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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Mechanism Identified Behind Systemic Fibrotic Disorder

By MedImaging International staff writers
Posted on 09 Nov 2010

Scientists are now closer to understanding the mechanism behind a novel systemic fibrotic disorder that affects some patients with renal insufficiency who had received imaging contrast agents for magnetic resonance imaging (MRI).

Two of these studies on the disorder were published together in the November 2010 issue of the journal Annals of Rheumatic Diseases. Nephrogenic systemic fibrosis (NSF) is a new disease that was first described in 2000. It manifests as progressive fibrosis in feet, legs, thighs, hands, and forearms. Though initially thought to affect only the skin, it has been shown that NSF can also affect internal organs, including the liver, lungs, muscles, heart, thyroid, and dura mater. The disease appears to affect patients with renal failure who receive specific gadolinium-based imaging agents for MRI.

In the first study, the researchers from the Jefferson Institute of Molecular Medicine of Thomas Jefferson University (Philadelphia, PA, USA) performed cell cultures on fibroblasts obtained from affected skin taken from patients with NSF. They discovered that the fibroblasts from these tissues were continually activated, and expressed an increased amount of collagen and other fibrotic proteins, according to Sergio A. Jimenez, M.D., professor of dermatology and cutaneous biology at Jefferson Medical College of Thomas Jefferson University, and codirector of the Jefferson Institute of Molecular Medicine.

"We also found that the fibroblasts express large amounts of another protein called smooth muscle actin, which indicates that they have transformed to myofibroblasts, which are cells that are a step between fibroblasts and smooth muscle cells,” said Dr. Jimenez, who is also director of the division of connective tissue diseases and director of the Scleroderma Center at Jefferson. "Smooth muscle actin is a protein that is normally present in smooth muscle cells. But these are not muscle cells, they are fibroblasts. Somehow the fibroblasts have changed their features to become an aggressive smooth muscle-like cell that produces large amounts of collagen.”

A significant observation was that the activated features of the fibroblasts were maintained in culture for several generations, indicating that the change in the features of these cells was long lasting, and was probably imprinted in their genetic material.

In a second experiment, Dr. Jimenez and colleagues treated normal fibroblasts with several compounds containing gadolinium, the most typically used imaging agent used for MRI. They found that these agents induced exaggerated production of collagen in the normal fibroblasts. "Normal people excrete gadolinium-containing contrast agents rapidly, but the chemical can stay in the body for prolonged periods of time in people with renal disease,” Dr. Jimenez said.

In the second study, the researchers examined the effects of gadolinium on gene expression of macrophages (white blood cells), production of proinflammatory chemicals called chemokines, and activation of a protein complex (NF [nuclear factor]-kappaB) that regulates immune response. They found that gadolinium-contrast agents caused a profound change in activation of these chemicals and proteins, concluding that these alterations may play a crucial role in development of NSF.

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63 (277.04238891602): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (41.961669921875): select jos_twitters.link from jos_twitters where cat=10

65 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

66 (30.040740966797): select jos_google_plus.link from jos_google_plus where cat=10

67 (28.133392333984): select jos_linkedin.link from jos_linkedin where cat=10

68 (44.107437133789): SELECT fid FROM jos_deeppockets WHERE id=294731968 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294731968 AND published='1' LIMIT 1

69 (30.994415283203): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (236.98806762695): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731968 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (236.03439331055): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731968 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (39.815902709961): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (73.909759521484): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (85.830688476562): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (54.121017456055): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (67.949295043945): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (41.961669921875): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (52.928924560547): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (45.061111450195): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (43.869018554688): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (79.154968261719): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731968 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (47.922134399414): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731968 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (55.074691772461): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (62.942504882812): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (86.069107055664): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

105 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

106 (67.949295043945): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731968 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (50.067901611328): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731968 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (97.036361694336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

109 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

110 (53.882598876953): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731968 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (466.10832214355): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731968 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (660.18104553223): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (497.81799316406): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (118.01719665527): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

115 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

116 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

117 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

118 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

119 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

120 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

121 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

122 (213.8614654541): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 21574.974060059): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (798.94065856934): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731968 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731968 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 7848.0243682861): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (106.0962677002): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (218.15299987793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (55.074691772461): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (171.89979553223): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (62.942504882812): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (154.97207641602): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (55.074691772461): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (176.19132995605): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (64.13459777832): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (433.92181396484): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (329.97131347656): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (190.01960754395): SELECT name FROM jos_deeppockets WHERE id=212

138 (39.100646972656): SELECT name FROM jos_deeppockets WHERE id=212

139 (801.08642578125): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (682.83081054688): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (114.91775512695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

142 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

143 (!!!!! 12294.054031372): TRUNCATE TABLE jos_trademed_module

144 (139.95170593262): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731968 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (64.13459777832): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731968 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (936.98501586914): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

149 (54.836273193359): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

150 (!!!!! 1572.1321105957): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (78.916549682617): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

152 (227.92816162109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

153 (74.863433837891): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731968 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731968 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (52.928924560547): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (43.153762817383): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (46.968460083008): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (111.10305786133): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

158 (66.995620727539): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731968 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731968 AND published='1' LIMIT 1

159 (170.94612121582): select jos_twitters.link from jos_twitters where cat=10

160 (50.783157348633): select jos_facebook.link from jos_facebook where cat=10

161 (44.107437133789): select jos_google_plus.link from jos_google_plus where cat=10

162 (44.107437133789): select jos_linkedin.link from jos_linkedin where cat=10

163 (731.9450378418): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1478.910446167): insert into jos_banners_delta values (14615,'2025-06-27 21:41:08','216.73.216.249','view'),(14202,'2025-06-27 21:41:08','216.73.216.249','view'),(14203,'2025-06-27 21:41:08','216.73.216.249','view')

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