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Innovative Techniques Devised for Characterizing Proteins

By MedImaging International staff writers
Posted on 28 Oct 2010

Utilizing a combination of high-powered computers and sophisticated research magnetic resonance (MR) data, a U.S. biophysical chemist has developed techniques that enhance the manner in which scientists can examine and predict the structure and dynamics of proteins found in the human body. These developments could eventually shorten the time it takes researchers to develop new, more effective drugs and better understand biomedical processes that underlie a host of health disorders.

The new techniques "allow us to more accurately understand protein behavior and function at all levels, how enzymes work, and how to develop drugs that bind to certain proteins,” said Dr. Rafael Brüschweiler, a professor in Florida State University's (FSU; Tallahassee, USA) department of chemistry and biochemistry and associate director for biophysics at the U.S. National High Magnetic Field Laboratory at the FSU.

Given that there are hundreds of thousands of different proteins found in the human body, advances such as Dr. Brüschweiler's that can streamline their analysis and understanding are viewed as most desirable in the scientific community.

Over the past several years, Dr. Brüschweiler and his colleagues have incorporated a pair of complementary but powerful tools, both of which provide detailed data about the structure and dynamics of proteins at the atomic level. Nuclear magnetic resonance (NMR) data are first collected for a specific protein that is being analyzed. NMR is a research tool that utilizes high magnetic fields to measure the strengths, directions, and temporary fluctuations of magnetic interactions between the atoms in a protein fragment.

Subsequently, in a technique Dr. Brüschweiler has developed, high-powered computers are used to confirm the NMR data in terms of their realistic representation of protein structure and dynamics, as well as to make additional predictions of those characteristics.

The computational results significantly rely on the shape of the protein's "energy landscape,” the conformational space available to that protein under physiologic conditions. However, due to its intricacy, improving characterizations of the energy landscape is a difficult and time-consuming undertaking. In fact, until recently, a computer simulation of a single protein that represented just a microsecond took several months. Now, with the aid of the powerful computer array at Florida State's High Performance Computing Center, it takes Dr. Brüschweiler and his group only a fraction of the time it once did.

Working with a postdoctoral associate, Da-Wei Li, Brüschweiler has found a highly effective way to use directly the NMR information for improving the protein potential. The basic idea is to "recycle” an existing simulation of an intact protein, using methods taken from statistical physics, for many trial potentials until the one is found that yields the best agreement with experiment. This leads to an increase in speed by a factor of 100,000 or more over previous techniques. The approach is not only efficient but also permits the improvement of the protein potential directly on intact proteins, instead of on small fragments, as was previously the case.

"This has opened up a new way of becoming increasingly quantitative in our computations, which is key in developing a predictive understanding of the functions of proteins,” Dr. Brüschweiler said.

An article describing the research was published online August 16, 2010, in the journal Angewandte Chemie. "This is the culmination of a number of years of research on our part, so obviously we're excited about the progress we have made,” Dr. Brüschweiler said. "While this is fairly basic research designed to develop a greater understanding of life at a molecular level, it opens up a range of possibilities for future advances by scientists all over the world.”

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58 (156.87942504883): SELECT name FROM jos_deeppockets_archive WHERE id=294731792 LIMIT 1

59 (108.00361633301): SELECT a.* FROM jos_components AS a WHERE ( a.admin_menu_link = 'option=com_syndicate' OR a.admin_menu_link = 'option=com_syndicate&hidemainmenu=1' ) AND a.option = 'com_syndicate'

60 (459.90943908691): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731792 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

61 (378.84712219238): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731792 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

62 (!!!!! 2120.0180053711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

63 (109.91096496582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

64 (!!!!! 2142.9061889648): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

65 (133.03756713867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

66 (120.87821960449): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

67 (411.9873046875): SELECT fid FROM jos_deeppockets WHERE id=294731792 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294731792 AND published='1' LIMIT 1

68 (308.99047851562): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

69 (77.962875366211): select jos_twitters.link from jos_twitters where cat=10

70 (37.908554077148): select jos_facebook.link from jos_facebook where cat=10

71 (38.862228393555): select jos_google_plus.link from jos_google_plus where cat=10

