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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

Nanoparticles Employed As Lethal Beacons to Kill Tumors

By MedImaging International staff writers
Posted on 26 Aug 2010

A group of researchers is developing a way to treat cancer by using lasers to light up nanoparticles and destroy tumors with the ensuing heat.

On July 22, 2010, at the 52nd annual meeting of the American Association of Physicists in Medicine (AAPM) in Philadelphia, PA, USA, investigators from Wake Forest University Baptist Medical Center (Winston-Salem, NC, USA) presented their findings on the latest development for this technology: iron-containing, multiwalled carbon nanotubes (MWCNTs), which are 10,000 times thinner than a human hair. In laboratory experiments, the team revealed that by using a magnetic resonance imaging (MRI) scanner, they could image these particles in living tissue, see as they approached a tumor, and target them with a laser, thereby destroying the tumor.

The research builds on an experimental technique for treating cancer called laser-induced thermal therapy (LITT), which uses energy from lasers to heat and destroy tumors. LITT works by virtue of the fact that certain nanoparticles such as MWCNTs can absorb the energy of a laser and then convert it into heat. If the nanoparticles are zapped while within a tumor, they will heat and kill the cancerous cells.

The problem with LITT, however, is that while a tumor may be distinctly visible in a medical scan, the particles are not. They cannot be tracked once injected, which could put a patient in peril if the nanoparticles were zapped away from the tumor because the aberrant heating could destroy healthy tissue.

Now the Wake Forest Baptist researchers have shown for the first time that it is possible to make the particles visible in the MRI scanner to allow imaging and heating at the same time. By loading the MWCNT particles with iron, they become visible in an MRI scanner. Using tissue containing mouse tumors, they showed that these iron-containing MWCNT particles could destroy the tumors when hit with a laser. "To find the exact location of the nanoparticle in the human body is very important to the treatment,” said Xuanfeng Ding, M.S., who presented the research at the meeting. "It is really exciting to watch the tumor labeled with the nanotubes begin to shrink after the treatment.”

An earlier study by the same group showed that laser-induced thermal therapy using a closely related nanoparticle actually increased the long-term survival of mice with tumors. The next step in this project, according to the investigators, is to see if the iron-loaded nanoparticles can do the same thing. If the work proves successful, it may one day help people with cancer, though the technology would have to prove safe and effective in clinical trials.

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Wake Forest University Baptist Medical Center

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60 (245.09429931641): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

61 (!!!!! 2961.8740081787): select cover from jos_number where journalid in (5) and cover is not null order by left(issue,2)+right(issue,2)*12 desc limit 1

62 (648.02169799805): SELECT fid FROM jos_deeppockets WHERE id=294730869 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294730869 AND published='1' LIMIT 1

63 (142.09747314453): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (763.1778717041): select jos_twitters.link from jos_twitters where cat=10

65 (!!!!! 1481.0562133789): select jos_facebook.link from jos_facebook where cat=10

66 (58.174133300781): select jos_google_plus.link from jos_google_plus where cat=10

67 (29.802322387695): select jos_linkedin.link from jos_linkedin where cat=10

68 (309.94415283203): SELECT fid FROM jos_deeppockets WHERE id=294730869 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294730869 AND published='1' LIMIT 1

69 (196.93374633789): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (895.97702026367): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730869 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (707.86476135254): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730869 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (50.067901611328): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (213.8614654541): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (253.91578674316): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (127.07710266113): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (65.803527832031): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (82.015991210938): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (324.01084899902): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (!!!!! 2450.9429931641): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (44.822692871094): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (26.226043701172): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (25.033950805664): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (36.954879760742): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (59.127807617188): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730869 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (28.133392333984): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730869 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (31.948089599609): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (63.896179199219): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (!!!!! 1551.8665313721): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

105 (101.08947753906): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

106 (72.956085205078): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730869 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (109.91096496582): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730869 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (204.08630371094): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

109 (147.10426330566): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

110 (164.98565673828): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730869 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (579.1187286377): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730869 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (499.96376037598): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (341.89224243164): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

115 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

116 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

117 (37.908554077148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

118 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

119 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

120 (39.100646972656): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

121 (36.954879760742): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

122 (273.9429473877): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 45373.201370239): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (!!!!! 8668.8995361328): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730869 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730869 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (375.98609924316): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (87.976455688477): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (123.97766113281): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (262.97569274902): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (45.061111450195): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (29.087066650391): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (32.901763916016): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (66.041946411133): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (808.9542388916): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (336.88545227051): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (427.9613494873): SELECT name FROM jos_deeppockets WHERE id=212

138 (37.908554077148): SELECT name FROM jos_deeppockets WHERE id=212

139 (584.12551879883): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (500.91743469238): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (859.97581481934): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

142 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

143 (!!!!! 16170.024871826): TRUNCATE TABLE jos_trademed_module

144 (359.05838012695): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730869 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (54.121017456055): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730869 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (938.17710876465): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (335.9317779541): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (333.07075500488): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

149 (69.856643676758): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

150 (!!!!! 1688.0035400391): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (200.98686218262): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

152 (298.02322387695): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

153 (229.1202545166): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730869 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730869 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (34.093856811523): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (120.87821960449): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (195.98007202148): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (329.01763916016): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

158 (195.98007202148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730869 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730869 AND published='1' LIMIT 1

159 (!!!!! 1079.0824890137): select jos_twitters.link from jos_twitters where cat=10

160 (34.809112548828): select jos_facebook.link from jos_facebook where cat=10

161 (32.186508178711): select jos_google_plus.link from jos_google_plus where cat=10

162 (241.04118347168): select jos_linkedin.link from jos_linkedin where cat=10

163 (463.00888061523): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1045.9423065186): insert into jos_banners_delta values (14615,'2025-06-28 02:19:37','216.73.216.249','view'),(14202,'2025-06-28 02:19:37','216.73.216.249','view'),(14203,'2025-06-28 02:19:37','216.73.216.249','view')

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