed to evaluate the therapeutic value of the technique, which is the next necessary step for clinical translation towards a therapeutic application in patients.

"Image-guided drug delivery technology has the potential to improve chemotherapy cancer treatment for certain types of cancer,” commented Henk van Houten, senior vice president and general manager at Philips Research and program manager healthcare. "Researchers from the Philips-TU/e collaboration are among the leaders in developing the MRI, ultrasound, and liposome combination technology for local drug delivery. Collaborating with partners and building on Philips' strength in medical imaging, we have shown that early feedback at the time of localized drug delivery treatment is possible, which could ultimately enable more informed treatment planning for better patient outcomes.”

Related Links:
Philips Medical Systems
Eindhoven University of Technology

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57 (74.863433837891): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733554 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

58 (551.93901062012): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733554 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

59 (!!!!! 1614.0937805176): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

60 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

61 (118.01719665527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

62 (68.902969360352): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

63 (108.00361633301): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

64 (544.07119750977): SELECT fid FROM jos_deeppockets WHERE id=294733554 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294733554 AND published='1' LIMIT 1

65 (!!!!! 1808.8817596436): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

66 (69.141387939453): select jos_twitters.link from jos_twitters where cat=10

67 (39.815902709961): select jos_facebook.link from jos_facebook where cat=10

68 (40.054321289062): select jos_google_plus.link from jos_google_plus where cat=10

69 (35.04753112793): select jos_linkedin.link from jos_linkedin where cat=10

70 (45.7763671875): SELECT fid FROM jos_deeppockets WHERE id=294733554 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294733554 AND published='1' LIMIT 1

71 (42.915344238281): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

72 (408.88786315918): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733554 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

73 (355.00526428223): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733554 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

74 (54.121017456055): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

75 (76.055526733398): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (48.87580871582): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (66.995620727539): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (43.153762817383): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (64.13459777832): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733554 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

90 (30.994415283203): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733554 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

91 (36.001205444336): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

92 (60.081481933594): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (97.990036010742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

107 (62.942504882812): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

108 (72.002410888672): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733554 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

109 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733554 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

110 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

111 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

112 (604.15267944336): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294733554 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (621.08039855957): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294733554 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

114 (66.995620727539): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294733553 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

115 (422.95455932617): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294733553 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (656.1279296875): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

117 (347.85270690918): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

118 (92.029571533203): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

119 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

120 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

121 (121.11663818359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

122 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

123 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

124 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

125 (53.882598876953): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

126 (321.86508178711): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

127 (!!!!! 28103.113174438): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

128 (607.96737670898): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733554 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733554 AND type='deeppockets_item' AND published='1' LIMIT 1

129 (!!!!! 10200.977325439): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

130 (99.897384643555): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

131 (50.067901611328): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

132 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

133 (59.843063354492): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

134 (36.954879760742): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

135 (404.83474731445): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

136 (50.067901611328): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

137 (41.961669921875): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

138 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

139 (504.0168762207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

140 (387.90702819824): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

141 (216.96090698242): SELECT name FROM jos_deeppockets WHERE id=212

142 (32.901763916016): SELECT name FROM jos_deeppockets WHERE id=212

143 (595.8080291748): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

144 (447.03483581543): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

145 (58.174133300781): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

146 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

147 (!!!!! 9729.8622131348): TRUNCATE TABLE jos_trademed_module

148 (106.0962677002): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733554 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

149 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294733554 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

150 (459.90943908691): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

151 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

152 (84.161758422852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

153 (54.121017456055): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

154 (!!!!! 1302.0038604736): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

155 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

156 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

157 (40.054321289062): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294733554 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294733554 AND type='deeppockets_item' AND published='1' LIMIT 1

158 (39.100646972656): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

159 (32.901763916016): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

160 (41.961669921875): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

161 (445.12748718262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

162 (72.956085205078): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294733554 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294733554 AND published='1' LIMIT 1

163 (74.863433837891): select jos_twitters.link from jos_twitters where cat=10

164 (39.100646972656): select jos_facebook.link from jos_facebook where cat=10

165 (39.815902709961): select jos_google_plus.link from jos_google_plus where cat=10

166 (43.153762817383): select jos_linkedin.link from jos_linkedin where cat=10

167 (344.99168395996): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

168 (!!!!! 1205.9211730957): insert into jos_banners_delta values (14615,'2025-08-23 08:25:06','216.73.216.171','view'),(14202,'2025-08-23 08:25:06','216.73.216.171','view'),(14203,'2025-08-23 08:25:06','216.73.216.171','view')

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