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Single Functional MRI Scan Could Help Diagnose Bipolar Disorder

By MedImaging International staff writers
Posted on 29 Jul 2010

A single magnetic resonance imaging (MRI) scan may soon help a vast majority of people with bipolar disorder (BPD) to get a faster, more accurate--and possibly life-saving--diagnosis, according to a leading U.S. researcher.

Prof. Mary Phillips, professor of psychiatry and director of the Clinical and Translational Affective Neurosicence Program at the University of Pittsburgh (PA, USA), reported that missed and delayed diagnosis was a major problem with bipolar disorder. She noted, "Only one in five sufferers are correctly diagnosed at first presentation to a doctor and it can take up to 10 years before suffers receive a correct diagnosis.”

A major problem for clinicians is the difficulty of differentiating between unipolar (normal) depression and bipolar disorder. Prof. Phillips explained, "The problem is that sufferers [of bipolar disorder] frequently fail to tell their doctors about hypomanic phases because they can be experienced as quite pleasant or judged not to be abnormal at all.”

However, research performed at Pittsburgh has shown that BPD may soon be more accurately diagnosed with a combination of a functional MRI, which scans the brain's neural pathways, as well as a diffusion tension imaging (DTI), which scans the brain's white matter.

Prof. Philips reported that fMRI scans of the brains of individuals who are suffering depression or bipolar disorder show ‘functionally coupled' activity in two regions of the brain, the amygdala, which processes emotions, and the prefrontal cortex, important for emotional regulation.

Prof. Phillips' study involved MRI scans comparing brain function in two groups of people, one group with bipolar disorder, and the other with depression. It revealed that the two types of depression appear to be easily distinguished "by a very different and distinct pattern of brain activity.” She continued, "If there's a plan to do just one MRI in the future to try to decide whether someone has bipolar or depression, I'd suggest focusing the right prefrontal cortex. If there is any abnormality in functioning between the right and prefrontal cortex and right amygdala, the chances are that the person has bipolar.”

Prof. Phillips suggested that the scans might also be used at some point to predict a future onset of bipolar disorder in young people who are not yet affected by the disease. She reported the study's findings at the Royal College of Psychiatrists' International Congress, held in Edinburgh, Scotland, June 21-24, 2010.

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64 (66.041946411133): select jos_twitters.link from jos_twitters where cat=10

65 (36.954879760742): select jos_facebook.link from jos_facebook where cat=10

66 (36.001205444336): select jos_google_plus.link from jos_google_plus where cat=10

67 (36.001205444336): select jos_linkedin.link from jos_linkedin where cat=10

68 (39.100646972656): SELECT fid FROM jos_deeppockets WHERE id=294730482 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294730482 AND published='1' LIMIT 1

69 (39.100646972656): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (431.06079101562): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730482 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (326.15661621094): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730482 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (54.836273193359): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (62.942504882812): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (27.179718017578): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (45.061111450195): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730482 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730482 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (32.901763916016): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (48.160552978516): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (31.232833862305): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

105 (42.915344238281): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

106 (51.021575927734): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730482 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730482 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (136.13700866699): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

109 (48.87580871582): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

110 (46.014785766602): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730482 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (513.07678222656): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730482 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (517.12989807129): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (309.94415283203): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (76.055526733398): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

115 (44.107437133789): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

116 (46.014785766602): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

117 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

118 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

119 (35.04753112793): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

120 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

121 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

122 (241.04118347168): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 19862.174987793): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (401.97372436523): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730482 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730482 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 7493.9727783203): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (87.02278137207): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (56.982040405273): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (66.041946411133): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (208.85467529297): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (43.869018554688): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (34.093856811523): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (36.001205444336): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (411.03363037109): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (232.21969604492): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (36.954879760742): SELECT name FROM jos_deeppockets WHERE id=212

138 (41.007995605469): SELECT name FROM jos_deeppockets WHERE id=212

139 (773.90670776367): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (515.93780517578): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (64.849853515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

142 (49.114227294922): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

143 (!!!!! 8919.9542999268): TRUNCATE TABLE jos_trademed_module

144 (91.791152954102): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730482 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (52.928924560547): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730482 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (910.99739074707): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (115.15617370605): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

149 (63.896179199219): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

150 (!!!!! 1528.9783477783): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (91.075897216797): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

152 (64.13459777832): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

153 (56.028366088867): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730482 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730482 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (42.915344238281): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (40.054321289062): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (46.968460083008): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (87.02278137207): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

158 (84.161758422852): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730482 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730482 AND published='1' LIMIT 1

159 (51.021575927734): select jos_twitters.link from jos_twitters where cat=10

160 (33.140182495117): select jos_facebook.link from jos_facebook where cat=10

161 (41.961669921875): select jos_google_plus.link from jos_google_plus where cat=10

162 (36.954879760742): select jos_linkedin.link from jos_linkedin where cat=10

163 (272.03559875488): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1083.8508605957): insert into jos_banners_delta values (14615,'2025-06-28 02:12:09','216.73.216.249','view'),(14202,'2025-06-28 02:12:09','216.73.216.249','view'),(14203,'2025-06-28 02:12:09','216.73.216.249','view')

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