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New MR Techniques Shows Blood Flows Differently through Brains of Schizophrenics

By MedImaging International staff writers
Posted on 28 Jun 2010

Researchers in Germany have used a magnetic resonance imaging (MRI) technique called continuous arterial spin labeling (CASL) to map cerebral blood flow patterns in schizophrenic patients quickly and without using radiation or contrast agents.

The researchers' findings were published in the online edition and July 2010 issue of the journal Radiology. "Arterial spin labeling is a powerful technique that can help reduce the cost and complexity of examinations,” said the study's lead author, Lukas Scheef, M.D., from the department of radiology at the University of Bonn (Germany). "It can also be more readily repeated than methods that involve the use of contrast agents and radiotracers.”

Schizophrenia is a chronic and severe brain disorder that affects approximately 2.4 million American adults, according to the U.S. National Institute of Mental Health (Bethesda, MD, USA). Symptoms can include hallucinations, delusions, disordered thinking, movement disorders, social withdrawal, and cognitive deficits.

In the study, conducted at the University Hospital of Bonn, researchers utilized CASL MRI to compare cerebral blood flow in 11 nonmedicated patients with schizophrenia and 25 healthy controls. The patient group included three women with a mean age of 36 years and eight men with a mean age of 32 years. The control group included 13 women (mean age, 29 years) and 12 men (mean age, 30 years).

The study's findings revealed that compared to the healthy controls, the schizophrenic patients had extensive areas of hypoperfusion, or lower blood flow than normal in the frontal lobes and frontal cortex, anterior and medial cingulate gyri, and parietal lobes. These regions are associated with a number of higher cognitive functions including planning, decision-making, judgment, and impulse control.

Hyperperfusion, or increased blood flow, was observed in the cerebellum, brainstem, and thalamus of the schizophrenic patients. "Our CASL study revealed patterns of hypo- and hyper-perfusion similar to the perfusion patterns observed in positron emission tomography [PET] and single photon emission computed tomography [SPECT] studies of schizophrenic patients,” Dr. Scheef said.

Unlike PET and SPECT scanning, CASL MR images can be rapidly acquired without the use of ionizing radiation or contrast agents. In CASL MRI, arterial blood water is magnetically labeled in order to measure cerebral blood flow noninvasively. "CASL MRI may allow researchers to gain a better understanding of schizophrenia,” Dr. Scheef concluded. "In the long run, it may help to individualize and optimize treatment.”

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65 (29.087066650391): select jos_facebook.link from jos_facebook where cat=10

66 (29.802322387695): select jos_google_plus.link from jos_google_plus where cat=10

67 (28.848648071289): select jos_linkedin.link from jos_linkedin where cat=10

68 (30.994415283203): SELECT fid FROM jos_deeppockets WHERE id=294730001 AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE id=294730001 AND published='1' LIMIT 1

69 (44.107437133789): SELECT id,name,sponsor_text FROM jos_deeppockets dp left outer join jos_channel_sponsor cs on dp.id=cs.fid WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id=212 ORDER BY `ordering`

70 (297.06954956055): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730001 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

71 (272.03559875488): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730001 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

72 (48.87580871582): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

73 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

74 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

75 (39.100646972656): SELECT show_live FROM jos_com_show_setting LIMIT 1

76 (30.994415283203): SELECT show_live FROM jos_com_show_setting LIMIT 1

77 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

78 (27.894973754883): SELECT show_live FROM jos_com_show_setting LIMIT 1

79 (28.133392333984): SELECT show_live FROM jos_com_show_setting LIMIT 1

80 (29.087066650391): SELECT show_live FROM jos_com_show_setting LIMIT 1

81 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

82 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

83 (26.941299438477): SELECT show_live FROM jos_com_show_setting LIMIT 1

84 (32.901763916016): SELECT show_live FROM jos_com_show_setting LIMIT 1

85 (42.915344238281): SELECT show_live FROM jos_com_show_setting LIMIT 1

86 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

87 (66.995620727539): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730001 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

88 (31.948089599609): SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730001 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

89 (31.948089599609): SELECT id,name,title FROM jos_deeppockets WHERE cat=10 AND TYPE='file_folder' AND published=1 AND id != 294743300 AND id != 294743301 AND id != 294743302 AND id != 294743303 AND id != 294743304 AND id != 294743305 AND id != 294743306 AND id != 294743307 AND id != 294743308 AND id != 294743309 AND id != 294743310 AND metakey != 'aacc' ORDER BY `ordering`