72 (36.954879760742): select jos_linkedin.link from jos_linkedin where cat=10

73 (46.014785766602): SELECT fid FROM jos_deeppockets WHERE id=294731792 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294731792 AND published='1' LIMIT 1

74 (42.915344238281): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

75 (233.88862609863): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731792 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

76 (182.8670501709): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731792 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

77 (54.121017456055): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

78 (!!!!! 3709.077835083): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (!!!!! 1410.0074768066): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (82.969665527344): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

88 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

89 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

90 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (79.154968261719): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731792 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

93 (31.948089599609): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731792 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

94 (42.915344238281): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

95 (!!!!! 3242.015838623): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (458.95576477051): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (122.0703125): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

105 (306.12945556641): SELECT show_live FROM jos_com_show_setting LIMIT 1

106 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

107 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

108 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

109 (698.80485534668): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

110 (52.213668823242): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

111 (361.91940307617): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731792 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (379.08554077148): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731792 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

113 (!!!!! 6250.1430511475): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

114 (70.810317993164): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

115 (485.89706420898): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731792 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

116 (366.9261932373): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731792 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

117 (670.19462585449): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731790 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

118 (470.87669372559): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294731790 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

119 (!!!!! 2218.0080413818): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

120 (!!!!! 6137.8479003906): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

121 (351.1905670166): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

122 (65.088272094727): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

123 (447.98851013184): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

124 (204.08630371094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

125 (414.13307189941): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

126 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

127 (377.89344787598): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

128 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

129 (227.92816162109): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

130 (!!!!! 43076.992034912): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

131 (!!!!! 6082.0579528809): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731792 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731792 AND type='deeppockets_item' AND published='1' LIMIT 1

132 (!!!!! 13214.111328125): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

133 (!!!!! 2462.1486663818): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

134 (!!!!! 3639.9364471436): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

135 (46.968460083008): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

136 (!!!!! 1008.9874267578): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

137 (92.029571533203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

138 (247.00164794922): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

139 (89.883804321289): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

140 (708.81843566895): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

141 (341.17698669434): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

142 (!!!!! 2038.9556884766): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

143 (778.9134979248): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

144 (669.00253295898): SELECT name FROM jos_deeppockets WHERE id=212

145 (235.79597473145): SELECT name FROM jos_deeppockets WHERE id=212

146 (671.8635559082): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

147 (748.1575012207): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

148 (607.96737670898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

149 (333.07075500488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

150 (!!!!! 12831.211090088): TRUNCATE TABLE jos_trademed_module

151 (844.00177001953): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731792 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

152 (!!!!! 1167.0589447021): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294731792 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

153 (871.89674377441): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

154 (!!!!! 4418.1346893311): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

155 (497.81799316406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

156 (!!!!! 2013.2064819336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

157 (!!!!! 1543.9987182617): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

158 (!!!!! 1182.0793151855): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

159 (462.05520629883): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

160 (!!!!! 5407.0949554443): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294731792 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294731792 AND type='deeppockets_item' AND published='1' LIMIT 1

161 (998.97384643555): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

162 (324.01084899902): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=0 or channel_id is null)

163 (694.03648376465): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

164 (!!!!! 4238.8439178467): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

165 (696.89750671387): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294731792 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294731792 AND published='1' LIMIT 1

166 (265.83671569824): select jos_twitters.link from jos_twitters where cat=10

167 (146.86584472656): select jos_facebook.link from jos_facebook where cat=10

168 (182.8670501709): select jos_google_plus.link from jos_google_plus where cat=10

169 (134.94491577148): select jos_linkedin.link from jos_linkedin where cat=10

170 (517.12989807129): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

171 (!!!!! 7225.0366210938): insert into jos_banners_delta values (14615,'2025-08-23 11:29:52','216.73.216.171','view'),(14202,'2025-08-23 11:29:52','216.73.216.171','view'),(14203,'2025-08-23 11:29:52','216.73.216.171','view')

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