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AAPM 2025 - 67th Annual Meeting & Exhibition of the American Association of Physicists in Medicine

PET Imaging Leads to More Individualized Treatment for Non-Hodgkin's Lymphoma

By MedImaging International staff writers
Posted on 19 Jul 2010

According to recent findings, molecular imaging can evaluate and optimize non-Hodgkin's lymphoma therapy with Zevalin (ibritumomab tiuxetan), a front-line radioimmunotherapy pharmacuetical agent that uses a dose of radioactive material and mimics the body's own immune response to target and kill cancer cells while sparing neighboring healthy tissues.

"By using molecular imaging prior to treatment, physicians can improve the targeting of radioimmunotherapy and even allow for a larger and considerably more powerful radiation dose to the cancer without damaging surrounding healthy organs,” said Nafees Rizvi, M.D., department of nuclear medicine and positron emission tomography (PET) research, VU University Medical Center (Amsterdam, The Netherlands). "This allows for an individualized approach to treatments, tailoring therapies to the individual patient.”

Non-Hodgkin's lymphoma, a cancer of the lymphatic system, is considered the fifth-most common cancer in the United States. There are many different forms of lymphoma, and treatment is determined based on disease progression and the kinds of cells affected.

Radioimmunotherapy is a relatively new and highly targeted combination of radiation and immunotherapy that uses molecular imaging to pinpoint the exact location of tumor cells. Once therapy has been mapped, physicians inject antibodies matched with a radioactive compound that targets the antigens of cancer cells, much like how the body's natural immune system works against common viruses and infections. The antibodies bind to the cancer cells, delivering a deadly dose of radiation to the tumor.

This study was conducted to evaluate the effectiveness of a molecular imaging agent called Zr-89-Zevalin, which is used in conjunction with PET, a molecular imaging technique that images biologic mechanisms in the body. Zr-89-Zevalin was assessed as the imaging agent for "scout scans”--initial PET scans used for treatment planning before therapy--for six patients with relapsed B-cell non-Hodgkin's lymphoma scheduled for stem-cell transplant.

Study participants received PET scans after an injection of the imaging agent and again after receiving radioimmunotherapy. The imaging agent provided an accurate portrait of the biodistribution, or the likely path in the body, of a therapeutic dose of Y-90-Zevalin, without any negative impact from simultaneous injection. Results indicate that Zr-89-Zevalin and PET could be more effective than other imaging techniques and could lead to more effective and personalized therapy with Y-90-Zevalin.

Zevalin was developed by Spectrum Pharmaceuticals, Inc. (Irvine, CA, USA).

The study's findings were presented at the Society of Nuclear Medicine's (SNM) 57th annual meeting, June 5, 2010, at Salt Lake City, UT, USA

Related Links:
VU University Medical Center
Spectrum Pharmaceuticals

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63 (72.002410888672): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

64 (79.870223999023): select jos_twitters.link from jos_twitters where cat=10

65 (50.067901611328): select jos_facebook.link from jos_facebook where cat=10

66 (50.067901611328): select jos_google_plus.link from jos_google_plus where cat=10

67 (43.869018554688): select jos_linkedin.link from jos_linkedin where cat=10

68 (87.02278137207): SELECT fid FROM jos_deeppockets WHERE id=294730282 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294730282 AND published='1' LIMIT 1

69 (54.121017456055): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (442.0280456543): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730282 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (345.23010253906): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730282 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (56.028366088867): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (99.18212890625): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (28.848648071289): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (30.040740966797): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (56.028366088867): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730282 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (30.040740966797): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730282 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (34.093856811523): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (72.956085205078): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (40.054321289062): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (37.908554077148): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (31.948089599609): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (32.186508178711): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (33.140182495117): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (92.983245849609): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

105 (56.982040405273): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

106 (65.088272094727): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730282 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (57.93571472168): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730282 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (98.943710327148): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

109 (50.067901611328): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

110 (61.988830566406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730282 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (533.10394287109): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730282 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (559.80682373047): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (416.04042053223): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (90.122222900391): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

115 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

116 (61.03515625): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

117 (38.862228393555): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

118 (113.01040649414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

119 (51.975250244141): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

120 (89.883804321289): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

121 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

122 (539.06440734863): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 21863.93737793): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (463.96255493164): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730282 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730282 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 7874.0119934082): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (100.85105895996): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (72.002410888672): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (70.095062255859): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (220.06034851074): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (35.04753112793): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (30.040740966797): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (377.89344787598): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (270.12825012207): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (36.954879760742): SELECT name FROM jos_deeppockets WHERE id=212

138 (30.040740966797): SELECT name FROM jos_deeppockets WHERE id=212

139 (582.93342590332): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (480.89027404785): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (102.04315185547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

142 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

143 (!!!!! 9017.9443359375): TRUNCATE TABLE jos_trademed_module

144 (113.01040649414): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730282 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (61.988830566406): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730282 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (!!!!! 1067.8768157959): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (77.009201049805): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (82.015991210938): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

149 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

150 (!!!!! 1368.0458068848): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (60.081481933594): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

152 (47.922134399414): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

153 (55.074691772461): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730282 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730282 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (84.877014160156): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (36.001205444336): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (41.007995605469): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (75.101852416992): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

158 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730282 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730282 AND published='1' LIMIT 1

159 (49.114227294922): select jos_twitters.link from jos_twitters where cat=10

160 (41.007995605469): select jos_facebook.link from jos_facebook where cat=10

161 (40.054321289062): select jos_google_plus.link from jos_google_plus where cat=10

162 (32.901763916016): select jos_linkedin.link from jos_linkedin where cat=10

163 (290.87066650391): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1142.0249938965): insert into jos_banners_delta values (14615,'2025-06-28 06:37:11','216.73.216.249','view'),(14202,'2025-06-28 06:37:11','216.73.216.249','view'),(14203,'2025-06-28 06:37:11','216.73.216.249','view')

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