90 (68.902969360352): SELECT show_live FROM jos_com_show_setting LIMIT 1

91 (38.862228393555): SELECT show_live FROM jos_com_show_setting LIMIT 1

92 (37.193298339844): SELECT show_live FROM jos_com_show_setting LIMIT 1

93 (34.093856811523): SELECT show_live FROM jos_com_show_setting LIMIT 1

94 (46.014785766602): SELECT show_live FROM jos_com_show_setting LIMIT 1

95 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

96 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

97 (34.809112548828): SELECT show_live FROM jos_com_show_setting LIMIT 1

98 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

99 (33.855438232422): SELECT show_live FROM jos_com_show_setting LIMIT 1

100 (41.007995605469): SELECT show_live FROM jos_com_show_setting LIMIT 1

101 (35.04753112793): SELECT show_live FROM jos_com_show_setting LIMIT 1

102 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

103 (36.001205444336): SELECT show_live FROM jos_com_show_setting LIMIT 1

104 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

105 (71.048736572266): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

106 (68.187713623047): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730001 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

107 (62.942504882812): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730001 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

108 (67.949295043945): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

109 (43.153762817383): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

110 (43.869018554688): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730001 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

111 (522.85194396973): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.id=294730001 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

112 (638.96179199219): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

113 (486.13548278809): SELECT dp.name, dp.id, dp2.name as channel, ex.name as author_name, ex.specialization, ex.images FROM jos_deeppockets as dp LEFT JOIN jos_experts as ex ON ex.id = dp.author LEFT JOIN jos_deeppockets as dp2 ON dp2.id = dp.fid WHERE dp.author != 0 AND dp.cat = 10 AND dp.published = 1 AND ( (dp.fid = 294743300) OR (dp.fid = 294743301) OR (dp.fid = 294743302) OR (dp.fid = 294743303) OR (dp.fid = 294743304) OR (dp.fid = 294743305) OR (dp.fid = 294743306) OR (dp.fid = 294743307) OR (dp.fid = 294743308) OR (dp.fid = 294743309) OR (dp.fid = 294743310) ) ORDER BY RAND() LIMIT 1

114 (82.969665527344): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

115 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

116 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

117 (43.869018554688): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

118 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

119 (360.01205444336): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

120 (41.961669921875): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

121 (37.193298339844): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

122 (292.06275939941): SELECT * FROM trending_articles WHERE `journal_id` = 10 AND `timestamp` <= NOW() + INTERVAL 7 DAY ORDER BY `order`

123 (!!!!! 21390.914916992): SELECT * FROM jos_deeppockets WHERE jos_deeppockets.cat = 10 AND jos_deeppockets.type = 'deeppockets_item' AND jos_deeppockets.published = 1 AND jos_deeppockets.created + INTERVAL 14 DAY >= NOW() ORDER BY jos_deeppockets.hits DESC LIMIT 7

124 (524.04403686523): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730001 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730001 AND type='deeppockets_item' AND published='1' LIMIT 1

125 (!!!!! 7338.0470275879): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

126 (108.00361633301): ( SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.video != '' AND dp.video_source != '' AND dp.cat = 10 AND dp.published = 1 AND dp.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) UNION ( SELECT dpa.id, dpa.name, dpa.title, dpa.video, dpa.video_source, dpa.created FROM jos_deeppockets_archive AS dpa WHERE dpa.video != '' AND dpa.video_source != '' AND dpa.cat = 10 AND dpa.published = 1 AND dpa.type != 'deeppockets_item_link' ORDER BY created DESC LIMIT 3 ) ORDER BY created DESC LIMIT 3

127 (40.054321289062): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

128 (30.994415283203): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803337 LIMIT 1

129 (65.803527832031): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

130 (39.815902709961): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294803276 LIMIT 1

131 (306.84471130371): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

132 (37.908554077148): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets_archive AS dp WHERE dp.id = 294803276 LIMIT 1

133 (32.186508178711): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

134 (28.133392333984): SELECT dp.id, dp.name, dp.title, dp.video, dp.video_source, dp.created FROM jos_deeppockets AS dp WHERE dp.id = 294802958 LIMIT 1

135 (528.09715270996): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

136 (343.08433532715): SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

137 (221.96769714355): SELECT name FROM jos_deeppockets WHERE id=212

138 (33.140182495117): SELECT name FROM jos_deeppockets WHERE id=212

139 (591.99333190918): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

140 (609.15946960449): SELECT *, DATE_FORMAT(publish_up,'%d %b %Y') AS date_publish_up, DATE_FORMAT(publish_down,'%d %b %Y') AS date_publish_down FROM jos_events WHERE state=1 AND publish_up > NOW() and extra_info REGEXP '((;)|(^))212((;)|($))' AND catid IN (0,110) ORDER BY publish_up ASC LIMIT 3

141 (95.129013061523): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

142 (52.928924560547): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

143 (!!!!! 10119.915008545): TRUNCATE TABLE jos_trademed_module

144 (121.11663818359): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730001 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

145 (69.856643676758): SELECT dp.*, ch.title as channel, exp.name as author_name, exp.specialization as author_specialization, exp.images as author_photo FROM jos_deeppockets_archive as dp LEFT JOIN jos_experts as exp ON exp.id = dp.author LEFT JOIN jos_deeppockets as ch ON dp.fid = ch.id WHERE 1=1 AND dp.cat=10 AND dp.id=294730001 AND (dp.type='deeppockets_item' OR dp.type='deeppockets_item_link') AND dp.published='1' LIMIT 1

146 (852.10800170898): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

147 (55.074691772461): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND (type='deeppockets_item' OR type='deeppockets_item_link') AND published='1' LIMIT 1

148 (70.095062255859): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

149 (46.968460083008): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

150 (!!!!! 1292.9439544678): SELECT jos_item.* FROM jos_item INNER JOIN jos_number ON jos_item.numberID=jos_number.id WHERE 1=1 AND (jos_item.imgMini<>'') AND jos_item.type='L' AND jos_item.numberID= ( SELECT jos_number.id FROM jos_number WHERE jos_number.journalID IN (10) and jos_number.id in (select distinct jos_number.id from jos_number join jos_item on jos_item.numberid=jos_number.id where jos_item.type='P') ORDER BY (CONVERT(SUBSTRING(issue,1,2),SIGNED) + (CONVERT(SUBSTRING(issue,3,2),SIGNED)*100)) DESC LIMIT 0,1 ) ORDER BY RAND() DESC LIMIT 6

151 (93.221664428711): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

152 (56.028366088867): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

153 (50.067901611328): SELECT fid FROM jos_deeppockets WHERE cat=10 AND id=294730001 AND type='deeppockets_item' AND published='1' union SELECT fid FROM jos_deeppockets_archive WHERE cat=10 AND id=294730001 AND type='deeppockets_item' AND published='1' LIMIT 1

154 (39.100646972656): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

155 (31.948089599609): select distinct links.* from jos_textlinks links join jos_textlinks_placement placement on links.id=placement.link_id where journal_id=(10) and (channel_id=212 or channel_id is null)

156 (34.093856811523): SELECT livesite FROM jos_dp_categories WHERE id=10 AND published='1' LIMIT 1

157 (61.988830566406): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

158 (45.061111450195): SELECT * FROM jos_deeppockets WHERE 1=1 AND id=294730001 AND published='1' union SELECT * FROM jos_deeppockets_archive WHERE 1=1 AND id=294730001 AND published='1' LIMIT 1

159 (41.961669921875): select jos_twitters.link from jos_twitters where cat=10

160 (31.948089599609): select jos_facebook.link from jos_facebook where cat=10

161 (31.948089599609): select jos_google_plus.link from jos_google_plus where cat=10

162 (32.901763916016): select jos_linkedin.link from jos_linkedin where cat=10

163 (322.10350036621): update jos_bannersmanager_banner set impmade=impmade+1 where id in(14615,14202,14203)

164 (!!!!! 1064.0621185303): insert into jos_banners_delta values (14615,'2025-06-28 04:41:46','216.73.216.249','view'),(14202,'2025-06-28 04:41:46','216.73.216.249','view'),(14203,'2025-06-28 04:41:46','216.73.216.249','view')

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